DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and FGL2

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_006673.1	Gene:	FGL2 / 10875	HGNCID:	3696	Length:	439	Species:	Homo sapiens

Alignment Length:	343	Identity:	101/343 - (29%)
Similarity:	160/343 - (46%)	Gaps:	66/343 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IQKLQTQIMDLQSDLDLSRITIKKNDGGNCAPAHDKVVKERKELNMENGKFREGNDQIVEIEKIL 170
            :::|::::..|.|:|        ||              .::|:|:.:|:..:.|  :|.:..|.
Human   130 VRELESEVNKLSSEL--------KN--------------AKEEINVLHGRLEKLN--LVNMNNIE 170

  Fly   171 NSKEAEIARLEFKIDESKLKIVQLEGAVKAKDEKIVKMTEILSE--YNVNNKDHDEFVLLGSSKL 233
            |..::::|.|.|.::       .|:|    |..|.....:|.|.  .::..||..::..:|....
Human   171 NYVDSKVANLTFVVN-------SLDG----KCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSS 224

  Fly   234 PSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRRIDGSFD-NATESNIITGCGDLGGEFWLGLQK 297
            .:.::...|....| .|:.|:.:.|.||.::|.|:|||.: ..|..:...|.|:|..|||||..|
Human   225 ETYRVTPDPKNSSF-EVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDK 288

  Fly   298 LHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLGEYSGNAGDA--FRSHINHI 360
            :|.:|..:.|.|.|.|.||:....||.||.|.:.:|..||: |.:|.|:|.||||  |..|.||.
Human   289 IHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYR-LHVGNYNGTAGDALRFNKHYNHD 352

  Fly   361 I--------------VGNPFAMESSKWW--GTMNCNLNGKYRNSKVELDTTDGIWWGNW-NVGNR 408
            :              .||.....||.||  ..::.||||||.:.|.. ...:||:||.| .|...
Human   353 LKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYR-GVRNGIFWGTWPGVSEA 416

  Fly   409 YP------LKSCKMLIRP 420
            :|      .|..||:|||
Human   417 HPGGYKSSFKEAKMMIRP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	14/65 (22%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	75/202 (37%)
FGL2	NP_006673.1	DUF460	<28..>161	CDD:331991	9/52 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..126
		FReD	209..435	CDD:294064	79/229 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810