DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gabat and abat

DIOPT Version :9

Sequence 1:	NP_001163479.1	Gene:	Gabat / 40188	FlyBaseID:	FBgn0036927	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_958906.2	Gene:	abat / 378968	ZFINID:	ZDB-GENE-031006-4	Length:	500	Species:	Danio rerio

Alignment Length:	469	Identity:	271/469 - (57%)
Similarity:	345/469 - (73%)	Gaps:	3/469 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RLSTKRYSTNVEPKEPVVKTKSIPGPKSIELKKQLDSVQATGTIQFFADYEKSIGNYIYDVDGNI 80
            :.:||..| ..|...|.:|| ::|||||.||.:||..:|.||.|.||.:||:|.|||:.|||||.
Zfish    30 KTATKTVS-EFEYDAPSMKT-TVPGPKSKELLRQLGEIQNTGAIHFFCNYEESRGNYLVDVDGNR 92

  Fly    81 LLDVYTQISSVPLGYNHPRLYKVFNNEQNLKTLINRPALGVFPGKEWPEKLHSVLLNIAPKGLNK 145
            :|||||||||:|:|||||.|.||..|..|:...:||||||:.|.:.:||||...||:|||.|:.|
Zfish    93 MLDVYTQISSIPIGYNHPALMKVMTNPNNVSAFVNRPALGILPPENFPEKLAESLLSIAPSGMTK 157

  Fly   146 ITTMMCGSCSNENAYKSIFIWYQNKLRGNAPLTEQEKNSCMINIPPGAPKLSILSFKGAFHGRTL 210
            :.||.|||||||||:||:||||:||.||.|..:|:|..:||:|..||.|.||||||.||||||||
Zfish   158 VQTMACGSCSNENAFKSMFIWYRNKERGYATPSEEEVGTCMVNQSPGCPDLSILSFMGAFHGRTL 222

  Fly   211 GALSTTHSKYIHKLDVPSFDWPIASFPEYRYPLDENVAHNKKEDEKCLSEVQDLIQQYASK-NPV 274
            |.|:|||||.|||||:||||||||.||:.||||:|....|.:|:.:||.||:|||.::..| .||
Zfish   223 GCLATTHSKAIHKLDIPSFDWPIAPFPKLRYPLEEFERENAQEEARCLEEVEDLIVKWRQKGKPV 287

  Fly   275 AGIVVEPIQSEGGDNEASPEFFRSLQAICKKNGIALLIDEVQTGGGSTGKFWAHEHFELESPPDV 339
            ||||:||||:|||||.|||:||..|:.|.:|:|....:||||||||:|||||||||:.|:.|.|:
Zfish   288 AGIVIEPIQAEGGDNHASPDFFIKLRNIARKHGCGFHVDEVQTGGGATGKFWAHEHWGLDDPADL 352

  Fly   340 VTFSKKLQLGGYFHNDDFIPNEPYRIFNTWMGDPGKVLLLEEVVKVIQEEKLLANVDVAGKVLKN 404
            |:||||:..|||||.|:..|::||||||||||||.|.|.|.||:.||:.|.||..|..:||.|..
Zfish   353 VSFSKKMLTGGYFHRDELQPDKPYRIFNTWMGDPSKNLFLSEVLNVIRRENLLEQVTRSGKALLQ 417

  Fly   405 GLLSLEKEFPHILNSTRGRGTFLAVNCTNTKVRDQIIGALKLHGIQTGGCGEISIRFRPALIFKE 469
            ||.:|:.::||:|:..||:|||.|:|.::...||.|:...:..|:..|.|||.||||||||:|||
Zfish   418 GLYALQSQYPHLLSGARGQGTFCAINASSDATRDSIMLKARNKGVFLGSCGEKSIRFRPALVFKE 482

  Fly   470 YHANIVLDRFRKVL 483
            ||.:.:|:....||
Zfish   483 YHVHQLLNILNDVL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabat	NP_001163479.1	GabT	27..484	CDD:223238	268/458 (59%)
Gabat	NP_001163479.1	AAT_I	27..483	CDD:302748	266/456 (58%)
abat	NP_958906.2	AAT_I	38..496	CDD:302748	266/458 (58%)
abat	NP_958906.2	GabT	42..500	CDD:223238	267/456 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576189
Domainoid	1	1.000	539	1.000	Domainoid score	I259
eggNOG	1	0.900	-	-		E1_COG0160
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H542
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1053
OMA	1	1.010	-	-		QHG55983
OrthoDB	1	1.010	-	-		D222188at33208
OrthoFinder	1	1.000	-	-		FOG0005369
OrthoInspector	1	1.000	-	-		oto39851
orthoMCL	1	0.900	-	-		OOG6_103520
Panther	1	1.100	-	-	LDO	PTHR43206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R468
SonicParanoid	1	1.000	-	-		X3808
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800