Protein Alignment Ac76E and Adcy2

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_112269.2
• Gene: Adcy2 / 81636
• RGDID: 619965
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1327
• Identity: 448/1327 - (33%)
• Similarity: 651/1327 - (49%)
• Gaps: 359/1327 - (27%)

  Fly    76 QRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAAL---ISGSILTALQFPAVLSSP 137
            ||.|..|:.|....|....::..::.||.|..|  .:|.|..||   :...:...:..|..|
  Rat    31 QRSRDWLYESYYCMSQQHPLIVFLLLIVMGACL--ALLAVFFALGLEVEDHVAFLITVPTAL--- 90

  Fly   138 AAALAFAI-------------VTTFSL-----------------GTIAAITGDELAPLPMYALFL 172
              |:.|||             :..|||                 ||::|  .|:::    :.||:
  Rat    91 --AIFFAIFILVCIESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSA--WDQVS----FFLFI 147

  Fly   173 --CIHSMLPISWPVSVVLALFMTAIHI----VYRIGTSPDYAPNL-PMLFGEIVMLASASVSGLY 230
              .:::|||.:...:::.::..::.|.    || :..:|....:| ..:...:::....:::|.|
  Rat   148 IFVVYTMLPFNMRDAIIASILTSSSHTIVLSVY-LSATPGAKEHLFWQILANVIIFICGNLAGAY 211

  Fly   231 YRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAG 295
            ::.:.:.|..:|...|...|:.|:|||.|:.|||:||||::||:||.|:|..|:.::..  .:||
  Rat   212 HKHLMELALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQG--PKAG 274

  Fly   296 GQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLR 360
            ...:|:  .||.|:|:|||||:||:||||.||.|:|..:..:||..||:|||:|||||:||:|:|
  Rat   275 QMENTN--NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMR 337

  Fly   361 IKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGL 425
            |||||||||||||||||.|.||.|||.|||.|.:||:.||:|||::::||:|:|:|||||||:||
  Rat   338 IKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGL 402

  Fly   426 RKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLI 490
            :|||:||||.|||||||||:|||.|||||:..||:.|...::||:|:|..||.||..|.|::|.:
  Rat   403 QKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGEIRDPYLKQHLVKTYFV 467

  Fly   491 VPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKM 555
            :.||                                                         .|:.
  Rat   468 INPK---------------------------------------------------------GERR 475

  Fly   556 SPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRG 620
            ||..:
  Rat   476 SPQHL------------------------------------------------------------ 480

  Fly   621 SGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLT 685
                                                                             
  Rat   481 ----------------------------------------------------------------- 480

  Fly   686 VAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVE 750
                               |..|....||                       :.|.|.:||:|:|
  Rat   481 -------------------FRPRHTLDGA-----------------------KMRASVRMTRYLE 503

  Fly   751 CWGADRPFANI--AESKLVKN--IGLASIAMIESNL------LPPERKCFNFNF----------- 794
            .|||.:|||::  .:|...:|  |....:.|.:.|.      ...::|.|....
  Rat   504 SWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGI 568

  Fly   795 -----FGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALL 854
                 :....:::..::.:.|...|..|||.....|::.:.||.::||.:.:||::|:.....|.
  Rat   569 NAQKQWLKSEDIQRISLLFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQILVLPKTSILG 633

  Fly   855 GSLLASFVSLALFLYL---SNMSVPDVHASTT-----ERNGPGQVVASSRYLRLAMFVVVNILIS 911
            .|..|:|:||...|::   ..:......|||:     :.:|   ::|:..:.|:::.:|...:|.
  Rat   634 FSFGAAFLSLIFILFVCFAGQLLQCSKKASTSLMWLLKSSG---IIANRPWPRISLTIVTTAIIL 695

  Fly   912 SCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYA--IPIAPVFLYCCA 974
            :.|||::...:        .|...|:..:|.|:  .|.::.|.|. .|.:|  :...|.|:|.|.
  Rat   696 TMAVFNMFFLS--------NSEETTLPTANTSN--ANVSVPDNQA-SILHARNLFFLPYFIYSCI 749

  Fly   975 ISLAAISAFLRSGFILKLIAMLVAVIAQVTVL---------GYSD-LFE---MYNDANITHGLPL 1026
            :.|.:.|.|||..:.||::.|:||::...|:|         .||. ||:   ::.|        |
  Rat   750 LGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLDAYSQVLFQRPGIWKD--------L 806

  Fly  1027 EIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATH 1091
            :..|.:.|.:..:.|..|.||.||..|.|||||.|.|.|:||:|||..:|::||||:||||||.|
  Rat   807 KTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEH 871

  Fly  1092 FLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKF 1155
            ||... ::.||||:||.||.|||||||::||||.|:||||:||||||||||||.|||.||.||||
  Rat   872 FLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKF 936

  Fly  1156 SGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESF 1220
            ||:||||||.||||.|:||     ....|:..|.|...:..::..:||||.||:..||:||:.||
  Rat   937 SGVEKIKTIGSTYMAATGL-----SAIPSQEHAQEPERQYMHIGTMVEFAYALVGKLDAINKHSF 996

  Fly  1221 QRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYEC 1285
            ..|:||:|:||||||||||||||||||||.|||||||||||.||:.::|.||.|:.||.|.||.|
  Rat   997 NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTC 1061

  Fly  1286 ECRGLTYVKGKGNLVTYFVKTPFDGKL 1312
            .|||:..|||||:|.||||.|.....|
  Rat  1062 TCRGIINVKGKGDLKTYFVNTEMSRSL 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	175/433 (40%)
		Guanylate_cyc	310..469	CDD:425528	106/158 (67%)
		Guanylate_cyc	1101..1305	CDD:425528	133/203 (66%)
Adcy2	NP_112269.2	AcyC	54..474	CDD:441717	181/494 (37%)
		Guanylate_cyc	285..469	CDD:425528	118/183 (64%)
		Adcy_cons_dom	499..604	CDD:461877	21/104 (20%)
		Guanylate_cyc	882..1081	CDD:425528	133/203 (66%)