DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7668 and tnxba

DIOPT Version :9

Sequence 1:	NP_649170.1	Gene:	CG7668 / 40190	FlyBaseID:	FBgn0036929	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_021322558.1	Gene:	tnxba / 100536295	ZFINID:	ZDB-GENE-070103-5	Length:	2285	Species:	Danio rerio

Alignment Length:	484	Identity:	116/484 - (23%)
Similarity:	186/484 - (38%)	Gaps:	129/484 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ENNSSSSDSEMEFV-------GTS---ARGMLKHKKKDERKISELTRKLAEAEINLKA---QQEK 73
            |:.|.|.||::..|       ||:   ....:..|.:.|..|:.:| .:.::...||.   ...|
Zfish  1831 ESGSMSVDSQLSHVLLSKLTAGTTYDITVSSVLDKLESEPVIASIT-TVPDSPTELKVVNITDTK 1894

  Fly    74 GSILENCIKDK-DDFIKTLQLSIDL-----VTQTKEMTIQKLQTQIMDL-QSDLDLSRITIKKND 131
            ..::....|.| |.:|    ||...     ||.|..::...::.|:..| :|.|.:.::|.:.|
Zfish  1895 ALLVWKPSKAKVDSYI----LSYGTTKSPNVTITVTLSGSSVEHQLRALHRSSLYMVKMTSQVN- 1954

  Fly   132 GGNCAPAHDKVVKERKELNMENGKFREGN---------DQIVEIEKILNSKEAEIA----RLEFK 183
                          |.:.:..:..|..|:         |::.....:::.|...:|    ||.::
Zfish  1955 --------------RLQSSSVSTSFTTGSGVKLQVVTPDEVTFHSAVISWKAPRVAFKSYRLTYQ 2005

  Fly   184 IDESKLKIV--------QLEG-------AVKAKDEKIVKMTEIL-----------------SEYN 216
            :.|...:::        :|.|       .||...|:..:....:                 ||..
Zfish  2006 LSEEVKELILNPSVTHYELTGLAAFSNYTVKIDGERDGQYISFVSSDFTTAQLPHPYPTDCSEVQ 2070

  Fly   217 VNN-KDHDEFVLLGSSKLPSIKLVTLPDFEPFASVFEDIPSAGRGWMIIQRRIDGSFD-NATESN 279
            :|. |:..|..:....|          :.|| ..|:.|:.:.|..|.:.|||:|||.| ..:..:
Zfish  2071 INGMKESGEAEIYPEGK----------NGEP-VRVYCDMETDGGAWTVFQRRMDGSTDFFRSWRD 2124

  Fly   280 IITGCGDLGGEFWLGLQKLHKMTTHRRMELYIQLVDFDNASAYARYDNFVIGDEKQKYKLLSLGE 344
            ...|.|.|.||||||...||.:|:.:.|.|.|.|.. .|.:|:|:|.||.|..|...| .:.|..
Zfish  2125 YSKGFGLLSGEFWLGNDVLHTLTSLKAMSLRIDLRS-GNDTAFAQYINFNISSEANHY-AIDLSG 2187

  Fly   345 YSGNAGDAFRSHINHIIVGNPFAMESSK---------------WWGTMNC---NLNGKYRNSKVE 391
            |||.|||:.:.|     .|.||:.:...               || ..||   ||||.|    ..
Zfish  2188 YSGTAGDSMKYH-----KGRPFSTKDKDPDTLSIHCAKAYMGGWW-YKNCYKANLNGLY----AS 2242

  Fly   392 LDTTDGIWWGNWNVGNRYPLKSCKMLIRP 420
            .....|:.|.:|. |....|...:|.:||
Zfish  2243 YSDNKGVVWIDWK-GKDASLPFTEMKLRP 2270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7668	NP_649170.1	DUF16	146..>212	CDD:279814	14/93 (15%)
CG7668	NP_649170.1	FReD	245..421	CDD:294064	66/195 (34%)
tnxba	XP_021322558.1	COG3942	596..>913	CDD:332523
		EGF_2	1380..1406	CDD:285248
		fn3	1792..1870	CDD:306538	9/38 (24%)
		fn3	1880..1952	CDD:306538	17/75 (23%)
		fn3	1976..2037	CDD:306538	9/60 (15%)
		FReD	2061..2270	CDD:238040	70/232 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19143
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100