Protein Alignment Gabat and AGXT2

DIOPT Version :10

• Sequence 1: NP_649168.2
• Gene: Gabat / 40188
• FlyBaseID: FBgn0036927
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_114106.1
• Gene: AGXT2 / 64902
• HGNCID: 14412
• Length: 514
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 118/517 - (22%)
• Similarity: 206/517 - (39%)
• Gaps: 94/517 - (18%)

  Fly    16 RLSTKRYSTNVEPKEPVV-----KTKSIPGPKSIELKKQLDSVQATGTIQFFADYEKSIGNYIYD 75
            |.|..:.|.:.:|:.|..     :.:|:...:.:|:.|:..|...|...|......:....:::|
Human    34 RTSVTKLSLHTKPRMPPCDFMPERYQSLGYNRVLEIHKEHLSPVVTAYFQKPLLLHQGHMEWLFD 98

  Fly    76 VDGNILLDVYTQISSVPLGYNHPRLYKVFNNE----QNLKTLINRPALGVFPGKEWPEKLHSVLL 136
            .:|:..||.::.|.:|.:|:.||::..|...:    .:..|:...|     |..|:.|||.::|
Human    99 AEGSRYLDFFSGIVTVSVGHCHPKVNAVAQKQLGRLWHTSTVFFHP-----PMHEYAEKLAALL- 157

  Fly   137 NIAPKGLNKITTMMCGSCSNENAYKSIFIWYQNKLRGNAPLTEQEKNSCMINIPPGAPKLSILSF 201
               |:.|..|..:..||.:||.|                          |:.....:..:.|:||
Human   158 ---PEPLKVIFLVNSGSEANELA--------------------------MLMARAHSNNIDIISF 193

  Fly   202 KGAFHG---RTLGALSTTHSKYIHKLDVPSFD--WPIASFPEYRYP------LDENVAHNKK--- 252
            :||:||   .|||..:..    .:|:::|...  .|......:|.|      .|..|...:|
Human   194 RGAYHGCSPYTLGLTNVG----TYKMELPGGTGCQPTMCPDVFRGPWGGSHCRDSPVQTIRKCSC 254

  Fly   253 ------EDEKCLSEVQDLIQQYASKNPVAGIVVEPIQSEGGDNEASPEFFRSLQAICKKNGIALL 311
                  ..::.:.:.:|.:....:|: :||...||||...|..:....|.:....:.:..|...:
Human   255 APDCCQAKDQYIEQFKDTLSTSVAKS-IAGFFAEPIQGVNGVVQYPKGFLKEAFELVRARGGVCI 318

  Fly   312 IDEVQTGGGSTGK-FWAHEHFELESPPDVVTFSKKLQLGGYFHNDDFIPN--------EPYRIFN 367
            .||||||.|..|. ||..:..::  .||:||.:|  .:|..|.....|..        :..:.||
Human   319 ADEVQTGFGRLGSHFWGFQTHDV--LPDIVTMAK--GIGNGFPMAAVITTPEIAKSLAKCLQHFN 379

  Fly   368 TWMGDPGKVLLLEEVVKVIQEEKLLANVDVAGKVLKNGLLSLEKEFPHILNSTRGRGTFLAVNCT 432
            |:.|:|....:...|::||:||.|..|....|..:......|..|| .|:...||:|..:.:...
Human   380 TFGGNPMACAIGSAVLEVIKEENLQENSQEVGTYMLLKFAKLRDEF-EIVGDVRGKGLMIGIEMV 443

  Fly   433 NTKVR---------DQIIGALKLHGIQTGGCGEISIRFR--PALIFKEYHANIVLDRFRKVL 483
            ..|:.         :||....|..|:..|.....|..||  |::...:...:..::.||..|
Human   444 QDKISCRPLPREEVNQIHEDCKHMGLLVGRGSIFSQTFRIAPSMCITKPEVDFAVEVFRSAL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gabat	NP_649168.2	AAT_I	27..483	CDD:450240	114/504 (23%)
AGXT2	NP_114106.1	ArgD	66..507	CDD:439930	112/485 (23%)