DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nca and GUCA1C

DIOPT Version :9

Sequence 1:	NP_788543.1	Gene:	Nca / 40186	FlyBaseID:	FBgn0013303	Length:	190	Species:	Drosophila melanogaster
Sequence 2:	NP_005450.3	Gene:	GUCA1C / 9626	HGNCID:	4680	Length:	209	Species:	Homo sapiens

Alignment Length:	158	Identity:	59/158 - (37%)
Similarity:	95/158 - (60%)	Gaps:	6/158 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALS 90
            |...||:.|:.:.|||..::.|||.:.|.......|:|..:.|:.|||.|.||.:||.||:.|::
Human    18 ETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVN 82

  Fly    91 VTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTAIYKMVGSVMKMPEDESTPEKRTDKIFRQ 155
            :..:.|:||||||.|.:||.||||.|.:.|:|::..|:..:.|      :...:||:..:.:|.:
Human    83 LIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNG------QQTLSPEEFINLVFHK 141

  Fly   156 MDRNKDGKLSLEEFIEGAKSDPSIVRLL 183
            :|.|.||:|:|||||.|...|..::.::
Human   142 IDINNDGELTLEEFINGMAKDQDLLEIV 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nca	NP_788543.1	FRQ1	13..179	CDD:227455	59/152 (39%)
GUCA1C	NP_005450.3	FRQ1	15..165	CDD:227455	59/152 (39%)
		EFh	56..118	CDD:238008	29/61 (48%)
		EFh	92..160	CDD:238008	30/73 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910