DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nca and Ncs1

DIOPT Version :9

Sequence 1:	NP_788543.1	Gene:	Nca / 40186	FlyBaseID:	FBgn0013303	Length:	190	Species:	Drosophila melanogaster
Sequence 2:	NP_077342.1	Gene:	Ncs1 / 65153	RGDID:	68417	Length:	190	Species:	Rattus norvegicus

Alignment Length:	183	Identity:	116/183 - (63%)
Similarity:	149/183 - (81%)	Gaps:	0/183 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKQNSKLKPEVLEDLKQNTEFTDAEIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGDASKFA 65
            |||.||||||||:|:|.:.|.||:.|:|:|||||:||||||.|....|:|||..|||:||.:|||
  Rat     1 MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFA 65

  Fly    66 EHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTAIYK 130
            ..||..||.|.||.|:|.||:.||||||||.|::||:|||.:||||.:|||:|.|||:||.|||:
  Rat    66 TFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQ 130

  Fly   131 MVGSVMKMPEDESTPEKRTDKIFRQMDRNKDGKLSLEEFIEGAKSDPSIVRLL 183
            |||:.:::||:|:|||||.|:||..||:|.||||:|:||.||:|:|||||:.|
  Rat   131 MVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQAL 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nca	NP_788543.1	FRQ1	13..179	CDD:227455	101/165 (61%)
Ncs1	NP_077342.1	FRQ1	20..179	CDD:227455	99/158 (63%)
		Ancestral calcium site 1	36..47		7/10 (70%)
		Interaction with IL1RAPL1. /evidence=ECO:0000250\|UniProtKB:P62166	174..190		7/10 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53747
OrthoDB	1	1.010	-	-		D1369072at2759
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100764
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730