DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kug and cdh-7

DIOPT Version :9

Sequence 1:	NP_001027138.2	Gene:	kug / 40191	FlyBaseID:	FBgn0261574	Length:	4699	Species:	Drosophila melanogaster
Sequence 2:	NP_497075.2	Gene:	cdh-7 / 175143	WormBaseID:	WBGene00000399	Length:	1364	Species:	Caenorhabditis elegans

Alignment Length:	1385	Identity:	286/1385 - (20%)
Similarity:	515/1385 - (37%)	Gaps:	361/1385 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2537 LKISLLPENVYSPLFDQSTYEAQVPENLLHGHNII---TVKASDGDFGTYANLYYE--------- 2589
            |.:.|||..||..|....:...::|.|...|..||   .::||: |.....||..|
Worm     7 LLLLLLPLLVYGDLLSIPSTTFKIPRNAQEGDLIIGPEFIRASE-DIDEALNLELEGTNPSPIAI 70

  Fly  2590 ----IVSEEMKKIFLID-------------QTTGVITSKV-----TFDREKKDEYVVLLKVSDGG 2632
                |.:.:..|..|::             |..|||:.||     .|:.|...:...:.::|:..
Worm    71 NGSIIDAGQPVKFILVNKNAFDSGKSKVKLQAIGVISGKVQEETINFEVEASSDLPSIPEISNFV 135

  Fly  2633 GKFGFASLKVIVVDVNDNVP----YFLLKEYKMVVSTTVEANQTIL-TVKAKDDD---------- 2682
            .|..|...:..:|.|:..:|    ..:|..|...|:.|.|.::.|| ||....|.
Worm   136 VKSDFQEKETAIVRVSSPIPPNSELDILGSYAQRVTATFEDDKIILNTVPCHADTPCEVTFPFVV 200

  Fly  2683 --IVDNGSVH------FQIVQKSNDKAVKDVIE--INEKTGDIVFKSKAESYGVNSYQFFVRASD 2737
              ::.||..|      ||..:||:.|..:.:.:  |.|.||:.....|..:.|.:|...:.....
Worm   201 ILVLRNGENHVEALLTFQEEKKSSLKMAQKLYQTTIEEHTGEQDHLVKISTKGGSSEVLYSLRDA 265

  Fly  2738 RG--------------EPQFHS----EVPVSIEIIETDAN-----------IPTFEKSSVLLKII 2773
            .|              .|:|.|    ...|::.::.||.:           :|..|| :|:....
Worm   266 SGLFSIHPKEGILSILHPEFLSISSFGDTVNLTVVATDGDKTADAMINVKIVPEVEK-NVVFGFE 329

  Fly  2774 ESTPPGTVLTKLHMIGNYTFK------FSIAADQ-DHFMISDSGELILQQTLDREQQESHNLIVV 2831
            :.:...|......::||...|      :.|...: |.:.:..:|:|:....:.:..:|....:||
Worm   330 KESYDITAENINSILGNIKAKSASPVVYRITEGRIDLYKVEPNGDLVYTGKMVKGDREDDVTVVV 394

  Fly  2832 AETSTVPVFFAYADVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNG--- 2893
            .:..   :..|...|.|:::....|         ..|.::..||:   ..:|:.|    |||
Worm   395 QQGG---LKMASTKVHINLKGIGSN---------PVSTSDELEKI---ELISSED----PNGVVV 440

  Fly  2894 ----------DIRYYLESDTENIQNIFDIDIYSGWITLLTSLDREVQSEYN-------------- 2934
                      |.:...|...||     .:|.....|.|...| .|::||..
Worm   441 TLIQFQDEDKDAKLTYELTMEN-----GVDENGNMIPLQEQL-FEIKSEEKVAHLVVSGNLKTSK 499

  Fly  2935 -----FKVIAADNGHPKHDAKVPVTIKIV---DYNDNAP----VFKLPIEGLSVFENALPGTVLI 2987
                 .|:.|.|:.||| :..|.||..||   :.::..|    :..||.|.|...::|: |:.:.
Worm   500 ITTILLKITARDSTHPK-EPSVTVTRLIVIQREKSEEEPMGLNLIPLPTEILVPVDSAV-GSFIY 562

  Fly  2988 NLLLIDPDIEKQEMDFFIVSGDKQAQFQIGKSGELFIAKPL--DREQLMFYNLSIIATDGKFTAK 3050
            .:.::.   .|:.:.:.|   :.:..|||...|.:...|.|  :.|||   .:.:..:||  :.|
Worm   563 KVTVLP---MKENLQYSI---EPEHLFQILDDGSIVTQKELTVEAEQL---KIHVEVSDG--SEK 616

  Fly  3051 ANVEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFDFQSKLRFYL-SGKGADDFSI 3114
            .:.|..:.......|:..:.||.::........:.:..|.|:..:.:...:|.| .|..:..|.|
Worm   617 KSTETTLTLKKTLHPHFTESRYDVTLPRQTPKDSVITVVSAVGGNGEPVNQFVLKKGGHSKHFKI 681

  Fly  3115 GKESGILKVASALDR--------------ETTPKYKLVAHVQDGK------DFTQECFSEIIITV 3159
             .|.|.|::|...:|              ...|...:..|:...|      |..:   ::|..||
Worm   682 -DEKGALRLADEQERFDDLDDEMDLLVALAENPTISVPVHISLKKNRNPRIDLVE---NQIFATV 742

  Fly  3160 NDINDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGENHDYFKISKSTGI 3224
               .||:||                |:.:.||....|:.     :|:.:..:
Worm   743 ---YDNLPI----------------NSYVGKVEVASKEL-----VKFEMTSD------------- 770

  Fly  3225 IRLHKSLDRETISLFNL----TVKAED--CGVPKLHSI----------------ATVAVNILDIN 3267
                   ::...|||.:    |::::|  .|...:|..                |||.::::..|
Worm   771 -------EKGMSSLFGIEEDGTIRSKDWLAGSEGMHKFSVLASNIDQAGVRSANATVVIDVIKSN 828

  Fly  3268 DNPPEFSMRQ----YSCKILENATHGTEVCKVYATSID---------IGVNADIHYFIMSGNEQG 3319
            :..|:|...:    |   :.||....|.:.||.|..:.         ||.|::|
Worm   829 ECSPKFKRDENLIFY---VRENTPIDTVIGKVSADVLPGKCALEYSIIGPNSEI----------- 879

  Fly  3320 KFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYR 3384
             ..::|..|:|..:...|:|..|.|.||::.:.|....:.:.|  .:.|||::|:...|......
Worm   880 -LSINSANGELKTSKEFDFEKQKSYLLTLKLVAGKYNSVESGA--ELKILDVDDHEVKFELQEQT 941

  Fly  3385 INVNEDIFVGSKILDVKATDEDSDVNGLVTYNIERGDNIGQFSIDPKNGTISVSRPLDRETISHY 3449
            :.:.||..:.:.:..||||:.|....  |.|:::.| :..|||::.|.|.:.|.:.||||.:.::
Worm   942 VEIPEDAPLNTVVATVKATEGDESQE--VFYHLKAG-SPPQFSLNSKTGEVMVEQALDREALDNF 1003

  Fly  3450 TLEIQACDQGDPQRCNSVPININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKISDADETP 3514
            .:||.|.:..|.....::.:.:.:.|.|||.|.|....|..|:.::.::|...|.....|.|.:.
Worm  1004 EIEIGASNSVDLIGTAAMKLLVKVKDVNDNGPTFDRPQYFTVVSKDTVVGAELLELNAYDPDLSD 1068

  Fly  3515 NTTPYTFDIRSGNEGGLFRLEQDGSLRTASRFNH-----NLQDEFVIQVRVFDNGTPPLYSDAWV 3574
            ......:.:                  |||.|.:     |::|  |:.:|..:|  |.:|....:
Worm  1069 QEKKLEYTV------------------TASSFEYRGMSRNVED--VLDIRGGEN--PKIYLSKPL 1111

  Fly  3575 VVKIIEESQYPPIVTPLEVTINSFEDDFSGAFIGKVHASDQDKYDELNFSLVSGPDDMYQ---SS 3636
                   :.|...|..:::.:....|...|....:|:..|..  |.|:..|...|..:.|   ..
Worm  1112 -------TDYVGGVFNVQLQVRDTVDGTIGKSALRVYVHDSS--DLLSLELPYSPSTVSQGVIQE 1167

  Fly  3637 KLFNISNNTG--------------KIYAISNLDIGLYKLNVSVSDGKFHVFSIVKINVELVTNDM 3687
            ...|:||:||              .|.:.:::|:.:...|.|:|:       ||.....|...||
Worm  1168 FTENLSNSTGLTAIPKSVYYKAPHGIMSTNSIDLQVIFFNKSMSE-------IVPAERILAMQDM 1225

  Fly  3688 LKESVVIRFRRISASEFLLS 3707
            .::......|: .||.:|::
Worm  1226 RQDKHQPILRK-PASPYLMT 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kug	NP_001027138.2	Cadherin_repeat	66..178	CDD:206637
		Cadherin_repeat	187..285	CDD:206637
		E_set	309..390	CDD:298831
		Cadherin_repeat	404..503	CDD:206637
		Cadherin_repeat	513..609	CDD:206637
		Cadherin_repeat	622..708	CDD:206637
		Cadherin_repeat	776..873	CDD:206637
		Cadherin_repeat	883..976	CDD:206637
		Cadherin_repeat	984..1082	CDD:206637
		Cadherin_repeat	1092..1189	CDD:206637
		Cadherin_repeat	1197..1295	CDD:206637
		Cadherin_repeat	1303..1386	CDD:206637
		Cadherin_repeat	1413..1502	CDD:206637
		Cadherin_repeat	1510..1608	CDD:206637
		Cadherin_repeat	1621..1713	CDD:206637
		Cadherin_repeat	1724..1811	CDD:206637
		Cadherin_repeat	1819..1927	CDD:206637
		Cadherin_repeat	1948..2030	CDD:206637
		Cadherin_repeat	2037..2136	CDD:206637
		Cadherin_repeat	2144..2235	CDD:206637
		Cadherin_repeat	2246..2336	CDD:206637
		Cadherin_repeat	2345..2445	CDD:206637
		Cadherin_repeat	2453..2545	CDD:206637	4/7 (57%)
		Cadherin_repeat	2555..>2633	CDD:206637	23/111 (21%)
		Cadherin_repeat	2658..2759	CDD:206637	31/139 (22%)
		Cadherin_repeat	2774..2856	CDD:206637	14/88 (16%)
		Cadherin_repeat	2865..2963	CDD:206637	30/132 (23%)
		Cadherin_repeat	2974..3063	CDD:206637	18/90 (20%)
		Cadherin_repeat	3072..3165	CDD:206637	20/113 (18%)
		Cadherin_repeat	3173..3269	CDD:206637	16/117 (14%)
		Cadherin_repeat	3277..3374	CDD:206637	25/109 (23%)
		Cadherin_repeat	3383..3479	CDD:206637	26/95 (27%)
		Cadherin_repeat	3488..3579	CDD:206637	17/95 (18%)
		Cadherin_repeat	3590..3681	CDD:206637	21/107 (20%)
		EGF_CA	3866..3903	CDD:238011
		Laminin_G_2	3953..4077	CDD:280389
		EGF_CA	<4121..4150	CDD:238011
		EGF_CA	4152..4189	CDD:238011
		EGF_CA	4195..4225	CDD:238011
		EGF_CA	4227..4262	CDD:214542
cdh-7	NP_497075.2	Cadherin_repeat	232..319	CDD:206637	14/86 (16%)
		Cadherin_repeat	548..>613	CDD:206637	15/74 (20%)
		Cadherin_repeat	842..931	CDD:206637	25/105 (24%)
		Cadherin_repeat	939..1033	CDD:206637	26/96 (27%)
		Cadherin_repeat	1041..1147	CDD:206637	23/136 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010