DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7668 and Angptl3

DIOPT Version :9

Sequence 1:NP_649170.1 Gene:CG7668 / 40190 FlyBaseID:FBgn0036929 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_038941.1 Gene:Angptl3 / 30924 MGIID:1353627 Length:455 Species:Mus musculus


Alignment Length:463 Identity:115/463 - (24%)
Similarity:199/463 - (42%) Gaps:81/463 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SRSSPDSSTENNSSSSDSE----MEFVGTSARGMLK---------HKKKDERKISELTRKLAEAE 64
            ||..||.|:.:::.|....    ::.|...|.|:|:         ||.|.:  |:::.:||    
Mouse    17 SRVDPDLSSFDSAPSEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQ--INDIFQKL---- 75

  Fly    65 INLKAQQEKG-SILENCIKDKDDFIK----TLQ--------LSIDLVTQTKEMTIQK--LQTQIM 114
             |:..|.... |:..|.||:::..::    |||        :|::|.::.:.:..:|  ||.::.
Mouse    76 -NIFDQSFYDLSLRTNEIKEEEKELRRTTSTLQVKNEEVKNMSVELNSKLESLLEEKTALQHKVR 139

  Fly   115 DLQSDLDLSRITIKKNDGGNCAPAHDKVVKERKELNMENGKFREGNDQIVEIEKILNSKEAEIAR 179
            .|:..|    ..:..:..|  |..|.:|...:..:..::...||....:.|..|.|:.:..:|..
Mouse   140 ALEEQL----TNLILSPAG--AQEHPEVTSLKSFVEQQDNSIRELLQSVEEQYKQLSQQHMQIKE 198

  Fly   180 LEFKIDESKLKIVQLEGAVKAKDEKIVKMTEILSEYNVNNKDHDEFVLLGSSKLPSIKLVTLPDF 244
            :|.::.::.:: ...|.::.:| .:..:.|..|......|.:.|:        ||:.........
Mouse   199 IEKQLRKTGIQ-EPSENSLSSK-SRAPRTTPPLQLNETENTEQDD--------LPADCSAVYNRG 253

  Fly   245 EPFASVFEDIP------------SAGRGWMIIQRRIDGSFD-NATESNIITGCGDLGGEFWLGLQ 296
            |..:.|:...|            .:|..|.:||.|.|||.| |.|..|...|.|.|.|||||||:
Mouse   254 EHTSGVYTIKPRNSQGFNVYCDTQSGSPWTLIQHRKDGSQDFNETWENYEKGFGRLDGEFWLGLE 318

  Fly   297 KLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLGEYSGNAGDAFRSHI---- 357
            |::.:.......|.::|.|:.::..|..| :|.:|..:..| .|.:.|.:||...|...|.    
Mouse   319 KIYAIVQQSNYILRLELQDWKDSKHYVEY-SFHLGSHETNY-TLHVAEIAGNIPGALPEHTDLMF 381

  Fly   358 ---NHIIVGNPFAME--SSKWWGTMNC---NLNGKYR--NSKVELDTTDGIWWGNWNVGNRYPLK 412
               ||...|..:..|  |..||....|   ||||||.  .:|...:...||:|...: ...|.:|
Mouse   382 STWNHRAKGQLYCPESYSGGWWWNDICGENNLNGKYNKPRTKSRPERRRGIYWRPQS-RKLYAIK 445

  Fly   413 SCKMLIRP 420
            |.||:::|
Mouse   446 SSKMMLQP 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7668NP_649170.1 DUF16 146..>212 CDD:279814 10/65 (15%)
FReD 245..421 CDD:294064 64/203 (32%)
Angptl3NP_038941.1 Sufficient to inhibit LIPG/EL phospholipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1 17..207 43/202 (21%)
Sufficient to inhibit LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1, ECO:0000269|PubMed:20581395 17..165 36/160 (23%)
Required for inhibition of LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1 32..56 4/23 (17%)
SPEC <34..191 CDD:295325 35/169 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..242 6/49 (12%)
FReD 241..453 CDD:238040 65/222 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2579
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19143
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.000

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