DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	268	Identity:	77/268 - (28%)
Similarity:	130/268 - (48%)	Gaps:	47/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DYAPNLPMLFGEI-VMLASASVSG-------LYYRIMSDAAHNRTVDGTRTGIEQRVK-LECERE 261
            |.:|.|..:|..| ..|..||..|       :..::.:.|.|...|      :|:|.: |..|:.
Mouse   810 DESPELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEV------VEERTRELVAEKR 868

  Fly   262 QQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNF 326
            :.|:||.:::|:::..              |...|::         :..:...:|||.|:|||.|
Mouse   869 KVEKLLSTMLPSFVGE--------------QLIAGKS---------VEPEHFESVTIFFSDIVGF 910

  Fly   327 TPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI-SRPQHATNCVNMGL 390
            |.|.|..:...:||.||||:..||...|.:...:::.:||.|...||||| :..|||.....|.|
Mouse   911 TKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMAL 975

  Fly   391 QMIDA-----IRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAG 450
            .::..     |.|:.|.   .:.:|||:|||.|:.||:|:...::.::.|.|.:|:.|||..:..
Mouse   976 HLLSVTTHFQIGHMPEE---RLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPL 1037

  Fly   451 RVHITKQT 458
            |:|:::.|
Mouse  1038 RIHVSQST 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	20/91 (22%)
		CYCc	259..467	CDD:214485	62/206 (30%)
		Guanylate_cyc	311..469	CDD:278633	55/154 (36%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894	6/18 (33%)
		CYCc	865..1055	CDD:214485	62/207 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900