DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kug and Gm281

DIOPT Version :9

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001380458.1 Gene:Gm281 / 238939 MGIID:2685127 Length:818 Species:Mus musculus


Alignment Length:786 Identity:183/786 - (23%)
Similarity:325/786 - (41%) Gaps:152/786 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   846 NITVYDLGNPTKSTSKMLPITILDVNDNRPVI-----QKTLAT-FRLTESARIGTVVHCLHATDA 904
            ::|:|...|...:.|:.:.:.|.|||: .||.     ||...| ..:||....||:::...|.|.
Mouse    98 SLTIYAKDNHGATASQTIFVQIEDVNE-PPVFIGSLTQKNQVTEIYITEDTAYGTIIYRAAAEDP 161

  Fly   905 DSGINAQVTYALSVECSDFTVNATTGCLRLNKPLDREK-QDNYALHITAKDGGSPVLSSEALVYV 968
            :..:   :.|::|.|.|.||:: :||.:...:.||.|. ..:::|.|...|.|....:....:::
Mouse   162 EGAV---LEYSISPESSGFTID-STGAISTARDLDFESGMRSFSLIIKVVDPGGLFATGNLKIFL 222

  Fly   969 LVDDVNDNAPV-----FGVQEYIFKVR---------------EDLPRGTVLAVIEAVDED-IGPN 1012
            :  :||:..|:     |.::..:.:|.               |::|.|.::|:.:|.||| :|  
Mouse   223 V--NVNNKDPILACSLFNIENGVLRVTFTNSTLHRKVNITLDEEIPVGKMIAMCQATDEDNLG-- 283

  Fly  1013 AEIQFSLKEETQDEELFRIDKHTGAIRTQGYLDYENKQVHNLI---VSAIDGGDPSLTSDMSIVI 1074
             .:.|.|  :|.| :.|.:||..|.:.|..:||.|.....:.:   :.|.| ||...|. :.:..
Mouse   284 -GLTFGL--DTVD-DYFAVDKEKGTVVTTNHLDVEKTGFASALSFSIKACD-GDQRCTV-IPVAT 342

  Fly  1075 MIIDVNENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKITYSITGGD-GLGIFA 1138
            .|..:|:|  :|..|.::.....||...|.|.|..::..|:|...  ..|.|:.:.|. |.|   
Mouse   343 YIRGINDN--SPFCDQYLIRYIGKEEIAKDTVVAKLSCHDLDKPP--DTIHYAPSSGPVGSG--- 400

  Fly  1139 VNDQGSITSLSQLDAETKNFYWLT--LCAQDCAIVPLSNCVE------------------VYIQV 1183
                    .|.:...:||||..:|  |..::..:|...:..|                  :.:::
Mouse   401 --------QLFEQVPDTKNFIQVTKDLDYENPEVVAAGHMYEMMISVFDDLHPSHTVTVTILVEI 457

  Fly  1184 ENENDNIPLTDKPVYYVNVTEASVENVEIITLKAFDPDIDPTQTITYNIVSGN--LVGYFEIDSK 1246
            ..|||..|......|..:|.|.|....::..:.|.|.| .|...:||.|:.|:  .|..|.|...
Mouse   458 APENDFSPKFQALHYVFSVPETSEAFYKVGQVTAIDED-HPPDCLTYKIIKGHSQAVQMFWIHPF 521

  Fly  1247 TGVIK-TTERKLDRENQAEHILEVAISDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVYKVQVPS 1310
            :|||: ||:...:...|....:|....|...| .::.:.:.|.:.|.||.:|.....:|...:|.
Mouse   522 SGVIELTTQPDYESVRQYNLTVEAVDCDRDHP-RTAVATVTVDIEDENDEAPVCTPYLYTAIIPD 585

  Fly  1311 S--ATVNQSIFQVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRG------------HIHIAKP 1361
            :  |..|.:..:::..|.|| ::..:.:.:.||.....|::|..||            |......
Mouse   586 NVIAGTNVNGLKLNCHDRDS-QDFEMRFEMASGNENLHFQLDPTRGSNTPKLVVKNPFHFESGTE 649

  Fly  1362 LDSDNEFEIHIKAEDN-----GIPKKSQTARVNIVVV----PVNPNS--QNAPLIVRKTSENVVD 1415
            |.......:|: .:||     .:..|:.||.::|.|:    |:.|.|  |...|.:..|:.|...
Mouse   650 LQLQYHLVVHV-IDDNLQYGKAVKSKTGTAVIDINVMRTSTPIPPTSSEQRKGLTIVYTAINTYK 713

  Fly  1416 LTENDKPGFLVTQILAVDDDNDQLWYNISNGNDDNTFYIGQDNGN-ILLSKYLDYETQQSYNLTI 1479
            .::...| |:.| ::||                   |::|..:.. .||.:|.:.:| :|..:|.
Mouse   714 SSDWYVP-FIFT-LMAV-------------------FFVGLVSWMCFLLWRYGNIKT-KSQRMTK 756

  Fly  1480 SVTDGTFTAFTNLLVQVIDINDNPPQFAKDVYHVNISENIE---EESV---IMQLHATDRDEDKK 1538
            .|:...|.....:      :.|. .|..|:|.....::|:|   |.:|   :....||  |....
Mouse   757 EVSKSKFKGMKYV------VGDR-SQREKNVITETRNKNLEVLTETTVYETVFDGEAT--DPGMM 812

  Fly  1539 LFYHLH 1544
            ..|||:
Mouse   813 FLYHLN 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
E_set 309..390 CDD:298831
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637 8/26 (31%)
Cadherin_repeat 883..976 CDD:206637 24/94 (26%)
Cadherin_repeat 984..1082 CDD:206637 29/116 (25%)
Cadherin_repeat 1092..1189 CDD:206637 23/117 (20%)
Cadherin_repeat 1197..1295 CDD:206637 27/100 (27%)
Cadherin_repeat 1303..1386 CDD:206637 19/101 (19%)
Cadherin_repeat 1413..1502 CDD:206637 15/89 (17%)
Cadherin_repeat 1510..1608 CDD:206637 11/41 (27%)
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637
Cadherin_repeat 2774..2856 CDD:206637
Cadherin_repeat 2865..2963 CDD:206637
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:280389
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
Gm281NP_001380458.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845967
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.