DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	87/340 - (25%)
Similarity:	147/340 - (43%)	Gaps:	102/340 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 IVMLASASVS--------GLYYRIMSD-AAHNRTVD--------GTRTGIEQRV----------- 254
            |:.|.|..|.        ||:   :|| ..|:.|.|        ..:.|:::|:
  Rat   417 ILFLGSPCVDKLDELIGRGLH---LSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTH 478

  Fly   255 -KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
             .||.|:::...||.|:.|..:|.::           .||            .::..::..:||:
  Rat   479 QALEEEKKKTVDLLYSIFPGDVAQQL-----------WQR------------QQVQARKFDDVTM 520

  Fly   319 LFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC-----LRIKILGDCYYCVSGLPISR 378
            ||:|||.||.:.:..|...::..||:|:.|||     :||     .:::.:||.|...|||....
  Rat   521 LFSDIVGFTAICAQCTPMQVISMLNELYTRFD-----HQCGFLDIYKVETIGDAYCVASGLHRKS 580

  Fly   379 PQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHM 443
            ..||.....|.|:|::....|....|..:.||||||:|:||.||:|:|..::.::.::||||:..
  Rat   581 LCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKF 645

  Fly   444 ESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECI 508
            |||....|::|:..|                             |.::..:.::|: :||..|.:
  Rat   646 ESGSHPRRINISPTT-----------------------------YQLLKREDSFTF-IPRSREEL 680

  Fly   509 EQNDPSPTTEETKEI 523
            ..|.|       |||
  Rat   681 PDNFP-------KEI 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	21/99 (21%)
		CYCc	259..467	CDD:214485	62/212 (29%)
		Guanylate_cyc	311..469	CDD:278633	54/162 (33%)
		BASP1	510..667	CDD:283191	5/14 (36%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002
		HNOBA	314..501	CDD:285003	20/86 (23%)
		CYCc	483..672	CDD:214485	63/245 (26%)
		Guanylate_cyc	512..696	CDD:278633	64/219 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810