Protein Alignment Ac76E and Adcy3

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_570135.2
• Gene: Adcy3 / 64508
• RGDID: 71009
• Length: 1144
• Species: Rattus norvegicus
• Alignment Length: 1311
• Identity: 386/1311 - (29%)
• Similarity: 587/1311 - (44%)
• Gaps: 324/1311 - (24%)

  Fly    67 LNDLYTRYRQRLR-KSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQF 130
            |.:||..|.:|.| ::|....:..:|..|.|.::..:|:....:..:::....|:...||..|..
  Rat    62 LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCK 126

  Fly   131 PAVLSSPAAA-----LAFAIVT---------TFSLGTIAAITGDELAPLPMYALFLCIHSMLPIS 181
            ..:|....:.     |.:.::|         .||....|:.|....| ..:::.|:    .||:|
  Rat   127 KGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFSRAHAASDTVGWQA-FFVFSFFI----TLPLS 186

  Fly   182 WPVSVVLALFMTAIHIVYRIGTS-----PDYAPNLPML---FGEIVMLASASVSGLYYRIMSDAA 238
            ....|::::....:|.:. :|.:     .|....:.:|   ...:.:...|.:.|:....|:|..
  Rat   187 LSPIVIISVVSCVVHTLV-LGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRK 250

  Fly   239 HNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLK--MADACQRAGGQASTS 301
            |.:.....|..:|.::.||.:.:|||.|:||::|.::|.|     |||  ..|..|:       .
  Rat   251 HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADE-----MLKDMKKDESQK-------D 303

  Fly   302 ATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGD 366
            ..:|:.:::.||.||:|||||||.||.|||:.:|.:|||.||:||.|||::|.:...||||||||
  Rat   304 QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 368

  Fly   367 CYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFD 431
            ||||:.|||..|..||...:.|||.|::||.:|||.|...||||:|:|||.||.||||.::||:|
  Rat   369 CYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   432 VWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPA 496
            |||.|||:||.||:||:.|||||::.|:|.|..:|:||.|:||:|..||.:..:|:|||:..||
  Rat   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKP- 497

  Fly   497 YTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
                                     |:|:|.|:                             .:|
  Rat   498 -------------------------EVKKTAQN-----------------------------GLN 508

  Fly   562 SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAA 626
            ....|..||.:..:|.::.|                           .|||..:....||....|
  Rat   509 GSALPNGAPASKPSSPALIE---------------------------TKEPNGSAHASGSTSEEA 546

  Fly   627 SESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPE 691
            .|.                             :||:.||:...|
  Rat   547 EEQ-----------------------------EAQADNPSFPNP--------------------- 561

  Fly   692 RSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADR 756
              ||:|.:|.|   |||                                       .|:....:.
  Rat   562 --RRRLRLQDL---ADR---------------------------------------VVDASEDEH 582

  Fly   757 PFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQP 821
            ....:....|::.         ||..:..:|..|            ..||.:.:...|..|..:.
  Rat   583 ELNQLLNEALLER---------ESAQVVKKRNTF------------LLTMRFMDPEMETRYSVEK 626

  Fly   822 DTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERN 886
            :........|:.|:....|:|::::   :..|:.:.:...|...|.|.|:..|:    |:...|.
  Rat   627 EKQSGAAFSCSCVVLFCTAMVEILI---DPWLMTNYVTFVVGEVLLLILTICSM----AAIFPRA 684

  Fly   887 GPGQVVASSRYL-----------RLAMFVVV--NIL-ISSCAVFSVINYTVPDGVSKEPSSNQTI 937
            .|.::||.|.::           .||:|::|  |:: :.||..:.:..|.|..|:
  Rat   685 FPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNVTTGI---------- 739

  Fly   938 LESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFL-YCCAISLAAISAFLRSGFILKLIAMLV--AV 999
                                |:|......|.:. |...:||.|....::...::||..||:  ..
  Rat   740 --------------------ELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGA 784

  Fly  1000 IAQVTVLGYSDLFEMYNDANI-----------------THGL----------PLEIKGFLLLLVI 1037
            :..:.:..:..:|:.|:....                 |.||          |.:....:::.|:
  Rat   785 VTAINLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVM 849

  Fly  1038 ILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFL-HLERSTEL 1101
            :|..:...|..|.:|||.||||.::..::|.|..||..|:.|:.|:||.|||.||| ..:|..||
  Rat   850 MLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEEL 914

  Fly  1102 YHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIAS 1166
            |.:||..:.|||||:||:.:||.|..:|..|:||||.|||||.|||.||..|||..|.|||||.|
  Rat   915 YSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGS 979

  Fly  1167 TYMCASGLRPGKEDGATSRSFADEKRTEE--HNVVILVEFAIALMSILDSINRESFQRFRLRIGL 1229
            |||.|||:.|.......:.|..:||..:|  .::..|.:||:|:...|.:||.:||..|.||||:
  Rat   980 TYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGM 1044

  Fly  1230 NHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVK 1294
            |.|.|:||||||:||.||||.|||||||||:|.||||.:|..|.|..||...|:....||..:||
  Rat  1045 NKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVK 1109

  Fly  1295 GKGNLVTYFVK 1305
            |||.|:|:|:|
  Rat  1110 GKGELLTFFLK 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	148/422 (35%)
		Guanylate_cyc	310..469	CDD:425528	94/158 (59%)
		Guanylate_cyc	1101..1305	CDD:425528	110/205 (54%)
Adcy3	NP_570135.2	AcyC	105..499	CDD:441717	153/437 (35%)
		Guanylate_cyc	310..494	CDD:425528	106/183 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..563		19/166 (11%)
		Guanylate_cyc	914..1121	CDD:425528	111/207 (54%)