DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7646 and KCNIP4

DIOPT Version :9

Sequence 1:	NP_001287124.1	Gene:	CG7646 / 40187	FlyBaseID:	FBgn0036926	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_079497.2	Gene:	KCNIP4 / 80333	HGNCID:	30083	Length:	250	Species:	Homo sapiens

Alignment Length:	175	Identity:	62/175 - (35%)
Similarity:	107/175 - (61%)	Gaps:	5/175 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EDMEFLKTHTRYDEATIKEWYKGFKQDCPNGRLTPAKFVDMYKMFFPSGNAEEFCDHVFRTFDMD 77
            |.:|.|:..:::.:..::..|:|||.:||:|.:....|.::|..|||.|::..:...:|..||.|
Human    71 EALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTD 135

  Fly    78 KNGYIDFKEFLLAIDVTSSGTPEEKLKWAFRMYDVDGNGVIDIQEMTKIVQAIYDMLGACSSNRP 142
            .||.:.|::|:..:.:...||.:|||.|||.:||::.:|.|..:||..|::|||||:|.|:  .|
Human   136 HNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCT--YP 198

  Fly   143 A---DSAEERAKNIFAKMDENNDGQLTQDEFLKGCLQDEELSKML 184
            .   |:..:..:..|.|||:|.||.:|.|||::.|.:||.:.:.:
Human   199 VLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSM 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7646	NP_001287124.1	FRQ1	18..178	CDD:227455	58/162 (36%)
KCNIP4	NP_079497.2	KIS. /evidence=ECO:0000250	2..44
		FRQ1	80..239	CDD:227455	59/160 (37%)
		Interaction with KCND2. /evidence=ECO:0000250	237..250		1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740