DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and Fga

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001008724.1	Gene:	Fga / 361969	RGDID:	2603	Length:	782	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	119/496 - (23%)
Similarity:	193/496 - (38%)	Gaps:	116/496 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NFSQNSRSSPDSSTENNSSSSDSEMEFVGTSARGMLKHKKKDERKISEL-------TRKLAEAEI 65
            |:...:..|.|:.|....||..|       |..|.||....|..:.||.       |||
  Rat   318 NWGSGTTGSDDTGTWGAGSSRPS-------SGSGNLKPSNPDWGEFSEFGGSSSPATRK------ 369

  Fly    66 NLKAQQEKGSILENCIKDKDDFIKTLQLSIDLVTQTKEMTIQK-----LQTQIMDLQSDLDLSRI 125
                :...|.:    :..|.|  |.|.:..:.||.|...|.::     :...::......::.:.
  Rat   370 ----EYHTGKL----VTSKGD--KELLIGNEKVTSTGTSTTRRSCSKTITKTVLGNDGHREVVKE 424

  Fly   126 TIKKNDGGNCAPAHD--------KVVKERKELNMENGKFREG------------------NDQIV 164
            .:..:||.:|....|        ..:.|...::.|.|.|.:.                  :|...
  Rat   425 VVTSDDGSDCGDGMDLGLTHSFSGRLDELSRMHPELGSFYDSRFGSLTSNFKEFGSKTSDSDIFT 489

  Fly   165 EIEKILN-----SKEAEIARLEFKIDESKLKIVQLEGAVKAKDEKIVKMTEILSEYNVNNKDHDE 224
            :||...:     |..::.:.:..::.:| .|:.. |.|.:|..|...:.|:......:.:.| |.
  Rat   490 DIENPSSHVPEFSSSSKTSTVRKQVTKS-YKMAD-EAASEAHQEGDTRTTKRGRARTMRDCD-DV 551

  Fly   225 FVLLGSSKLPSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRRIDGSFD-NATESNIITGCGDLG 288
            .....|.....|..:.||......||:.|..::..||::||:|:|||.: |.|..:...|.|.|.
  Rat   552 LQTHPSGAQNGIFSIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLN 616

  Fly   289 ----GEFWLGLQKLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLGEYSGNA 349
                ||||||...||.:|. |...|.::|.|:....|||.| :|.:|.|.:.| .|.:..|.|.|
  Rat   617 DKGEGEFWLGNDYLHLLTL-RGSVLRVELEDWAGKEAYAEY-HFRVGSEAEGY-ALQVSSYQGTA 678

  Fly   350 GDA-----------FRSHINHIIVGNPFAMESSKW-----------WGTMNC---NLNGKY---- 385
            |||           :.||.|  :..:.|..::.:|           |...:|   ||||.|
  Rat   679 GDALMEGSVEEGTEYTSHSN--MQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGG 741

  Fly   386 -----RNSKVELDTTDGIWWGNWNVGNRYPLKSCKMLIRPM 421
                 .||..|::  :|:.|..:. |..|.|::.:|.|||:
  Rat   742 TYDPRNNSPYEIE--NGVVWVPFR-GADYSLRAVRMKIRPL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	14/88 (16%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	67/214 (31%)
Fga	NP_001008724.1	Fib_alpha	51..189	CDD:285864
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..374		17/72 (24%)
		Fibrinogen_aC	388..453	CDD:288972	8/64 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..542		5/20 (25%)
		FReD	546..779	CDD:238040	73/241 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900