DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7646 and GUCA1C

DIOPT Version :9

Sequence 1:	NP_001287124.1	Gene:	CG7646 / 40187	FlyBaseID:	FBgn0036926	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_005450.3	Gene:	GUCA1C / 9626	HGNCID:	4680	Length:	209	Species:	Homo sapiens

Alignment Length:	153	Identity:	54/153 - (35%)
Similarity:	90/153 - (58%)	Gaps:	5/153 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 WYKGFKQDCPNGRLTPAKFVDMYKMFFPSGNAEEFCDHVFRTFDMDKNGYIDFKEFLLAIDVTSS 96
            ||:.|..:.|:|..|..:|..:..:...:..|.:..|.|:.|||.:|:|::||.||:.|:::...
Human    22 WYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQ 86

  Fly    97 GTPEEKLKWAFRMYDVDGNGVIDIQEMTKIVQAIYDMLGACSSNRPADSAEERAKNIFAKMDENN 161
            ...|:||||.|::||.||||.||..|:..:..|:..:.|     :...|.||....:|.|:|.||
Human    87 EKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNG-----QQTLSPEEFINLVFHKIDINN 146

  Fly   162 DGQLTQDEFLKGCLQDEELSKML 184
            ||:||.:||:.|..:|::|.:::
Human   147 DGELTLEEFINGMAKDQDLLEIV 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7646	NP_001287124.1	FRQ1	18..178	CDD:227455	52/145 (36%)
GUCA1C	NP_005450.3	FRQ1	15..165	CDD:227455	53/147 (36%)
		EFh	56..118	CDD:238008	27/61 (44%)
		EFh	92..160	CDD:238008	31/72 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840