DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	466	Identity:	119/466 - (25%)
Similarity:	191/466 - (40%)	Gaps:	120/466 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAAL--AFAI-VTTFS 150
            |...:.::.|:.|:.|..|                  :.||:...|||.:..:  .|.: ||.|.
Zfish   458 TFKFSLMLDIVKGMDYLHH------------------SPLQYHGHLSSSSCVVDSRFVLKVTDFG 504

  Fly   151 LGTIAAI-TGDELAPLPMYALFLCIHSMLPISWPVS-----VVLALFMTAIHIVYRIGTSPDYAP 209
            |.::..: |.......|..||......:|..|.|.:     .|.:..:.|..:|||.|  |.|.|
Zfish   505 LNSVRRLDTEQSPGSDPWTALLWRAPELLRQSIPANGTQKGDVYSFAIIAQEVVYRRG--PFYIP 567

  Fly   210 NLPMLFGEIVMLASAS--------------VSGLYYRIMS----------DAAHNRTV------D 244
            |......|||....|.              |..|...::|          |.::.||.      .
Zfish   568 NSHFSPREIVERVRAGGCSPSRPYIDRAECVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPH 632

  Fly   245 GTRTGI--------------------EQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMAD 289
            |....|                    |:..:|:.|:::.|.||..::|..:|:::       :|.
Zfish   633 GVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQL-------IAG 690

  Fly   290 ACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQ 354
            ...||                :.:..|||.|:||..||.:|:|||...:|..||||:..||.|..
Zfish   691 KTVRA----------------ETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIID 739

  Fly   355 ENQCLRIKILGDCYYCVSGLPI-SRPQHATNCVNMGLQMIDAIR-----HVREATGINVDMRIGI 413
            .:...:::.:||.|..|||||| :...||.....|.|.::..:|     ||.|.   .:.:|||:
Zfish   740 YHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQ---QLRVRIGV 801

  Fly   414 HTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHI---TKQTLD-FLGDKFEVE----- 469
            |:|..:.||:||:..::.::.|.|..|:.|||.|:..::|:   ||..|| |...:.|:.
Zfish   802 HSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHI 866

  Fly   470 QGEGGNRDAYL 480
            :|:|..|..:|
Zfish   867 KGKGWVRTFWL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	52/258 (20%)
		CYCc	259..467	CDD:214485	68/217 (31%)
		Guanylate_cyc	311..469	CDD:278633	60/167 (36%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556
		PKc_like	355..628	CDD:328722	42/189 (22%)
		HNOBA	<641..687	CDD:311573	8/45 (18%)
		CYCc	666..850	CDD:214485	65/209 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900