DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy7

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_445848.1	Gene:	Adcy7 / 84420	RGDID:	619966	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1325	Identity:	453/1325 - (34%)
Similarity:	622/1325 - (46%)	Gaps:	344/1325 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LYTRYRQRLRKS-LFRSGLLTSLLACV--VSIIIG--------------------------IVYG 105
            ||.:||...:.. |....||.::..|:  |||:..                          :||.
  Rat    21 LYEKYRLTSQHGPLLLLLLLVAVATCIALVSIVFSHEDLRRHQAVLGTAFFMLTLFVALYVLVYV 85

  Fly   106 QHLVQTMLLVLAAL------ISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAP 164
            :.|.|..|.|||.|      |.||:|    ....|.:.|.|.                   |..|
  Rat    86 ECLAQRWLRVLALLTWACLMILGSVL----MWDSLENEAYAW-------------------EQVP 127

  Fly   165 LPMYALFLCIHSMLPISWPVSVVLALFMTAIHIV--------YRIGTSPDYAPNLPMLFGEIVML 221
            ..::.:|: ::.:||:|...::.:.:..|..|::        ::...|.... .|.:|...:::|
  Rat   128 FFLFIVFV-VYVLLPLSTRAAIAVGVASTISHLLVFGAVTRAFKTSMSSTQL-GLQLLANAVILL 190

  Fly   222 ASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLK 286
            ........:...:.||:.:..:...:. |:.|.||..|:.|||.|||||:||:|:..:|.:|:.:
  Rat   191 GGNFTGAFHKHQLQDASRDLFIYTVKC-IQIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIER 254

  Fly   287 MADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQ 351
            :    :..|.:..|....||.|:|:||.||:||:||||.||.|:|..:..:||..||:|||:|||
  Rat   255 L----KEGGDRHYTPDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQ 315

  Fly   352 IAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTG 416
            ||:.|:|:||||||||||||||||:|.|.||.|||.|||.:.:||:.||||||:::.||:|||:|
  Rat   316 IAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSG 380

  Fly   417 NVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLA 481
            ||||||:||||||:||||.||:|||.||:.||.||||||:.||:.|...:|||.|.|..||.||.
  Rat   381 NVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLK 445

  Fly   482 DHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAP 546
            :..:.:||::.|:              .|..|.|             ||.            ::.
  Rat   446 EMNIRTYLVIDPR--------------SQQPPLP-------------SHH------------LSK 471

  Fly   547 PPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKE 611
            |..                  .|.|...||:.:....|....|                     .
  Rat   472 PKG------------------DATLKMRASVRVTRYLESWGAA---------------------R 497

  Fly   612 PKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPA 676
            |.|:..||        |||                |.||..|.|...|            .|.|
  Rat   498 PFAHLNHR--------ESV----------------SSSEIPIPNGRRQ------------KAIP- 525

  Fly   677 GGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRP 741
                   |....||:||                    |..:||                 ..:..
  Rat   526 -------LRRHRAPDRS--------------------ASPKGR-----------------LEDDC 546

  Fly   742 SSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTM 806
            ..:|...:|...:.||..:                           |..:|:.|||....|.|
  Rat   547 DDEMLSAIEGLSSTRPCCS---------------------------KSDDFHTFGPIFLEKGF-- 582

  Fly   807 WYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLG---SLLASFVSLAL-F 867
                   |..||..|....|:|..||.::|:.:.:|.|:|:. .:|.||   .|:|..:.|.| |
  Rat   583 -------EREYRLVPIPRARYDFACASLVFVCILLVHLLVMP-RMATLGLSFGLVACLLGLVLSF 639

  Fly   868 LYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVIN--YTVPDGVSKE 930
            .:.:..|......||.:  ...:.|.:...|||::.||.   :.|....::||  .|...| .::
  Rat   640 CFATEFSRCLPARSTLQ--AISESVETQPLLRLSLVVVT---VGSLLTVAIINMPLTFNPG-PEQ 698

  Fly   931 PSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAM 995
            |..|:|      |.:...:        .:.....:.|.:...|.:...|.|.|||....||.:.:
  Rat   699 PGDNET------SPLAARN--------RVGTPCELLPYYTCSCVLGFIACSVFLRMSLELKAMLL 749

  Fly   996 LVAVIAQVTVLGYSDLFEM---YNDANITH----------------------------------G 1023
            .||::|.:.:...|..:::   ..:.|.||                                  .
  Rat   750 TVALVAYLLLFNLSPCWQVSGNSTETNSTHRTRRLLSAEQSMNSHTLALGAQMTAPSPSSCLERD 814

  Fly  1024 LPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHV 1088
            |...|..:|:|....|:|  |.||.:|..|.|.|||.|.|.|.||.|||..:|::||||:|||||
  Rat   815 LKTMINFYLVLFYATLIL--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHV 877

  Fly  1089 ATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKP 1153
            |.||:..:.:.:.||:||.||.|||||:|::|.||.|.||||:||||||||||||.|||:|||||
  Rat   878 AAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKP 942

  Fly  1154 KFSGIEKIKTIASTYMCASGLR--PGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSIN 1216
            ||||:||||||.||||.|:||.  .|.|:       .|.:|...| :.:||||::||||.||.||
  Rat   943 KFSGVEKIKTIGSTYMAAAGLSVPSGHEN-------QDLERKHVH-IGVLVEFSMALMSKLDGIN 999

  Fly  1217 RESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTA 1281
            |.||..||||:|:||||||||||||:|||||||.|||||||||:|.|.:|::|.||.|..||...
  Rat  1000 RHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGL 1064

  Fly  1282 GYECECRGLTYVKGKGNLVTYFVKT 1306
            ||.||||||..|||||.|.||||.|
  Rat  1065 GYSCECRGLINVKGKGELRTYFVCT 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	59/261 (23%)
		CYCc	259..467	CDD:214485	122/207 (59%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	25/156 (16%)
		CYCc	1079..1283	CDD:214485	131/205 (64%)
		Guanylate_cyc	1101..1305	CDD:278633	136/205 (66%)
Adcy7	NP_445848.1	AC_N	<21..251	CDD:318454	58/255 (23%)
		Guanylate_cyc	272..422	CDD:306677	101/149 (68%)
		DUF1053	487..593	CDD:399378	40/243 (16%)
		Guanylate_cyc	891..1087	CDD:306677	135/203 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1717
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	730	1.000	Inparanoid score	I586
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840