DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gabat and gta-1

DIOPT Version :9

Sequence 1:	NP_001163479.1	Gene:	Gabat / 40188	FlyBaseID:	FBgn0036927	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_501862.1	Gene:	gta-1 / 177897	WormBaseID:	WBGene00001794	Length:	483	Species:	Caenorhabditis elegans

Alignment Length:	484	Identity:	239/484 - (49%)
Similarity:	326/484 - (67%)	Gaps:	5/484 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNTLTKQSLYRLSTKRYS--TNVEPKEPVVKTKSIPGPKSIELKKQLDSVQATGTIQFFADYEKS 68
            |..|.|.||.: ..:..|  .|.||..|.:.| |||||||..||:::|.|..|.:::|..|||||
Worm     2 LPRLAKSSLIQ-QVRGVSAIANAEPSGPSIST-SIPGPKSKALKQEMDKVHQTTSVRFHVDYEKS 64

  Fly    69 IGNYIYDVDGNILLDVYTQISSVPLGYNHPRLYKVFNNEQNLKTLINRPALGVFPGKEWPEKLHS 133
            .|||:.|.|||.||||||||||:|||||||.|.||.:....:.:|::|||||.||..::.:.:..
Worm    65 FGNYVVDADGNALLDVYTQISSLPLGYNHPDLVKVASQPHLITSLVSRPALGSFPRTDFADGISH 129

  Fly   134 VLLNIAPKGLNKITTMMCGSCSNENAYKSIFIWYQNKLRGNAPLTEQEKNSCMINIPPGAPKLSI 198
            .|.:||||||..:.||:||:.:||||.|:.|||||.:.||..........|||....||.|.||:
Worm   130 ALTSIAPKGLKAVQTMLCGTSANENAIKTAFIWYQAQRRGGLGPDALHLESCMNQQKPGTPNLSV 194

  Fly   199 LSFKGAFHGRTLGALSTTHSKYIHKLDVPSFDWPIASFPEYRYPLDENVAHNKKEDEKCLSEVQD 263
            :.|:||||||:|..||.|.||.|||:|:|:||||||.||.|:||||:|||:|||:|::||::|:.
Worm   195 MGFEGAFHGRSLCMLSVTRSKPIHKVDIPAFDWPIAKFPRYKYPLDQNVAYNKKQDQECLADVEA 259

  Fly   264 LIQQYASK-NPVAGIVVEPIQSEGGDNEASPEFFRSLQAICKKNGIALLIDEVQTGGGSTGKFWA 327
            .|.::..: |.||.|:|||||:||||:..||.||:.|:.|..|:||..::||||||||:||..||
Worm   260 KISEWKRRDNDVAAIIVEPIQAEGGDHYGSPAFFQGLRDITSKHGIVFIVDEVQTGGGATGDIWA 324

  Fly   328 HEHFELESPPDVVTFSKKLQLGGYFHNDDFIPNEPYRIFNTWMGDPGKVLLLEEVVKVIQEEKLL 392
            |:|:.|.||||:|||||||..||||:.:.....|.|||:|||||||.|:||||:.|:||:.:.|:
Worm   325 HDHWNLSSPPDMVTFSKKLLTGGYFYGEHLRVKEAYRIYNTWMGDPTKLLLLEKAVEVIKRDGLI 389

  Fly   393 ANVDVAGKVLKNGLLSLEKEFPHILNSTRGRGTFLAVNCTNTKVRDQIIGALKLHGIQTGGCGEI 457
            ......|...:..|..|:......|:..||||||.||:..:..:||:.:.....:|:..||||:.
Worm   390 EQSREVGAEFQKRLGELQASSGGKLDQARGRGTFAAVDFPSGSLRDKFVDLAISNGLHCGGCGDR 454

  Fly   458 SIRFRPALIFKEYHANIVLDRFRKVLQGI 486
            |:||||:|::.:.|.::..|...|.|:|:
Worm   455 SLRFRPSLVYTKKHLDLTFDLLDKTLKGL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabat	NP_001163479.1	GabT	27..484	CDD:223238	230/457 (50%)
Gabat	NP_001163479.1	AAT_I	27..483	CDD:302748	230/456 (50%)
gta-1	NP_501862.1	GabT	23..483	CDD:223238	231/460 (50%)
gta-1	NP_501862.1	AAT_I	24..480	CDD:302748	230/456 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157542
Domainoid	1	1.000	451	1.000	Domainoid score	I259
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H542
Inparanoid	1	1.050	483	1.000	Inparanoid score	I798
Isobase	1	0.950	-	0	Normalized mean entropy	S672
OMA	1	1.010	-	-		QHG55983
OrthoDB	1	1.010	-	-		D222188at33208
OrthoFinder	1	1.000	-	-		FOG0005369
OrthoInspector	1	1.000	-	-		oto17694
orthoMCL	1	0.900	-	-		OOG6_103520
Panther	1	1.100	-	-	LDO	PTHR43206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R468
SonicParanoid	1	1.000	-	-		X3808
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890