DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	190/983 - (19%)
Similarity:	315/983 - (32%)	Gaps:	301/983 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 GLPISRPQHATNCVN--------------MGLQMIDA--IRHVREATGINVDMRIGIHTGN---- 417
            |||.|....|:.|..              :.||..|.  :||..:...::|..|   |..:
  Rat   130 GLPASCSASASLCTRSLDRKTLLQKHRQLLQLQPSDRDWVRHQLQRGCVHVFDR---HMASSYLR 191

  Fly   418 -VLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLA 481
             |||.:             |.|.|.      ||.|:               ::.|..|.....:.
  Rat   192 PVLCTL-------------DTTAAE------VAARL---------------LQLGHKGGGVVKVL 222

  Fly   482 DHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDV--------ADV 538
            .|        .|.||   :.|..      :|.:|.||..::::....|.....|        ||:
  Rat   223 GH--------GPPPA---AAPAA------SDQTPATELGRDVEPPPSSSTVGAVRGPARAPPADL 270

  Fly   539 LLP----------VTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSE--------- 584
            .||          |..||..:...|..:....:...||  .|.:...|.|:...:|
  Rat   271 PLPGGAWTRCAPRVNPAPSDSSPGELFAGGPCSPSRAP--RPASDTESFSLSPSAESVSDRLDPY 333

  Fly   585 ----------EEDEADEATAVTEP----------LMHRDQDGKNDK--EPKANGGHRGS----GD 623
                      ||.|||.||.:|.|          ...|....|...  :|||..|..|:    |:
  Rat   334 SSGGGSSSSSEELEADPATVLTGPSGPPHHPVRSSQPRPPSPKTSALLQPKAPTGVDGTGLVVGE 398

  Fly   624 SAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAE 688
            ....:....:||..:|             :...|...::....|..|:......|..:..|...|
  Rat   399 GPGDDKAVAAAAPGVP-------------LWTPGRIRETVQKTSSPPSLYVQLHGETTRRLEADE 450

  Fly   689 APERSRRKLSVQGLMSFAD--RRRSSG---------AFIEGRKLSIHSGESFRSHAGHVTRNRPS 742
            .|.:.:.....|  :.|.:  |.:..|         .|..|:..|..|.|..:....:..|   .
  Rat   451 KPLQIQNDYLFQ--LGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLSGMYNVR---K 510

  Fly   743 SKMTKYVECW--------GADRPFANIAESKLVKNIGLASI-AMIESNLLPPERKCFNFNFFGPP 798
            .||...|..|        |.....:::.:|...|...|..| ..:|.  :...:.|..|:..||.
  Rat   511 GKMQLPVNRWTRRQVILCGTCLIVSSVKDSSSGKMHVLPLIGGKVEE--VKKHQHCLAFSSSGPQ 573

  Fly   799 TE--------LKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFV------LFLSLAVVQLIVIEL 849
            ::        ...:..|.|...:.|..|..     ..||.|..:      ||.|..:..|
  Rat   574 SQTYYICFDTFTEYLRWLRQVSKVASQRIS-----SVDLSCCSLEHLPANLFYSQDLTHL----- 628

  Fly   850 NLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCA 914
                  :|..:|:.       .|.|:|       ...|.|::   .|:.:|..   :|:..:...
  Rat   629 ------NLKQNFLR-------QNPSLP-------AARGLGEL---QRFTKLKS---LNLSNNHLG 667

  Fly   915 VFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAA 979
            .|       |..|...|    |:.|.|.|   .|:..|          :|.|       ..::..
  Rat   668 AF-------PSAVCSIP----TLAELNVS---CNALRE----------VPAA-------VGAMQN 701

  Fly   980 ISAFLRSGFILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTL 1044
            :..||..|..|:.:...:..:.|::.||.|  |..:.|      :|..::....:..:.:..:.:
  Rat   702 LQTFLLDGNFLQSLPAELENMHQLSYLGLS--FNEFTD------IPEVLEKLTAVDKLCMAGNCM 758

  Fly  1045 D-------RQGEYVARTDFLWKAKLKVEQEEVETMRGINKI-LLENILPAHVATHF-----LHLE 1096
            :       |:..::...|.......|:..:||:.::.:.:: |.:|.|....|..|     ||.|
  Rat   759 ETLRLQALRRMPHIKHVDLRLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVLHCE 823

  Fly  1097 RS------------TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKL 1149
            |:            ..||..|...|.:....:|||..:   .||::   .||..:.|.:|:..||
  Rat   824 RNQLVTLNICGYFLKALYASSNELVQLDVYPVPNYLSY---MDVSR---NCLESVPEWVCESRKL 882

  Fly  1150 LLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVIL-------VEFAIA 1207
            .:..  .|..:|..:.:...|.|.||  |.....:|.....:|.|..:|.:|       :|....
  Rat   883 EVLD--IGHNQICELPARLFCNSSLR--KLLAGHNRLARLPERLERTSVEVLDVQHNQIIELPPN 943

  Fly  1208 LMSILDSI 1215
            |:...||:
  Rat   944 LLMKADSL 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485	23/114 (20%)
		Guanylate_cyc	311..469	CDD:278633	23/116 (20%)
		BASP1	510..667	CDD:283191	41/209 (20%)
		CYCc	1079..1283	CDD:214485	40/161 (25%)
		Guanylate_cyc	1101..1305	CDD:278633	31/122 (25%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700	14/84 (17%)
		PHA03247	<237..443	CDD:223021	43/220 (20%)
		RA_PHLPP1	<424..491	CDD:340760	12/68 (18%)
		PH_PHLPP-like	498..594	CDD:270131	18/100 (18%)
		PLN00113	602..>1109	CDD:215061	85/435 (20%)
		leucine-rich repeat	604..624	CDD:275380	6/19 (32%)
		leucine-rich repeat	625..655	CDD:275380	9/57 (16%)
		leucine-rich repeat	679..701	CDD:275380	7/41 (17%)
		leucine-rich repeat	702..724	CDD:275380	4/21 (19%)
		leucine-rich repeat	725..771	CDD:275380	7/53 (13%)
		leucine-rich repeat	772..795	CDD:275380	4/22 (18%)
		leucine-rich repeat	796..816	CDD:275380	5/19 (26%)
		leucine-rich repeat	817..858	CDD:275380	9/40 (23%)
		leucine-rich repeat	859..881	CDD:275380	6/27 (22%)
		leucine-rich repeat	882..904	CDD:275380	4/23 (17%)
		leucine-rich repeat	905..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..950	CDD:275380	4/22 (18%)
		leucine-rich repeat	951..974	CDD:275380	0/1 (0%)
		leucine-rich repeat	977..1000	CDD:275380
		leucine-rich repeat	1001..1024	CDD:275380
		leucine-rich repeat	1067..1112	CDD:275380
		PP2Cc	1151..1403	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900