DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and CG34357

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	692	Identity:	152/692 - (21%)
Similarity:	272/692 - (39%)	Gaps:	173/692 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 AIHIVYRI-GTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRT--------- 248
            ||:|:.:. ...||..|:...::....||                .|.|.|:...|
  Fly  1010 AINIMRQCWAEQPDMRPDFNSVYERFKML----------------NHGRKVNFVDTMFQMLEKYS 1058

  Fly   249 -GIEQRVK-----LECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHE 307
             .:|:.::     |:.||::.||||..::|:.:|.::|..:                       .
  Fly  1059 NNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGL-----------------------A 1100

  Fly   308 LHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVS 372
            :..:..::|||.|:|||.||.:::..:...:|..||||:..||.........:::.:||.|..||
  Fly  1101 VDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGDAYMVVS 1165

  Fly   373 GLPISRPQHATNCVNMGLQMI--DAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSD 435
            |||:..|.||.....|.|.::  ....:|:...|:.:.:|||:|||....||:||...::.::.|
  Fly  1166 GLPVKIPDHAEQIATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGD 1230

  Fly   436 DVTLANHMESGGVAGRVHITKQTLDFLGDK--FEVE-------QGEGGNRDAYLADHK-VESYLI 490
            .|..|:.|||.|.:.|:|::::|.|.|..:  :.:|       :|:|.....:|...| .:..|.
  Fly  1231 TVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKKGFDKPLP 1295

  Fly   491 VPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHE-----ATDVADVLLPVTVAPPPAI 550
            .||....::.:.   |.:.:|..:...:..|....|:.|..     |.:..:|.:.:|   ||..
  Fly  1296 APPPIGESHGLD---ESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEIT---PPTN 1354

  Fly   551 VD------------------EKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTE 597
            .|                  ..:||.:....|.|.....:|.:..| ::|||         ...|
  Fly  1355 ADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSSTSPQS-RKLSE---------LTPE 1409

  Fly   598 PLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISN------- 655
            .|::   ....::.|.:.||    ..|...:.:.:...||.|.:....:|.|||.::.
  Fly  1410 NLLN---PNSFNRLPSSTGG----SSSRLYKKIEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYL 1467

  Fly   656 --------SGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSV------------- 699
                    .|.||.....||:. .:.:..||.||...:...:....||:.|:
  Fly  1468 YGSVAGGAGGGQAGGGACASIA-LSGSGCGGGASRFDSKPGSSRLLRRQFSLDRDDQQAKGEQQH 1531

  Fly   700 ----------QGLMSFADRRRSSGAFIEGRKLSI---HSGESFRSHAGHVTRN--RPSSKMTKYV 749
                      .||:.      ..|..::...|.|   |  ::.||..|.:||:  :.|:.:|:.:
  Fly  1532 HQHSLQANTYSGLVG------GCGGGVKSSMLDIPLLH--DTTRSPKGTLTRSHKQNSASITQDL 1588

  Fly   750 ECWGADR----PFANIAESKLVKNIGLASIAMIE--SNLLPP 785
            |  ..:.    |.::...|.|..|:..:..:.:|  |..|||
  Fly  1589 E--KIEEIPLSPASSQHHSSLDSNLNRSPPSTLEAQSPPLPP 1628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	23/110 (21%)
		CYCc	259..467	CDD:214485	62/211 (29%)
		Guanylate_cyc	311..469	CDD:278633	53/161 (33%)
		BASP1	510..667	CDD:283191	35/194 (18%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	8/46 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	62/214 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810