DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and Angpt1

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_006241671.1	Gene:	Angpt1 / 89807	RGDID:	628896	Length:	498	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	118/498 - (23%)
Similarity:	199/498 - (39%)	Gaps:	142/498 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DQNNFSQNSRSSPDSSTENNSSSSDSEMEFVGTSARGMLKHKKKDERKISELTRKLAEAEI-NLK 68
            :|.|.:...|.:|...|:.:|..               |:|.:......::..:||....: |:|
  Rat    60 EQYNTNALQRDAPHVETDFSSQK---------------LQHLEHVMENYTQWLQKLENYIVENMK 109

  Fly    69 AQQEKGSILENCIKDKDDFIKTLQLSIDLVTQTKEMT--IQKLQTQIMDLQSDLDLSRITIKKND 131
            :  |...|.:|.:::..  ...|::...|::||.|.|  :..::||:::..|.|::..:
  Rat   110 S--EMAQIQQNAVQNHT--ATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLL------ 164

  Fly   132 GGNCAPAHDKVVKERKELNMENGKFREGNDQIVEIEKILNSKEAEIARLEFKIDESKLKIVQLEG 196
                                      |.:....::||.|..:..||.:::.|....:.||:::||
  Rat   165 --------------------------ENSLSTYKLEKQLLQQTNEILKIQEKNSLLEHKILEMEG 203

  Fly   197 AVK-----AKDEK------IVKMTEILSEYN------VNNKD-------------HD-------E 224
            ..|     .|:||      :.:.|.|:.|..      .||..             |:       |
  Rat   204 KHKEELDTLKEEKENLQGLVTRQTFIIQELEKQLSRATNNNSVLQKQQLELMDTVHNLVSLCTKE 268

  Fly   225 FVLLGSSK----------------------LPSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRR 267
            .|||...|                      :.:|....:|  || ..||.::...|.||.:||.|
  Rat   269 GVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYFNNMP--EP-KKVFCNMDVNGGGWTVIQHR 330

  Fly   268 IDGSFD-NATESNIITGCGDLGGEFWLGLQKLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIG 331
            .|||.| .........|.|:..||:|||.:.:..:|:.|:..|.|:|:|::...||::||.|.||
  Rat   331 EDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIG 395

  Fly   332 DEKQKYKLLSLGEYSGNAGDAFRSHINHIIVGNPFA---------------MESSKWWGTMNC-- 379
            :|||.|:|...| ::|.||    ...:.|:.|..|:               |.:..||... |
  Rat   396 NEKQNYRLYLKG-HTGTAG----KQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDA-CGP 454

  Fly   380 -NLNGKYRNSKVELDTTDGIWWGNWNVGNRYPLKSCKMLIRPM 421
             ||||.:..:.......:||.| ::..|..|.|:|..|:|||:
  Rat   455 SNLNGMFYTAGQNHGKLNGIKW-HYFKGPSYSLRSTTMMIRPL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	16/76 (21%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	64/194 (33%)
Angpt1	XP_006241671.1	COG4372	<55..>255	CDD:226809	45/245 (18%)
Angpt1	XP_006241671.1	FReD	281..496	CDD:238040	66/224 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000