DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and TNC

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	217	Identity:	66/217 - (30%)
Similarity:	104/217 - (47%)	Gaps:	26/217 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 KDHDEFVLLGSSKLPSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRRIDGSFDNATES--NIIT 282
            ||..:.:|.|.:......:....|......||.|:.|.|.||::..||.:|. :|..::  ....
Human  2165 KDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGR-ENFYQNWKAYAA 2228

  Fly   283 GCGDLGGEFWLGLQKLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLGEYSG 347
            |.||...||||||..|:|:|...:.||.:.|.| ...:|:|.||.|.:||.|.:|||...| |||
Human  2229 GFGDRREEFWLGLDNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEG-YSG 2291

  Fly   348 NAGDAFRSH-----------INHIIVGNPFAMESSKWWGTMNC---NLNGKYRNSKVELDTTDGI 398
            .|||:...|           .:..|.....:.:.:.|:  .||   ||.|:|.::    :.:.|:
Human  2292 TAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWY--RNCHRVNLMGRYGDN----NHSQGV 2350

  Fly   399 WWGNWNVGNRYPLKSCKMLIRP 420
            .|.:|. |:.:.::..:|.:||
Human  2351 NWFHWK-GHEHSIQFAEMKLRP 2371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814
CG7668	NP_649170.1	FReD	245..421	CDD:294064	61/192 (32%)
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572	66/217 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900