DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nca and GUCA1B

DIOPT Version :9

Sequence 1:	NP_788543.1	Gene:	Nca / 40186	FlyBaseID:	FBgn0013303	Length:	190	Species:	Drosophila melanogaster
Sequence 2:	NP_002089.4	Gene:	GUCA1B / 2979	HGNCID:	4679	Length:	200	Species:	Homo sapiens

Alignment Length:	198	Identity:	89/198 - (44%)
Similarity:	122/198 - (61%)	Gaps:	19/198 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKQNSKLKPEVLEDLKQNTEFTDAEIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGD---AS 62
            ||::.|      .|:.:...|...||:|||||.|:.:||||.|.:.|||:    ||...|   ||
Human     1 MGQEFS------WEEAEAAGEIDVAELQEWYKKFVMECPSGTLFMHEFKR----FFKVTDDEEAS 55

  Fly    63 KFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTA 127
            ::.|.:||.||.|||.||||.|::.||::..||.||.||||.|.:||.||||.|.|.|:|.||..
Human    56 QYVEGMFRAFDKNGDNTIDFLEYVAALNLVLRGTLEHKLKWTFKIYDKDGNGCIDRLELLNIVEG 120

  Fly   128 IYKMVGSVMKMPEDES----TPEKRTDKIFRQMDRNKDGKLSLEEFIEGAKSDPSIVRLLQCD-- 186
            ||::..:..:..:.|.    |||:..|:||..:|.|.||:|||.||:|||:.|..::::||.|
Human   121 IYQLKKACRRELQTEQGQLLTPEEVVDRIFLLVDENGDGQLSLNEFVEGARRDKWVMKMLQMDMN 185

  Fly   187 PQS 189
            |.|
Human   186 PSS 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nca	NP_788543.1	FRQ1	13..179	CDD:227455	81/172 (47%)
GUCA1B	NP_002089.4	FRQ1	20..174	CDD:227455	77/157 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D495747at33208
OrthoFinder	1	1.000	-	-		FOG0000038
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920