DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and TNR

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_003276.3	Gene:	TNR / 7143	HGNCID:	11953	Length:	1358	Species:	Homo sapiens

Alignment Length:	290	Identity:	81/290 - (27%)
Similarity:	131/290 - (45%)	Gaps:	48/290 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 EIEK-ILNSKEAEIARLEFKIDESKLKIVQLEGAVKAKDEKI------------VKMTEILSEYN 216
            |||. :|..|..:.:|.|..:|.....| :|||.::..|..:            :..|...:...
Human  1067 EIENYVLTYKSTDGSRKELIVDAEDTWI-RLEGLLENTDYTVLLQAAQDTTWSSITSTAFTTGGR 1130

  Fly   217 V--NNKDHDEFVLLGSSKLPSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRRIDGSFDNATE-S 278
            |  :.:|..:.::.|.:......:....:......|:.|:.:.|.||::.|||.:|..|...: :
Human  1131 VFPHPQDCAQHLMNGDTLSGVYPIFLNGELSQKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWA 1195

  Fly   279 NIITGCGDLGGEFWLGLQKLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLG 343
            :...|.|::..||||||..:|::|:..|.||.:.:.|...| |:|.||.|.:.|.:..|| |.:|
Human  1196 DYRVGFGNVEDEFWLGLDNIHRITSQGRYELRVDMRDGQEA-AFASYDRFSVEDSRNLYK-LRIG 1258

  Fly   344 EYSGNAGDAFRSHINHIIVGNPFAME---------------SSKWWGTMNC---NLNGKYRNSKV 390
            .|:|.|||:...|     .|.||:.|               ...|| ..||   ||||||..|:
Human  1259 SYNGTAGDSLSYH-----QGRPFSTEDRDNDVAVTNCAMSYKGAWW-YKNCHRTNLNGKYGESR- 1316

  Fly   391 ELDTTDGIWWGNWNVGNRYPLKSCKMLIRP 420
               .:.||.|.:|. |:.:.:...:|.:||
Human  1317 ---HSQGINWYHWK-GHEFSIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	14/59 (24%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	64/195 (33%)
TNR	NP_003276.3	EGF_2	<208..230	CDD:285248
		EGF_2	267..292	CDD:285248
		EGF_2	299..323	CDD:285248
		fn3	328..398	CDD:278470
		fn3	416..496	CDD:278470
		fn3	505..583	CDD:278470
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:278470
		fn3	776..855	CDD:278470
		fn3	865..944	CDD:278470
		fn3	954..1026	CDD:278470
		FN3	1042..1127	CDD:238020	14/60 (23%)
		FReD	1133..1342	CDD:238040	64/221 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810