DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7646 and KCNIP3

DIOPT Version :9

Sequence 1:	NP_001287124.1	Gene:	CG7646 / 40187	FlyBaseID:	FBgn0036926	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_038462.1	Gene:	KCNIP3 / 30818	HGNCID:	15523	Length:	256	Species:	Homo sapiens

Alignment Length:	171	Identity:	64/171 - (37%)
Similarity:	101/171 - (59%)	Gaps:	5/171 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EDMEFLKTHTRYDEATIKEWYKGFKQDCPNGRLTPAKFVDMYKMFFPSGNAEEFCDHVFRTFDMD 77
            |.::.|:..|::.:..::..|:|||.:||.|.:....|..:|..|||.|:|..:...:|..||.|
Human    77 EGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDAD 141

  Fly    78 KNGYIDFKEFLLAIDVTSSGTPEEKLKWAFRMYDVDGNGVIDIQEMTKIVQAIYDMLGACSSNRP 142
            .||.|.|::|::.:.:...||..|||||||.:||::.:|.|..:||..|:::||||:|  ....|
Human   142 GNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMG--RHTYP 204

  Fly   143 ---ADSAEERAKNIFAKMDENNDGQLTQDEFLKGCLQDEEL 180
               .|:..|..:..|.|||.|.||.:|.:|||:.|.:||.:
Human   205 ILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7646	NP_001287124.1	FRQ1	18..178	CDD:227455	61/162 (38%)
KCNIP3	NP_038462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		FRQ1	81..245	CDD:227455	63/165 (38%)
		EFh	130..192	CDD:238008	25/61 (41%)
		EFh	166..238	CDD:238008	32/73 (44%)
		Interaction with KCND2. /evidence=ECO:0000250	243..256		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740