DRSC/TRiP Functional Genomics Resources

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Protein Alignment kug and Celsr3

DIOPT Version :10

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:NP_001346501.1 Gene:Celsr3 / 107934 MGIID:1858236 Length:3309 Species:Mus musculus


Alignment Length:1801 Identity:464/1801 - (25%)
Similarity:736/1801 - (40%) Gaps:370/1801 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  2734 RASDRGEPQF-----HSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTF 2793
            ||::| .|||     .:.||      |.:|     ..:|||..:.:...||.....:        
Mouse   308 RAANR-HP
QFPQYNYQTLVP------ENEA-----AGTSVLRVVAQDPDPGEAGRLI-------- 352

  Fly  2794 KFSIAA-----DQDHFMIS-DSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVLIDVRD 2852
             :|:||     ..:.|.|. .||.:.....||||..|.|.|.|.|:....|...|...|.:.|.|
Mouse   353 -YSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVAD 416

  Fly  2853 ENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRY-YLESDTEN--IQNIFDIDI 2914
            .||:.|.|:...|..::.||.|:...::::.|||.|..||.::|| ::.|....  ....|:||.
Mouse   417 RNDH
APVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAVRTAAAAAFEIDP 481

  Fly  2915 YSGWITLLTSLDREVQSEYNFKVIAADNGH---PKHDAKVPVTIKIVDYNDNAPVFKLPIEGLSV 2976
            .||.|:....:|||....|...|.|:|.|.   |: .|.|.|.|.::|.|||||.|........|
Mouse   482 RSGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRVHITVLDENDN
APQFSEKRYVAQV 545

  Fly  2977 FENALPGTVLINLLLIDPDIEKQEM-DFFIVSGDKQAQFQIGK-SGELFIAKPLDREQLMFYNLS 3039
            .|:..|.||::.:...|.|.:...: .:.|:||:.:..|.|.. :||:.:..|||.|....|.|.
Mouse   546 REDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALR 610

  Fly  3040 IIATDGKFTAKAN----VEIDVKDINDNTPYCLKPRYHISTNESISIGTTLVEVKAIDFDF--QS 3098
            |.|.|......:|    ..|.|.||||:.|..:...:.:|..|:..:|.:::.::|:|.|.  .|
Mouse   611 IRAQDAGRPPLSNNTGLASIQVVDINDH
APIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENS 675

  Fly  3099 KLRFYLSGKGAD-DFSIGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFSEIIITVNDI 3162
            :|.:.|:|..:| .|.|...:|.:.|:..||||:...|......:|.........:.:.:||.|:
Mouse   676 RLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV 740

  Fly  3163 NDNMPIFSMAQYRVSVPEDAQLNTLITKVHAMDKDFGVNRQIKYSLMGEN-HDYFKISK--STGI 3224
            |||.|.|:|.:|.:.:.|||.:.|.:..|.|:|:|  .|..|.|.:.|.| .:.|.||.  ..|:
Mouse   741 NDN
RPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVGL 803

  Fly  3225 IRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPPEFSMRQYSCKILENATHG 3289
            :.|...||.:....|.|.:.|.|   ..||....|.:||.|.|.:.|.|....||..:.|:...|
Mouse   804 VTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTH
RPVFQSAHYSVSMNEDRPVG 865

  Fly  3290 TEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMDSTTGDLVLNATLDYEMSKFYFLTIQAIDGG 3354
            :.|..:.|:..|:|.||.|.|.:.....|  |::|:.:|.:.|.|.||||....|.|.|.|.|.|
Mouse   866 STVVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNG 928

  Fly  3355 TPPLSNNAYVNISILDINDNSPTFLQNLYRINVNEDIFVGSKILDVKATDEDSDVNGLVTYNIER 3419
            .|..::..||.:.:.|:|||:|.|:.:.|...|:||....:.:|.:.|||.|:..||.|.|..:.
Mouse   929 IPQKADTTYVEVMVNDVNDN
APQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQN 993

  Fly  3420 G-DNIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQGDPQRCNSVPININILDTNDNAPIF 3483
            | |..|.|:|:|.:|.:...|.||||.:..|.|...|.|:|.|.....|.|.:.:.|.|||||:|
Mouse   994 GEDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVPPLRTPVSIQVTVQDVNDNAPVF 1058

  Fly  3484 SSSNYSVVLQENRLLGYVFLTFKISDADETPNTTPYTFDIRSGNEGGLFRLE-QDGSLRTASRFN 3547
            .:..:.|.::||.::|.|.......|.|:.|| ....:.|..||...||::: ..|.|......:
Mouse  1059 PAEEFEVRVKENSIVGSVVAQITAVDPDDGPN-AHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1122

  Fly  3548 HNLQDEFVIQVRVFDNGTPPLYSDAWVVVKIIEESQYPPIVTPLEVTINSF----EDDFSGAFIG 3608
            :..:.|:||.|:.   .:.||.|.|.|.|::::::...|::...::..|::    .|.|....||
Mouse  1123 YEARQEYVIVVQA---TSAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIG 1184

  Fly  3609 KVHASDQDKYDELNFSLVSGPDDMYQSSKLFNISNNTGKIYAISNLDIG---LYKLNVSVSDGKF 3670
            ::.|.|.|..|.|.:|...|     ...:|..::..:|::.....||..   :..:.|:|:||..
Mouse  1185 RIPAYDPDVSDHLFYSFERG-----NELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTDGLH 1244

  Fly  3671 HVFSIVKINVELVTNDMLKESVVIRFRRISASEF---LLSHRKTFMRSIRNIMRCRQKDVILITL 3732
            .|.:...:.|.::|.::|..|:.:|...:....|   ||.|   |:..:..::....:||.:..:
Mouse  1245 SVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGH---FLEGVAAVLATPTEDVFIFNI 1306

  Fly  3733 QSDYQKASQHAVGNRRARSIDSDLNVVFAVRKQQIIP------DSDEFFTSDEIRQTLIDKKNEI 3791
            |:|..      ||.       :.|||.|:.    :.|      .:..:|:|:|:::.|..::..:
Mouse  1307 QNDTD------VGG-------TVLNVSFSA----LAPRGAGAGAAGPWFSSEELQEQLYVRRAAL 1354

  Fly  3792 ENETNLVVEDVLPSTCQSNKNDCVHGECKQILQ---ILKNNVTTTFTDVISFAAPSYIPVN---- 3849
            ...:.|   ||||    .:.|.|:...|:..::   :|:.:.:..|   ::..:..:.|:.    
Mouse  1355 AARSLL---DVLP----FDDNVCLREPCENYMKCVSVLRFDSSAPF---LASTSTLFRPIQPIAG 1409

  Fly  3850 -TCVCRPGFDGKHCKETVNACSTDPCSPQRICMPSGSALGYQCVCPKGFSGTYCE---------- 3903
             .|.|.|||.|..|:..::.|.::||.....|.....  ||.|||...|:|..||          
Mouse  1410 LRCRCPPGFTGDFCETELDLCYSNPCRNGGACARREG--GYTCVCRPRFTGEDCELDTEAGRCVP 1472

  Fly  3904 ---RKSSKCSNE-------SCDMG--------LFTAVSFGGKSYAHYKINKVKAKFTLENGFSYS 3950
               |....|:|.       .|..|        ...|.||...|:..::..:.:...||      |
Mouse  1473 GVCRNGGTCTNAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTL------S 1531

  Fly  3951 LQIRTVQQTGTLLY---ASGKVDYNILEIINGAVQYRFDLGSGEGVISVS-SINISDGEWHQISL 4011
            |...|||.:|.|.|   .:.|.|:..||::.|.|:..:..|....|:|.: ...:|||:||.:.|
Mouse  1532 LSFATVQPSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHL 1596

  Fly  4012 ERSLNSAKVMVDNKHVSHGSAPGVNGILNIQSNDIFV----GAEVRPH----------------- 4055
             |..|  |...|....:.|.:.....:|::...::.|    |||:..:                 
Mouse  1597 -RYYN--KPRTDALGGAQGPSKDKVAVLSVDDCNVAVALQFGAEIGNYSCAAAGVQTSSKKSLDL 1658

  Fly  4056 --PSIIG--------YEDIQRGFIGCMANIKI--AKESLPLYISGGSTIAALKRFTNVEFKCDPS 4108
              |.::|        :....:.|||||.::.|  .:..:..:::...|:|..:            
Mouse  1659 TGPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRRMDMAAFVANNGTMAGCQ------------ 1711

  Fly  4109 NVLVRLGICGSQPCANSGICKELDTDVFECACQPRYSGKHC------------------------ 4149
               .:...|.|.||.|:|.|.| ....|.|.|...:.||.|                        
Mouse  1712 ---AKSHFCASGPCKNNGFCSE-RWGGFSCDCPVGFGGKDCRLTMAHPYHFQGNGTLSWDFGNDM 1772

  Fly  4150 ----------------------EIDLDPCSSGPCLF----------------------------- 4163
                                  ::.|.|.|...|..                             
Mouse  1773 AVSVPWYLGLSFRTRATKGILMQVQLGPHSVLLCKLDRGLLSVTLNRASGHTVHLLLDQMTVSDG 1837

  Fly  4164 -------------GGRCDYH------------------GPNNYSCTCPIHLSG------------ 4185
                         |||..:|                  |.........:|:.|            
Mouse  1838 RWHDLRLELQEEPGGRRGHHIFMVSLDFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEGHQG 1902

  Fly  4186 -KRCEYGKF-----------------------CT-PNPCKNG-----GICEEGDGISHCMCR-GY 4219
             ..|..|.:                       || .|||.:|     ..|::......|.|| ||
Mouse  1903 LVGCIQGVWIGFTPFGSSALLPPSHRVNVEPGCTVTNPCASGPCPPHADCKDLWQTFSCTCRPGY 1967

  Fly  4220 TGPTCEIDVDECENQPCGNGATCIN---EPGSFRCICPSYLTGASC 4262
            .||.|   ||.|...||.|..:|.:   .|..:.|.|.|...|..|
Mouse  1968 YGPGC---VDACLLNPCQNQGSCRHLQGAPHGYTCDCVSGYFGQHC 2010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637
Cadherin_repeat 2037..2136 CDD:206637
Cadherin_repeat 2144..2235 CDD:206637
Cadherin_repeat 2246..2336 CDD:206637
Cadherin_repeat 2345..2445 CDD:206637
Cadherin_repeat 2453..2545 CDD:206637
Cadherin_repeat 2555..>2633 CDD:206637
Cadherin_repeat 2658..2759 CDD:206637 9/29 (31%)
Cadherin_repeat 2774..2856 CDD:206637 24/87 (28%)
Cadherin_repeat 2865..2963 CDD:206637 34/103 (33%)
Cadherin_repeat 2974..3063 CDD:206637 29/94 (31%)
Cadherin_repeat 3072..3165 CDD:206637 25/95 (26%)
Cadherin_repeat 3173..3269 CDD:206637 32/98 (33%)
Cadherin_repeat 3277..3374 CDD:206637 33/96 (34%)
Cadherin_repeat 3383..3479 CDD:206637 35/96 (36%)
Cadherin_repeat 3488..3579 CDD:206637 26/91 (29%)
Cadherin_repeat 3590..3681 CDD:206637 21/97 (22%)
EGF_CA 3866..3903 CDD:238011 11/36 (31%)
Laminin_G_2 3953..4077 CDD:460494 38/158 (24%)
EGF_CA <4121..4150 CDD:238011 12/74 (16%)
EGF_CA 4152..4189 CDD:238011 11/109 (10%)
EGF_CA 4195..4225 CDD:238011 13/36 (36%)
EGF_CA 4227..4262 CDD:214542 12/37 (32%)
Celsr3NP_001346501.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 148..189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..314 3/6 (50%)
Cadherin_repeat 321..420 CDD:206637 31/118 (26%)
Cadherin_repeat 428..532 CDD:206637 34/104 (33%)
Cadherin_repeat 541..638 CDD:206637 29/96 (30%)
Cadherin_repeat 646..743 CDD:206637 25/96 (26%)
Cadherin_repeat 751..845 CDD:206637 32/98 (33%)
Cadherin_repeat 853..948 CDD:206637 33/96 (34%)
Cadherin_repeat 956..1054 CDD:206637 35/97 (36%)
Cadherin_repeat 1062..1156 CDD:206637 26/97 (27%)
Cadherin_repeat 1176..1257 CDD:206637 21/85 (25%)
EGF_CA 1428..1462 CDD:238011 11/35 (31%)
EGF_CA 1472..1505 CDD:238011 5/32 (16%)
LamG 1508..1691 CDD:238058 46/191 (24%)
EGF_CA 1717..1748 CDD:238011 13/31 (42%)
LamG 1755..1912 CDD:238058 13/156 (8%)
EGF_CA 1939..1973 CDD:238011 13/36 (36%)
EGF_CA 1973..2011 CDD:238011 13/38 (34%)
Laminin_EGF <1994..2033 CDD:395007 6/17 (35%)
EGF_Lam 2030..>2054 CDD:238012
EGF_Lam 2067..>2105 CDD:238012
HormR 2117..2181 CDD:214468
GAIN 2200..2448 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2360..2395
GPS 2474..2527 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2478..2528
7tm_GPCRs 2534..2787 CDD:475119
TM helix 1 2537..2561 CDD:410628
TM helix 2 2570..2591 CDD:410628
TM helix 3 2601..2623 CDD:410628
TM helix 4 2642..2658 CDD:410628
TM helix 5 2677..2700 CDD:410628
TM helix 6 2723..2745 CDD:410628
TM helix 7 2749..2774 CDD:410628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2831..2852
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2887..2927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2977..3000
Atrophin-1 <3089..>3307 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3091..3309
Blue background indicates that the domain is not in the aligned region.

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