DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and tnn

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_005171321.1	Gene:	tnn / 30234	ZFINID:	ZDB-GENE-990415-262	Length:	1020	Species:	Danio rerio

Alignment Length:	449	Identity:	117/449 - (26%)
Similarity:	175/449 - (38%)	Gaps:	132/449 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSPDSSTENNSSSSDS-EMEFVGTSARGMLKHKKKDERKISELTRKL---AEAEI----NLKAQQ 71
            ||.|.|.:.....:|| ...|.|... |:|........|.|..:||.   ||.||    ||||
Zfish   645 SSLDGSGQEVRVGADSISYRFTGLKP-GVLYTVSVWAVKGSRSSRKATTEAETEIDAPKNLKA-- 706

  Fly    72 EKGSILENCIKDKDDFIKTLQLSIDLVTQTKEMTIQKLQTQIMDLQSDLDLSRITIKKNDGGNCA 136
                                   .|:.|||..:|.:.       .|::::...:|.:..||
Zfish   707 -----------------------TDVQTQTSTLTWKA-------PQANIEGYILTYRAEDG---- 737

  Fly   137 PAHDKVVKERKELNMENGKFREGNDQIVEIEKILNSKEAEIARLEFKIDESKLKIVQLEGAVKAK 201
                         :|:.            :||.|.::|...|.  ..::..|..||.|.....:|
Zfish   738 -------------SMQT------------VEKTLTARENRFAL--SGLEMGKKYIVTLIAYRGSK 775

  Fly   202 DEKIVK---------------MTEILSEYNVNNKDHDEFVLLGSSKLPSIKLVTLPDFEPFASVF 251
            ..|||:               .|:|:...|:.:..:..:|....|:.              ..|:
Zfish   776 RSKIVETTFSTVGLAYQFPMDCTQIMRNGNMESGVYTIYVNNNRSRT--------------MQVY 826

  Fly   252 EDIPSAGRGWMIIQRRIDGSFDNATE-SNIITGCGDLGGEFWLGLQKLHKMT-THRRMELYIQLV 314
            .|:.:.|.||::.|||..|..|...: .:.:.|.|:|..||||||.|:|::| |..:.|     .
Zfish   827 CDMKTDGGGWIVFQRRNTGKVDFMKKWRDYMKGFGELTEEFWLGLDKIHELTNTPTQYE-----A 886

  Fly   315 DFDNASA----YARYDNFVIGDEKQKYKLLSLGEYSGNAGDAFRSH----------INHIIVGNP 365
            .||..|.    ||.||||.:...|||:| |::|.|.||||||...|          .|.|.:||.
Zfish   887 RFDLGSGSDRKYAVYDNFKVAPSKQKFK-LTIGSYKGNAGDAMTYHQGAPFSTVDSDNDIALGNC 950

  Fly   366 FAMESSKWWGTMNC---NLNGKYRNSKVELDTTDGIWWGNWNVGNRYPLKSCKMLIRPM 421
            .......|| ..||   ||||::.:::..:    |:.|..|. |:...|...::.|||:
Zfish   951 ALTHQGAWW-YKNCHLANLNGRFGDNRHSM----GVNWEPWK-GHLQSLDFAEIKIRPV 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	15/80 (19%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	66/194 (34%)
tnn	XP_005171321.1	EGF_alliinase	<133..163	CDD:282688
		EGF_2	161..189	CDD:285248
		EGF_2	193..220	CDD:285248
		EGF_2	224..251	CDD:285248
		fn3	257..333	CDD:278470
		fn3	344..426	CDD:278470
		fn3	435..514	CDD:278470
		fn3	523..602	CDD:278470
		fn3	611..683	CDD:278470	10/38 (26%)
		fn3	699..773	CDD:278470	23/136 (17%)
		FReD	792..1003	CDD:238040	71/236 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000