DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kug and si:dkey-22o22.2

DIOPT Version :9

Sequence 1:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster
Sequence 2:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio


Alignment Length:2722 Identity:672/2722 - (24%)
Similarity:1111/2722 - (40%) Gaps:544/2722 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly  1968 IVDGNT----NECFQIEKYTGIITTRNFEILNNENDRDYALHVRASDGIFSAILIVKIKVLSAID 2028
            :|.|.|    ::|.: :...|:.|     :|..::..|::|....:.|     .::|.....|.|
Zfish    46 VVAGFTFPLGDKCKE-DNLAGLKT-----VLTGDDSLDFSLEYLGNKG-----FVLKTTETFATD 99

  Fly  2029 SNFAFQRESYRFSAFENNTKVATIGLVNVIGNTLDENVEYRILNPTQLFD--IGISSGALK---- 2087
            |..:: ..|.|.......|:..|:.:     ..|.::.|.|..|.:.:..  ||:.||:.|    
Zfish   100 SKLSY-TVSARLPRCNGTTEEVTVKI-----KMLQKDDETRRFNESSVSTGVIGVKSGSRKPRAV 158

  Fly  2088 ------TTGVIFDREVKDL-------------YRLFVEAKSMLYDGMNSN----VRRAVTSIDIS 2129
                  |..|..|.:|.||             :.:..|..|.:....:|.    ..|.|::.::.
Zfish   159 SEEVSYTVTVSEDVKVGDLIFTVPDQKFEKKWFEVVSEGNSPIQMERDSGRVYLAHRLVSATEVM 223

  Fly  2130 VLDVNDN------CPLFVNM-------------PYYATVSIDDPKGTIIMQVKAIDLDSAENGEV 2175
            |...|..      |.|.:.:             ||.|.|..|...|:::.::.|...|.:. |..
Zfish   224 VKIHNMRGDEWYLCRLTLTLPNMSNLQWAMFPYPYLAAVGPDTGAGSVVYKLVAQSPDGSV-GTA 287

  Fly  2176 RYELKKGNGELFKLDRKSGELSIKQHVEGHNRNYELTVAAYDGAITPCSSEAPLQVKVIDRSMPV 2240
            .:.|..|..:.|::|:.:||:.........::.|.|||.|.|.. ....:.|.|.:....|. |.
Zfish   288 HFLLVDGGEDSFEVDQTTGEVKTTGRPLTPSKEYTLTVQAVDSQ-GRRGTHASLFILAGFRP-PQ 350

  Fly  2241 FEKQFYTVSVKEDVEMYSALSVSIEAESPLGRSLIY-TISSESQSFEIDYNTGSIFVVNELDYEK 2304
            |....||:.:.|...:..|::| ::|.|...::|.| .:.:.|..|.|:..:|::.:...:|||.
Zfish   351 FTNTTYTIHIPESSAVGQAVAV-VQAISFQRKTLSYMLLVNPSNLFSINQESGALSLTRTVDYES 414

  Fly  2305 ISS-HDVSIRATDSLSGV--YAEVVLSVSIMDVNDCYPEIESDIYNL-TIPENASFGTQILKINA 2365
            ... |.:.:||::..:|:  .||||  |.|.|.|||.||....||:. .:||....||.:|::.|
Zfish   415 GQHLHHLQVRASEPDTGLSNMAEVV--VHITDENDCTPEFMHSIYSRDNVPETTPTGTSLLQVLA 477

  Fly  2366 TDNDSGANAKLSYYIESINGQNNSELFYIDVT-DGNLYLKTPLDYEQIK--YHHIVVNVKDHGSP 2427
            .|.|:|.||:|||:|:|::         .|:| .|.:.....||||:..  |...||.| |.|:|
Zfish   478 RDCDTGLNAELSYFIQSVD---------FDITSQGVVSPSQRLDYERPNHMYECTVVAV-DKGTP 532

  Fly  2428 SLSSRSNVFITVKDLNDNAPCFVEPSYFTKVSVAAVRGQFVALPKAYDKDISDTDSLEYKIVYGN 2492
            ..:..:::.|.:.::||.||.|.:..|.|.:|..|.....||:..|.|   .|.|.:.|.|..||
Zfish   533 PRTGTASIRIRMANVNDEAPVFSQTIYKTFLSEDAGPETLVAIVHAKD---PDGDGVTYAITGGN 594

  Fly  2493 ELQTYSIDKLTGVISLQNMLNFTDKS--------STVLNISVSDGVHTAYARLKISLLPE----- 2544
            |...:.:|...|:|.|:       :|        ..|||::.:|. :.|...|.:|...:     
Zfish   595 EDSNFELDNQKGIIKLR-------RSPPPRLRGPQYVLNVTATDD-NAAGGALPLSSCAQVIVGI 651

  Fly  2545 ---NVYSPLFDQS---TYEAQVPENLLHGHNIITVKASDGDFGTYANLYYEIVSEE-MKKIFLID 2602
               |...|:||:.   :..|.|.||...|..::.|:|.|.|.|....:.|.|:..: ....|.|:
Zfish   652 NDINNNKPVFDECHNYSVNALVLENQPPGTFVLRVQAHDADTGVNGEVKYGIMQRDGASPGFTIN 716

  Fly  2603 QTTGVITSKVTFDREKKDEYVVLLKVSDGGGK--FGFASLKVIVVDVNDNVPYFLLKEYKMVVST 2665
            ..||||::.|:|||||:.||.:.:..:|...:  .|...:.|::.|.|||.|.|....|:..:..
Zfish   717 PDTGVISTAVSFDREKQREYTLSVTATDQAQEPLIGICQITVLIADQNDNDPKFENSRYQYFLRE 781

  Fly  2666 TVEANQTILTVKAKDDDIVDNGSVHFQIVQKSNDKAVKDVIEINEKTGDIVFKSKAESYGVNSYQ 2730
            ......:.|...|.|||...|.::.:.:.|::     .....||..||.|............|.|
Zfish   782 DTPVGTSFLRAAAHDDDQGTNSAITYSLSQQN-----PAYFHINPSTGWIYVNQPISQTSRISQQ 841

  Fly  2731 FFVRASDRGEPQFHSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHM---IGNYT 2792
              :.|:|.|...  |.|.:::.|.......|.:|::...:.|.|:||..|.:..:..   :|:..
Zfish   842 --IIATDGGSRS--SSVDLTVIITNVHNQPPQWEQAEYWVTIPENTPRDTKIVTIKATSPLGDPR 902

  Fly  2793 FKFSIAADQ-------DHFMI-----SDSGELILQQTLDREQQESHNLIV-VAETSTVPVFFAYA 2844
            ..:::...|       ..|.|     ..|..:::.:.||.|......|.| |...:.||: .::.
Zfish   903 VTYNLEEGQVPETNMPVRFYIKPNRRDGSASILVAENLDYETTGFFTLRVRVQNVAAVPL-ASFT 966

  Fly  2845 DVLIDVRDENDNYPKFDNTFYSASVAENSEKVISLVKVSATDADTGPNGDIRYYLESDTENIQNI 2909
            .|.:::.|.|||.|.|.::.|.|:|.|.:|...|:.:|||||.|:|.:|.|.|.:..|.......
Zfish   967 TVYVNITDVNDNVPFFMSSTYEATVPEGAEIGTSVAQVSATDLDSGLHGMINYIILKDQSGDSQF 1031

  Fly  2910 FDIDIYSGWITLLTSLDREVQSEYNFKVIAADN---------GHPKHDAKVPVTIKIVDYNDNAP 2965
            |.|:.|:|.|....:.|||.:..|..:|.:.|:         |.|..|... |.:.:.|.|||||
Zfish  1032 FSINSYTGIIHTRATFDREQKGSYLIEVQSQDSSESARPGQQGQPNTDTAY-VRVFVTDVNDNAP 1095

  Fly  2966 VFKLPIEGLSVFENALPGTVLINLLLIDPDI-EKQEMDFFIVSGDKQAQFQI-GKSGELFIAKPL 3028
            .|..|:..:||.|:...|.|:|.:...|.|. ...::.:.|.||:....|.: .:.|.:|||:.|
Zfish  1096 AFSQPVYEISVEEDKEVGFVVITVTANDEDEGANAKLRYQITSGNTMGTFDVEPEVGTIFIAQRL 1160

  Fly  3029 DREQLMFYNLSIIATDGKFTAKANVEIDVKDINDNTPYCLKPRYHISTNESIS-IGTTLVEVKAI 3092
            |.||:..|.|.::|:|||:..:..|.|:|.:.||..|...:..||.|..|.:: :...::||.|.
Zfish  1161 DYEQVQRYELRLVASDGKWENQTMVVINVINQNDEAPLFTQTEYHASVMEELTELPVLVLEVSAT 1225

  Fly  3093 DFD---FQSKLRFYLSGKGA-DDFSIGKESGILKVASALDRETTPKYKLVAHVQDGKDFTQECFS 3153
            |.|   .|..:|:.|.|:|| .:|:|.:.:|.:.....||||....::.:....|........|:
Zfish  1226 DPDQEADQRAVRYSLHGQGAGSEFTIDEINGRIFAQRRLDREVRSAWQFLVLATDENGAGLTGFA 1290

  Fly  3154 EIIITVNDINDNMPIFSMAQ---YRVSVPEDAQLNTLITKVHAMDKD---FGVNRQIKYSLMGE- 3211
            ::::.|.|||||.|:|..|.   :...|||::..:|.|.::.|.|.|   .|.|..:.|.::.. 
Zfish  1291 DVLVDVQDINDNAPVFLCATDNCFLGHVPENSPADTSIMEMRATDLDDPKAGKNAILTYRIVQNV 1355

  Fly  3212 ----NHDYFKISKSTG-IIRLHKSLDRETISLFNLTVKAEDCGVPKLHSIATVAVNILDINDNPP 3271
                |.:.|.|:.:|| |..:.:|||||.:..:.:.|:|.|.|  .|....|..:.|.|:||:||
Zfish  1356 RNEINLNLFSINPTTGTIYTVLRSLDREVVDRYLVVVEARDGG--GLSGTGTATIVISDVNDHPP 1418

  Fly  3272 EFSMRQYSCKILENATHGTEVCKVYATSIDIGVNADIHYFIMSGNEQGKFKMD----STTGDLVL 3332
            .|:.|.|...:.||....:||..|.||..|.|.|:.:.:.|:.|:|..||.::    :..|.:.|
Zfish  1419 VFTQRVYMASMSENLDINSEVMVVAATDGDEGENSVMTFSIIGGDEDRKFFIETDKVNRRGIVRL 1483

  Fly  3333 NATLDYEM--SKFYFLTIQAIDGGTPPLSNNAYVNISILDINDNSPTFLQNLYRI-NVNEDIFVG 3394
            ...:|:|.  .:.:.||::..|.....|   ||..|.:.|.||::|.|....|.. ::.||:.||
Zfish  1484 KKKIDFEKPHERTFNLTVKVEDADFFSL---AYCIIQVEDSNDHTPVFFPQFYEAGSMFEDVPVG 1545

  Fly  3395 SKILDVKATDEDSDVNGLVTYNI-ERGDNIGQFSIDPKNGTISVSRPLDRETISHYTLEIQACDQ 3458
            :.:..|.|.|.||..||..||:| ...|...||.:| |:|.:.|:..||||.::.:.|.|.|.|.
Zfish  1546 TIVAQVTAMDLDSGQNGRFTYSIAPESDPFQQFLVD-KSGWVVVADSLDREKVAQHRLMILATDM 1609

  Fly  3459 GDPQRCNSVPININILDTNDNAPIFSSSNYSVVLQENRLLGYVFLTFKIS------DADETPNTT 3517
            |.|....|..:.:.:.|.|||.|.|.:. |..::.||.:...|......|      |.|.:.|..
Zfish  1610 GSPALTGSAIVLVTVQDVNDNGPEFEAP-YRPIVWENTIAPQVIHMNDTSTLLHAIDRDTSSNGG 1673

  Fly  3518 PY-------TFDIRSGNEGGLFRLEQDGSLRTASR-FNHNLQDEFVIQVRVFDNGTPPLYSDAWV 3574
            |:       |.|:.:.|   |..:....::.||.| |:...|.::::.:.:.|:|:||:.|.:.:
Zfish  1674 PFSIRLLMLTSDVTNFN---LTDMRNGSAMITALRSFDREQQKQYLLPILMIDSGSPPMSSTSTL 1735

  Fly  3575 VVKIIEESQYPPIVTPLEVTINSFEDDFSGAFIGKVHASDQDKYDELNFSLVSGPDDMYQSSKLF 3639
            .|.|.:::.:|......|..:.:.:.......:|:|.:.|.|.:.|..:.....|      .:.|
Zfish  1736 TVIIGDKNDHPHAPGHSEFIVYNIQGTLPTTVLGQVQSPDLDDWSEKVYKFEGKP------PRQF 1794

  Fly  3640 NISNNTGKIYAISNLDIGLYKLNVSVSDGKF-HVFSIVKINVELVTNDMLKESVVIRFRRISASE 3703
            .::.|.|::........|||.|.|.|:|..: .|.|..::.|..:..:.|:.:..||...::|:|
Zfish  1795 ILNQNNGQLSVREGTAAGLYSLQVRVADKSWPDVTSSAEVTVMELQEEALRNAASIRLANLTANE 1859

  Fly  3704 FL---LSHRKTFMRSIRNIMRCRQKD---VILITLQSDYQKASQHAVGNRRARSIDSDLNVVFAV 3762
            |.   .:....:||..|.:....|.|   |.:.:|.|..|.|..|             |:|.||.
Zfish  1860 FFRASANEESRYMRLRRLLSELFQTDVENVDVFSLASGRQPAQHH-------------LSVWFAA 1911

  Fly  3763 RKQQIIPDSDEFFTSDEIRQTLIDKKNEIENETNLVVEDVLPSTCQSNKNDCVHGECKQI----L 3823
            .       ...::..:::...:...|.::|:...:.:       .|...::||:..|.|.    .
Zfish  1912 H-------GSPYYKPEKLHGYIAMHKAKLESALGVTI-------LQVGVDECVYAACGQTGGCSS 1962

  Fly  3824 QILKNNVTTTFTD----VISFAAPSYIPVNTCVCRPGFDGK-----HCKETVNACSTDPCSPQRI 3879
            ::..::..||..:    ::|.:|.:.:   .|.|.    |:     ||    ::.|..||.....
Zfish  1963 KVTFSDTPTTLNNGNISLVSVSAKASV---QCGCL----GRESVHLHC----SSYSQSPCLNGGT 2016

  Fly  3880 CMPSGSALGYQCVCPKGFSGTYCERKSSKCSNESCDMGLFTAVSFGGKSYAHYKINKVKAKFTLE 3944
            |:  .|.|||:|.||..|.|..|::               |..||.|..||.:  :.:|..|...
Zfish  2017 CV--DSELGYRCKCPPMFDGPECQQ---------------TKHSFLGNGYAWF--HPIKPCFQSH 2062

  Fly  3945 NGFSYSLQIRTVQQTGTLLYASG---------KVDYNILEIINGAVQYRFDLGSGEGVISVSS-I 3999
                .||:..|....|.|.| :|         |.|:..||:.||......:.|||...:.:|: .
Zfish  2063 ----ISLEFITEAANGLLFY-NGPMGAPQPREKEDFIALELKNGVPVLSVNHGSGTLTLQLSARA 2122

  Fly  4000 NISDGEWHQISLERSLNSAKVMVDNKHVS------------------------HGSAPGVNGILN 4040
            .::|..||.:.:.....|.::::|  |.|                        .|..||....|:
Zfish  2123 TVTDRRWHHLDIISDGKSVQMILD--HCSGAVVNEVEGLGVEMFETDQSVCKASGETPGSERFLD 2185

  Fly  4041 IQSNDIFVGAEV-----RPHPSIIGYEDIQRGFIGCMANIKIAKESLPLYISGGSTIAALKRFTN 4100
            :.......|.:.     |.||.       .:||:|||.|:.:..:...|..:..|...|      
Zfish  2186 VYQPLQLGGVKETHSLRRSHPH-------YKGFVGCMRNLVVDSQVYDLSSAAESENTA------ 2237

  Fly  4101 VEFKCDPSNVLVRLGIC---GSQPCANSGICKELDTDVFECACQPRYSGKHCEIDLDP------- 4155
                  |...|.. |:|   |...|...|.|.. :...|.|.|.|.|||..|:..|..       
Zfish  2238 ------PGCALTD-GVCLTAGGPSCGVHGRCLG-EWGSFSCDCHPGYSGHKCDKALPEWSFERDS 2294

  Fly  4156 ------------------------CSSGPCLFGGRCDYH------------------GPNNYSCT 4178
                                    .|:|..|.....|.:                  |...:|  
Zfish  2295 VLRYQLRGGGSPRRTQAHFLLRTRSSTGTLLSMASRDANEFIILEIVDGYLNVRANLGDGTHS-- 2357

  Fly  4179 CPIHLSGKRCEYGKF-------------------------------------------------- 4193
              :.|:|:|..:|::                                                  
Zfish  2358 --LKLTGQRVNHGQWVLISILRHDNIFILRLEQGGGSREVTGVLGQKKEIVVHPSSVFLGNSASP 2420

  Fly  4194 ----------------------------------------------CTPNPCKNGGICEEGDGIS 4212
                                                          |:..||.:...|.:.....
Zfish  2421 NTQGDFQGCMRDVRLNGHSLSLDGQSTEFSTVLERRGVVPGCHSDACSAKPCLSPLYCVDMWRKH 2485

  Fly  4213 HCMCRGYTGPTCEIDV-DE-----------CENQPCGNGATCI-NEPGSFRCICPSYLTGASCGD 4264
            .|.|     |..::.| ||           |....|.||.||: :...|::|.||....|..|  
Zfish  2486 ECRC-----PANQVAVLDEVTGLMRCAPSPCSASTCRNGGTCLAHSTKSYQCRCPEGFRGQWC-- 2543

  Fly  4265 PLYSNSISTKLKNFSIEHIS-GIISGVAVVLVIISCVLCCVVLKRSSSSKRRNRLEK 4320
                 .|. :||:..:..:| ..|..:::.|::...||..|.:.....|  ||:..|
Zfish  2544 -----EIG-QLKSLRLAALSPSSILAISMCLLVFFAVLVAVTVWNQKGS--RNKFRK 2592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
E_set 309..390 CDD:298831
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637
Cadherin_repeat 984..1082 CDD:206637
Cadherin_repeat 1092..1189 CDD:206637
Cadherin_repeat 1197..1295 CDD:206637
Cadherin_repeat 1303..1386 CDD:206637
Cadherin_repeat 1413..1502 CDD:206637
Cadherin_repeat 1510..1608 CDD:206637
Cadherin_repeat 1621..1713 CDD:206637
Cadherin_repeat 1724..1811 CDD:206637
Cadherin_repeat 1819..1927 CDD:206637
Cadherin_repeat 1948..2030 CDD:206637 13/65 (20%)
Cadherin_repeat 2037..2136 CDD:206637 26/127 (20%)
Cadherin_repeat 2144..2235 CDD:206637 23/90 (26%)
Cadherin_repeat 2246..2336 CDD:206637 27/93 (29%)
Cadherin_repeat 2345..2445 CDD:206637 34/103 (33%)
Cadherin_repeat 2453..2545 CDD:206637 27/107 (25%)
Cadherin_repeat 2555..>2633 CDD:206637 27/78 (35%)
Cadherin_repeat 2658..2759 CDD:206637 21/100 (21%)
Cadherin_repeat 2774..2856 CDD:206637 20/97 (21%)
Cadherin_repeat 2865..2963 CDD:206637 34/106 (32%)
Cadherin_repeat 2974..3063 CDD:206637 30/90 (33%)
Cadherin_repeat 3072..3165 CDD:206637 28/97 (29%)
Cadherin_repeat 3173..3269 CDD:206637 31/107 (29%)
Cadherin_repeat 3277..3374 CDD:206637 29/102 (28%)
Cadherin_repeat 3383..3479 CDD:206637 35/97 (36%)
Cadherin_repeat 3488..3579 CDD:206637 24/104 (23%)
Cadherin_repeat 3590..3681 CDD:206637 19/91 (21%)
EGF_CA 3866..3903 CDD:238011 13/36 (36%)
Laminin_G_2 3953..4077 CDD:280389 36/162 (22%)
EGF_CA <4121..4150 CDD:238011 10/28 (36%)
EGF_CA 4152..4189 CDD:238011 10/85 (12%)
EGF_CA 4195..4225 CDD:238011 6/29 (21%)
EGF_CA 4227..4262 CDD:214542 14/47 (30%)
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637 28/105 (27%)
Cadherin_repeat 355..447 CDD:206637 27/94 (29%)
Cadherin_repeat 461..549 CDD:206637 31/97 (32%)
Cadherin_repeat 558..657 CDD:206637 28/109 (26%)
Cadherin_repeat 668..766 CDD:206637 31/97 (32%)
Cadherin_repeat 775..863 CDD:206637 21/96 (22%)
Cadherin_repeat 874..978 CDD:206637 21/104 (20%)
Cadherin_repeat 986..1093 CDD:206637 34/107 (32%)
Cadherin_repeat 1101..1194 CDD:206637 29/92 (32%)
Cadherin_repeat 1203..1302 CDD:206637 28/98 (29%)
Cadherin_repeat 1317..1416 CDD:206637 31/100 (31%)
Cadherin_repeat 1424..1524 CDD:206637 29/102 (28%)
Cadherin_repeat 1533..1630 CDD:206637 35/97 (36%)
Cadherin_repeat 1637..1745 CDD:206637 25/111 (23%)
Cadherin_repeat 1756..1836 CDD:206637 18/85 (21%)
EGF_CA 2003..2038 CDD:238011 14/40 (35%)
LamG 2062..2223 CDD:214598 38/174 (22%)
EGF_CA 2247..2281 CDD:238011 12/34 (35%)
Laminin_G_2 2315..2438 CDD:280389 10/126 (8%)
EGF_CA 2512..2544 CDD:238011 11/38 (29%)
Cadherin_C 2602..2758 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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