Protein Alignment Ac76E and Adcy5

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_072122.2
• Gene: Adcy5 / 64532
• RGDID: 71014
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1384
• Identity: 431/1384 - (31%)
• Similarity: 615/1384 - (44%)
• Gaps: 384/1384 - (27%)

  Fly     6 AETAKTGNGTNATANLIVKADGNATQPKAMTS-SAARMNDALSASLADLSEQENGTTAEDIHLND 69
            ||..:.|.||      :...||:.....::.| |......:|.|....|.:...........|..
  Rat   171 AEELEPGTGT------VEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLER 229

  Fly    70 LYTRYRQRLRKSLFRSGLLTSLLACVVSII-------IGIVYGQHLVQTMLLVLAALISGSILTA 127
            ||.||..||.:|.....:...:|.|:|.:.       :.:||        |.||||.: |.||
  Rat   230 LYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVY--------LAVLAAAV-GVIL-- 283

  Fly   128 LQFPAVLSSPAA------ALA-FAIVTTFSLGTIAAITGDELAPLPMYA---------LFLCIHS 176
              ..|||.:.||      .|| :|::.......:..:    |.|.|..|         ....|::
  Rat   284 --IMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGL----LLPQPRSASEGIWWTVFFIYTIYT 342

  Fly   177 MLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNR 241
            :||:....:|:..:.::|:|:...:.|:......|..|...:::.:..::.|:.....::.:..:
  Rat   343 LLPVRMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQ 407

  Fly   242 TVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFH 306
            ....||..|:.|:..:.|.:|||:|||||:|.::|.|:|..|..|..|             ..||
  Rat   408 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQED-------------MMFH 459

  Fly   307 ELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCV 371
            ::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||||||||||||||
  Rat   460 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCV 524

  Fly   372 SGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDD 436
            ||||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:|
  Rat   525 SGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSND 589

  Fly   437 VTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSV 501
            ||||||||:||.|||:||||.||::|...:|||.|.||.|:|||.:|.:|::||
  Rat   590 VTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLI----------- 643

  Fly   502 PRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAP 566
               :.|         |::.||                              ||.....:|.|.
  Rat   644 ---LRC---------TQKRKE------------------------------EKAMIAKMNRQR-- 664

  Fly   567 LHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVA 631
                                         |..:.|         .|...|..|...:......|:
  Rat   665 -----------------------------TNSIGH---------NPPHWGAERPFYNHLGGNQVS 691

  Fly   632 KSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRK 696
            |.          :...|.|.. .:..|| :|:||..                    |..|...|.
  Rat   692 KE----------MKRMGFEDP-KDKNAQ-ESANPED--------------------EVDEFLGRA 724

  Fly   697 LSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANI 761
            :..:.:    ||.||.                      ||
  Rat   725 IDARSI----DRLRSE----------------------HV------------------------- 738

  Fly   762 AESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFR 826
                                                    :.|.:.:|....|..|..|.|..|.
  Rat   739 ----------------------------------------RKFLLTFREPDLEKKYSKQVDDRFG 763

  Fly   827 FDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLS-------------------- 871
            ..:.||.::||.:..||:.::..:|.:|...|:.|:.|||.:::|
  Rat   764 AYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKI 828

  Fly   872 -----NMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNIL-------------ISSCAVF-S 917
                 |.::..|...|        :|..|.::.:.|....|::             :::|.|. |
  Rat   829 VRSKKNSTLVGVFTIT--------LVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMES 885

  Fly   918 VINYTVPD--GVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAI 980
            ..||::.|  |....|.||     .||...|..|.|                       :||.|.
  Rat   886 AFNYSLGDEQGFCGSPQSN-----CNFPEYFTYSVL-----------------------LSLLAC 922

  Fly   981 SAFLRSGFILKLIAM--------LVAVIAQVTVLGYSDLFEMYNDANITHG-----------LPL 1026
            |.||:...|.||:.|        |:..:..||:...:||....|..:.::.           :.|
  Rat   923 SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVAL 987

  Fly  1027 EIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATH 1091
            ::...:::.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|
  Rat   988 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAH 1052

  Fly  1092 FLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKF 1155
            ||..| |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:|
  Rat  1053 FLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRF 1117

  Fly  1156 SGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESF 1220
            ..:||||||.||||.||||.....|          |..:.| :..|.:||:.||..:..||..||
  Rat  1118 RQLEKIKTIGSTYMAASGLNDSTYD----------KAGKTH-IKALADFAMKLMDQMKYINEHSF 1171

  Fly  1221 QRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYEC 1285
            ..|:::||||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|....|:.
  Rat  1172 NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL 1236

  Fly  1286 ECRGLTYVKGKGNLVTYFV 1304
            ||||:..|||||.::|||:
  Rat  1237 ECRGVVKVKGKGEMMTYFL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	172/420 (41%)
		Guanylate_cyc	310..469	CDD:425528	109/158 (69%)
		Guanylate_cyc	1101..1305	CDD:425528	110/204 (54%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	75/323 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..196		7/30 (23%)
		Guanylate_cyc	461..644	CDD:425528	122/196 (62%)
		Adcy_cons_dom	669..762	CDD:461877	28/224 (13%)
		Guanylate_cyc	1063..1257	CDD:425528	110/204 (54%)