DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and adcy6a

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	1384	Identity:	426/1384 - (30%)
Similarity:	618/1384 - (44%)	Gaps:	350/1384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NHNAETAKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDAL--SASLADLSEQENGTTAEDI 65
            :|..:....|.|....:..:...||:.         ..|..|.|  ..|..|.:......||.|.
Zfish    90 DHYGKMGSGGEGVGLKSVDLGFEDGDV---------KGRKRDGLGGDGSSEDTASGTGSVTAADC 145

  Fly    66 ----------------HLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIG------------- 101
                            .|..||.||..||.:|     .||.|:..:| |:.|
Zfish   146 WQRVVRVFQSKKFQSRKLERLYQRYFFRLNQS-----SLTMLMGVLV-IVCGVMLTFHCIHGPPD 204

  Fly   102 IVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLP 166
            :||...|...|.|.||.::..:.....|....:.|........||..|.:..:|..:..|.....
Zfish   205 VVYASVLSVAMALFLALMVVCNRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSASEGIWWS 269

  Fly   167 MYALFLCIHSMLPISWPVSVVLALFMTAIHIV--YRIGTSPDYAPNLPMLFGEIVMLASASVSGL 229
            ::.::: |:::||:....:|:....::|||::  :||....::.  ...|...:::....::.|:
Zfish   270 VFFIYI-IYTLLPVRMRAAVLSGGVLSAIHLLTTWRINQDDEFL--WKQLSANVLIFLCTNIIGI 331

  Fly   230 YYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRA 294
            .....::.:..:....||..|:.|:.|:.|.:|||:|||||:|.::|.|:|..|..|..|
Zfish   332 CTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAKKED----- 391

  Fly   295 GGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCL 359
                    ..||::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||
Zfish   392 --------MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCL 448

  Fly   360 RIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLG 424
            ||||||||||||||||..|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||
Zfish   449 RIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLG 513

  Fly   425 LRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYL 489
            ||||||||||:|||||||||:||.|||:||||.||.:|...:|||.|.||.|:|||.::.:|::|
Zfish   514 LRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLKENSIETFL 578

  Fly   490 IVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEK 554
                          |:.|.:              |..|:.                    .:..|
Zfish   579 --------------VLGCSQ--------------KRKDEK--------------------AMMAK 595

  Fly   555 MSPTSINSQEA--PLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGG 617
            |..|..||.||  |...|                                |:.....|:.|.
Zfish   596 MQRTRTNSNEALVPRWVP--------------------------------DRSFSRTKDSKV--- 625

  Fly   618 HRGSG-DSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAAS 681
            .|..| |..:|:                         .|.||| ::.||..
Zfish   626 FRQMGIDETSSK-------------------------DNRGAQ-EALNPED-------------- 650

  Fly   682 NSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMT 746
                  |..|                       |: ||.:...|.:..|.  .||
Zfish   651 ------EVDE-----------------------FL-GRAIDARSIDQLRK--DHV---------- 673

  Fly   747 KYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNT 811
                                                                   |.|.:.::.:
Zfish   674 -------------------------------------------------------KKFLLTFQTS 683

  Fly   812 PREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNM-SV 875
            ..|..|..:.|..|...:.|..::|..::.:|::|....|.:||..::.|:.||..|::..: |.
Zfish   684 SLEKKYAKKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSC 748

  Fly   876 PDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCA-VFSVINYTVPDGVSKEPSSNQTILE 939
            ..:..:..:......|.:.:....:.:|.::.:.||:.. :||.....:.|.|:|         :
Zfish   749 VKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVDCVAK---------Q 804

  Fly   940 SNFSSVFVNSTLEDVQLWEIDYAIPIAP----------VFLYCCAISLAAISAFLRSGFILKLIA 994
            .|:||..|...:.......:...:.|.|          .|.|...::|.|.|.||:...|.||..
Zfish   805 LNWSSEMVTPCIIHNMSRSVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFLQISSIGKLAL 869

  Fly   995 MLVAVIA--------QVTVLGYSDLFE-----MYNDA------NIT--------HGLPLEIKGFL 1032
            ||:..:.        :|.:...:|||.     ::|:.      |.|        ..:.|::...:
Zfish   870 MLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPV 934

  Fly  1033 LLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE- 1096
            :|.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|||..|
Zfish   935 ILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARER 999

  Fly  1097 RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161
            |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.|:..:|||
Zfish  1000 RNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKI 1064

  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLR 1226
            |||.||||.||||.....|          |....| :..|.::|:.|...:..||..||..|:::
Zfish  1065 KTIGSTYMAASGLNDSTYD----------KEGRSH-ITALADYAMHLREQMKYINEHSFNNFQMK 1118

  Fly  1227 IGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLT 1291
            ||||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|.:.||:.||||:.
Zfish  1119 IGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVI 1183

  Fly  1292 YVKGKGNLVTYFVKTPFDG 1310
            .|||||.:.|||:.   ||
Zfish  1184 KVKGKGEMTTYFLN---DG 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	59/236 (25%)
		CYCc	259..467	CDD:214485	126/207 (61%)
		Guanylate_cyc	311..469	CDD:278633	109/157 (69%)
		BASP1	510..667	CDD:283191	24/159 (15%)
		CYCc	1079..1283	CDD:214485	109/204 (53%)
		Guanylate_cyc	1101..1305	CDD:278633	109/203 (54%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	72/328 (22%)
		Guanylate_cyc	397..570	CDD:306677	117/172 (68%)
		DUF1053	609..696	CDD:310728	29/258 (11%)
		Guanylate_cyc	1004..1197	CDD:306677	109/203 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810