DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac76E and gucy2ca

DIOPT Version :9

Sequence 1:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster
Sequence 2:XP_009297342.1 Gene:gucy2ca / 572052 ZFINID:ZDB-GENE-091118-67 Length:1025 Species:Danio rerio


Alignment Length:1358 Identity:241/1358 - (17%)
Similarity:439/1358 - (32%) Gaps:505/1358 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 TNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAE--DIHLNDLY-----T 72
            ::.|.|:::..|.|:..      |...:.|.:..::.|   |.|...||  |.|:..|:     |
Zfish    28 SSVTLNVVLLEDENSPW------SLKFVKDVVETAVED---QNNKNHAEGLDFHIKVLFSGFNTT 83

  Fly    73 RYRQR-----------LRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILT 126
            .||:|           :.|||..:    |.|.||:                              
Zfish    84 HYRRRGCGSSTCEAVEILKSLHNN----SELGCVM------------------------------ 114

  Fly   127 ALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVLALF 191
                                               |.|...||.|..:...:.::..:.::.|  
Zfish   115 -----------------------------------LGPSCTYATFQLVDQEVGLTLTIPIISA-- 142

  Fly   192 MTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKL 256
                   ...|.|.||...|..|     :..:..::..::...     :.:|...:...:.....
Zfish   143 -------GSFGLSCDYKQKLTRL-----LPPARKIAEFFFHFW-----HTSVKNLKPAWKTAYVY 190

  Fly   257 ECEREQQEQL----LLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVT 317
            :.:...:|..    .|....|..::.:.|.::        |:..:.||:..|     ..||:|:.
Zfish   191 KKDNYTEECFWYINALEAPSALFSSNISREML--------RSESELSTALKR-----KDRHSNII 242

  Fly   318 ILFA---DIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRP 379
            ::..   ||  :|...::...|.:|..|.||:         |:..|..             .|.|
Zfish   243 VMCGTPDDI--YTIKKNNTVPSQVVFILIDLY---------NEGYRTN-------------ESSP 283

  Fly   380 QHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 444
            .|..|.:.:.:.   :.|:               ::.|             .||.::.|::    
Zfish   284 AHMRNVLVLTMH---SFRN---------------YSSN-------------SVWRNNTTVS---- 313

  Fly   445 SGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIE 509
                             :|..::::  ..|:||..|:        :|....:|.|   |.:...:
Zfish   314 -----------------IGGYYKLD--SSGDRDLNLS--------VVYTTGSYKY---RTLFSFD 348

  Fly   510 QNDPSPTTEETKEIKET------DQS------HEATDVADVL-----LPVTVAPPPAIV------ 551
                  |::...::|::      |:|      |...::.:::     |.|.:|...|.:      
Zfish   349 ------TSQNRTKVKDSSPDLPWDRSQLPRDKHTGMEIQEIMMIVLGLSVVLATVIAFILYRQNR 407

  Fly   552 ----DEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEP 612
                |:|......:|...||.....:..|::|    :|:.:.|.::.:        :.|:.||:|
Zfish   408 RVRFDQKKWSHISSSLITPLDDKERNYISLTI----DEDKKGDNSSLI--------RKGRYDKKP 460

  Fly   613 KANGGHRGS-GDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPA 676
            ......|.: |:....:.:..:|.|.:...:|....|                            
Zfish   461 VILKELRNTDGNFTDDQRIELNALLRIDYYNLTKFYG---------------------------- 497

  Fly   677 GGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRP 741
                    ||       |....|.|:..|.:  |.|..::...|:| :...||......::....
Zfish   498 --------TV-------RFDCGVFGVFEFCE--RGSLRYVLDDKIS-YPDASFMDLEFRISVMYD 544

  Fly   742 SSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKP-FT 805
            .:|...|:..                .|:|:.. .:..:|.:...|.......||..|.|.| ..
Zfish   545 IAKGMSYLHS----------------SNVGVHG-RLKSTNCVVDNRMVVKITDFGCNTILSPGKD 592

  Fly   806 MWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYL 870
            :|           ..|: |.|.:.|.......|.|::...:| |..:...:...|.::..|:| :
Zfish   593 LW-----------TAPE-HMRVEGISQKGDVYSFAIISQEII-LRKSPFHTSCCSDMAEKLYL-V 643

  Fly   871 SNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQ 935
            .....|:|........|.|:..|.       :||    ||.||         ..:...|.|...:
Zfish   644 QYPRGPNVFRPDLSFEGVGETEAE-------LFV----LIKSC---------WEEDPEKRPDFKR 688

  Fly   936 TILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVI 1000
              :|.....:|.|                                                    
Zfish   689 --IEGALGKIFSN---------------------------------------------------- 699

  Fly  1001 AQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVA--RTDFLWKAKLK 1063
                         ::|.||.::           :..:|..|....|..|::.  ||     |..|
Zfish   700 -------------LHNQANASY-----------MDNLIRRLQMYSRNLEHLVEERT-----ALYK 735

  Fly  1064 VEQEEVETMRGINKILLENILPAHVATHFLHLER-STELYHESYSCVAVMFASIPNYKEFYDETD 1127
            .|::..:.:..:       :||..|........| ..|||.|    |.:.|:.|..:      |.
Zfish   736 AERDRADQLNFM-------LLPGPVVRSLKETGRVEPELYDE----VTIYFSDIVGF------TT 783

  Fly  1128 V--NKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADE 1190
            :  :...:|.:.:||:|..:||.:|   ....:.|::||...||.||||              ..
Zfish   784 ICHHSTPMEVVDMLNDIYKNFDSIL---DHHDVYKVETIGDAYMVASGL--------------PR 831

  Fly  1191 KRTEEHNVVILVEFAIALMSILDSINRESFQRFRL-------RIGLNHGPVIAGVIGAQKPQYDI 1248
            .....|    .|:..:..:.||:.:.  :||...|       |||::.||..|||:|.:.|:|.:
Zfish   832 CNGNRH----AVDICLMALDILEFMG--TFQLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCL 890

  Fly  1249 WSNTVNVASRMDSCGVMGRLQTTENTAKILMTAG--YECECRGLTYVKGKGNLVTYFV 1304
            :.:|||.||||:|.|:..|:..:|:|.|||....  :|||.||.|::||||..:||::
Zfish   891 FGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWL 948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 29/241 (12%)
CYCc 259..467 CDD:214485 31/214 (14%)
Guanylate_cyc 311..469 CDD:278633 23/160 (14%)
BASP1 510..667 CDD:283191 28/184 (15%)
CYCc 1079..1283 CDD:214485 61/215 (28%)
Guanylate_cyc 1101..1305 CDD:278633 68/215 (32%)
gucy2caXP_009297342.1 Periplasmic_Binding_Protein_Type_1 31..365 CDD:299141 79/538 (15%)
PKc_like 428..698 CDD:304357 63/380 (17%)
Pkinase_Tyr 451..689 CDD:285015 58/344 (17%)
CYCc 736..929 CDD:214485 62/232 (27%)
Guanylate_cyc 763..950 CDD:278633 69/219 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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