DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gabat and abat

DIOPT Version :9

Sequence 1:	NP_001163479.1	Gene:	Gabat / 40188	FlyBaseID:	FBgn0036927	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001121529.1	Gene:	abat / 100158654	XenbaseID:	XB-GENE-957494	Length:	500	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	267/484 - (55%)
Similarity:	353/484 - (72%)	Gaps:	10/484 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LTKQSLYRLSTKRYSTNVEPKE--------PVVKTKSIPGPKSIELKKQLDSVQATGTIQFFADY 65
            |.:.|...|...||.:....|:        |::||: :|||:|.||.|||.::|.:..:.||.:|
Frog    14 LQQNSRLLLPCVRYISQAAAKKNVDFEYDSPLMKTE-VPGPRSRELIKQLSTIQNSEAVHFFCNY 77

  Fly    66 EKSIGNYIYDVDGNILLDVYTQISSVPLGYNHPRLYKVFNNEQNLKTLINRPALGVFPGKEWPEK 130
            |:|.|||:.|||||.:||:|:||||:|:|||||.|.|:....|||.|.:||||||:.|.:.:.||
Frog    78 EESRGNYLVDVDGNRMLDLYSQISSIPIGYNHPALIKILQQPQNLSTFVNRPALGILPPENFTEK 142

  Fly   131 LHSVLLNIAPKGLNKITTMMCGSCSNENAYKSIFIWYQNKLRGNAPLTEQEKNSCMINIPPGAPK 195
            |...||::.||||.::.||.|||||||||:|.||:||:||.||:..:|::|.:|||||..||.|.
Frog   143 LEDSLLSVGPKGLRQVITMSCGSCSNENAFKLIFMWYRNKERGHTGVTKEELDSCMINQFPGCPD 207

  Fly   196 LSILSFKGAFHGRTLGALSTTHSKYIHKLDVPSFDWPIASFPEYRYPLDENVAHNKKEDEKCLSE 260
            .|||||.|.|||||:|.|:|||||.|||||:||||||||.||..:|||::.|..|:.|:.:||.|
Frog   208 YSILSFMGGFHGRTMGCLATTHSKAIHKLDIPSFDWPIAPFPRLKYPLEQFVKENQDEEARCLEE 272

  Fly   261 VQDLIQQY-ASKNPVAGIVVEPIQSEGGDNEASPEFFRSLQAICKKNGIALLIDEVQTGGGSTGK 324
            |:|||.:| ..|..||||||||||||||||.||.:|||.|:.|.:|:|.|.|:||||||||||||
Frog   273 VEDLIVKYRKKKKTVAGIVVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGK 337

  Fly   325 FWAHEHFELESPPDVVTFSKKLQLGGYFHNDDFIPNEPYRIFNTWMGDPGKVLLLEEVVKVIQEE 389
            ||||||:.::.|.|||:|||||..||:||.::|.||.||||||||:|||.|.|||.||:.||:.|
Frog   338 FWAHEHWGMDDPADVVSFSKKLMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVLNVIKRE 402

  Fly   390 KLLANVDVAGKVLKNGLLSLEKEFPHILNSTRGRGTFLAVNCTNTKVRDQIIGALKLHGIQTGGC 454
            .||:|...|||.|.:|||..:..:||:::..||||||.:::..:..:|:::|...:..||..|||
Frog   403 ALLSNAVQAGKALLDGLLDFQTRYPHLVSRARGRGTFCSIDTPSDAIRNKLILQARNKGIVLGGC 467

  Fly   455 GEISIRFRPALIFKEYHANIVLDRFRKVL 483
            |:.||||||.|:|||:||::.|:.|..:|
Frog   468 GDKSIRFRPTLVFKEHHAHLFLNIFNDIL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gabat	NP_001163479.1	GabT	27..484	CDD:223238	262/466 (56%)
Gabat	NP_001163479.1	AAT_I	27..483	CDD:302748	261/464 (56%)
abat	NP_001121529.1	AAT_I	34..496	CDD:388495	261/462 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	532	1.000	Domainoid score	I283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H542
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1092
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222188at33208
OrthoFinder	1	1.000	-	-		FOG0005369
OrthoInspector	1	1.000	-	-		oto102456
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R468
SonicParanoid	1	1.000	-	-		X3808
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090