DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac76E and Adcy5

DIOPT Version :9

Sequence 1:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_072122.2 Gene:Adcy5 / 64532 RGDID:71014 Length:1262 Species:Rattus norvegicus


Alignment Length:1384 Identity:431/1384 - (31%)
Similarity:615/1384 - (44%) Gaps:384/1384 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AETAKTGNGTNATANLIVKADGNATQPKAMTS-SAARMNDALSASLADLSEQENGTTAEDIHLND 69
            ||..:.|.||      :...||:.....::.| |......:|.|....|.:...........|..
  Rat   171 AEELEPGTGT------VEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLER 229

  Fly    70 LYTRYRQRLRKSLFRSGLLTSLLACVVSII-------IGIVYGQHLVQTMLLVLAALISGSILTA 127
            ||.||..||.:|.....:...:|.|:|.:.       :.:||        |.||||.: |.||  
  Rat   230 LYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVY--------LAVLAAAV-GVIL-- 283

  Fly   128 LQFPAVLSSPAA------ALA-FAIVTTFSLGTIAAITGDELAPLPMYA---------LFLCIHS 176
              ..|||.:.||      .|| :|::.......:..:    |.|.|..|         ....|::
  Rat   284 --IMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGL----LLPQPRSASEGIWWTVFFIYTIYT 342

  Fly   177 MLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNR 241
            :||:....:|:..:.::|:|:...:.|:......|..|...:::.:..::.|:.....::.:..:
  Rat   343 LLPVRMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQ 407

  Fly   242 TVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFH 306
            ....||..|:.|:..:.|.:|||:|||||:|.::|.|:|..|..|..|             ..||
  Rat   408 AFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQED-------------MMFH 459

  Fly   307 ELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCV 371
            ::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||||||||||||||
  Rat   460 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCV 524

  Fly   372 SGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDD 436
            ||||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:|
  Rat   525 SGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSND 589

  Fly   437 VTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSV 501
            ||||||||:||.|||:||||.||::|...:|||.|.||.|:|||.:|.:|::||           
  Rat   590 VTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLI----------- 643

  Fly   502 PRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAP 566
               :.|         |::.||                              ||.....:|.|.  
  Rat   644 ---LRC---------TQKRKE------------------------------EKAMIAKMNRQR-- 664

  Fly   567 LHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVA 631
                                         |..:.|         .|...|..|...:......|:
  Rat   665 -----------------------------TNSIGH---------NPPHWGAERPFYNHLGGNQVS 691

  Fly   632 KSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRK 696
            |.          :...|.|.. .:..|| :|:||..                    |..|...|.
  Rat   692 KE----------MKRMGFEDP-KDKNAQ-ESANPED--------------------EVDEFLGRA 724

  Fly   697 LSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANI 761
            :..:.:    ||.||.                      ||                         
  Rat   725 IDARSI----DRLRSE----------------------HV------------------------- 738

  Fly   762 AESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFR 826
                                                    :.|.:.:|....|..|..|.|..|.
  Rat   739 ----------------------------------------RKFLLTFREPDLEKKYSKQVDDRFG 763

  Fly   827 FDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLS-------------------- 871
            ..:.||.::||.:..||:.::..:|.:|...|:.|:.|||.:::|                    
  Rat   764 AYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKI 828

  Fly   872 -----NMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNIL-------------ISSCAVF-S 917
                 |.::..|...|        :|..|.::.:.|....|::             :::|.|. |
  Rat   829 VRSKKNSTLVGVFTIT--------LVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMES 885

  Fly   918 VINYTVPD--GVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAI 980
            ..||::.|  |....|.||     .||...|..|.|                       :||.|.
  Rat   886 AFNYSLGDEQGFCGSPQSN-----CNFPEYFTYSVL-----------------------LSLLAC 922

  Fly   981 SAFLRSGFILKLIAM--------LVAVIAQVTVLGYSDLFEMYNDANITHG-----------LPL 1026
            |.||:...|.||:.|        |:..:..||:...:||....|..:.::.           :.|
  Rat   923 SVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVAL 987

  Fly  1027 EIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATH 1091
            ::...:::.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|
  Rat   988 KVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAH 1052

  Fly  1092 FLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKF 1155
            ||..| |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:|
  Rat  1053 FLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRF 1117

  Fly  1156 SGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESF 1220
            ..:||||||.||||.||||.....|          |..:.| :..|.:||:.||..:..||..||
  Rat  1118 RQLEKIKTIGSTYMAASGLNDSTYD----------KAGKTH-IKALADFAMKLMDQMKYINEHSF 1171

  Fly  1221 QRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYEC 1285
            ..|:::||||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|....|:.
  Rat  1172 NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL 1236

  Fly  1286 ECRGLTYVKGKGNLVTYFV 1304
            ||||:..|||||.::|||:
  Rat  1237 ECRGVVKVKGKGEMMTYFL 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 62/244 (25%)
CYCc 259..467 CDD:214485 126/207 (61%)
Guanylate_cyc 311..469 CDD:278633 109/157 (69%)
BASP1 510..667 CDD:283191 21/156 (13%)
CYCc 1079..1283 CDD:214485 111/204 (54%)
Guanylate_cyc 1101..1305 CDD:278633 110/204 (54%)
Adcy5NP_072122.2 AC_N 1..459 CDD:318454 75/323 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..196 7/30 (23%)
Guanylate_cyc 461..634 CDD:306677 117/172 (68%)
DUF1053 669..761 CDD:399378 28/223 (13%)
Guanylate_cyc 1063..1257 CDD:306677 110/204 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.810

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