Protein Alignment Ac76E and adcy6a

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1384
• Identity: 426/1384 - (30%)
• Similarity: 618/1384 - (44%)
• Gaps: 350/1384 - (25%)

  Fly     3 NHNAETAKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDAL--SASLADLSEQENGTTAEDI 65
            :|..:....|.|....:..:...||:.         ..|..|.|  ..|..|.:......||.|.
Zfish    90 DHYGKMGSGGEGVGLKSVDLGFEDGDV---------KGRKRDGLGGDGSSEDTASGTGSVTAADC 145

  Fly    66 ----------------HLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIG------------- 101
                            .|..||.||..||.:|     .||.|:..:| |:.|
Zfish   146 WQRVVRVFQSKKFQSRKLERLYQRYFFRLNQS-----SLTMLMGVLV-IVCGVMLTFHCIHGPPD 204

  Fly   102 IVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLP 166
            :||...|...|.|.||.::..:.....|....:.|........||..|.:..:|..:..|.....
Zfish   205 VVYASVLSVAMALFLALMVVCNRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSASEGIWWS 269

  Fly   167 MYALFLCIHSMLPISWPVSVVLALFMTAIHIV--YRIGTSPDYAPNLPMLFGEIVMLASASVSGL 229
            ::.::: |:::||:....:|:....::|||::  :||....::.  ...|...:::....::.|:
Zfish   270 VFFIYI-IYTLLPVRMRAAVLSGGVLSAIHLLTTWRINQDDEFL--WKQLSANVLIFLCTNIIGI 331

  Fly   230 YYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRA 294
            .....::.:..:....||..|:.|:.|:.|.:|||:|||||:|.::|.|:|..|..|..|
Zfish   332 CTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAKKED----- 391

  Fly   295 GGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCL 359
                    ..||::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||
Zfish   392 --------MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCL 448

  Fly   360 RIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLG 424
            ||||||||||||||||..|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||
Zfish   449 RIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLG 513

  Fly   425 LRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYL 489
            ||||||||||:|||||||||:||.|||:||||.||.:|...:|||.|.||.|:|||.::.:|::|
Zfish   514 LRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLKENSIETFL 578

  Fly   490 IVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEK 554
                          |:.|.:              |..|:.                    .:..|
Zfish   579 --------------VLGCSQ--------------KRKDEK--------------------AMMAK 595

  Fly   555 MSPTSINSQEA--PLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGG 617
            |..|..||.||  |...|                                |:.....|:.|.
Zfish   596 MQRTRTNSNEALVPRWVP--------------------------------DRSFSRTKDSKV--- 625

  Fly   618 HRGSG-DSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAAS 681
            .|..| |..:|:                         .|.||| ::.||..
Zfish   626 FRQMGIDETSSK-------------------------DNRGAQ-EALNPED-------------- 650

  Fly   682 NSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMT 746
                  |..|                       |: ||.:...|.:..|.  .||
Zfish   651 ------EVDE-----------------------FL-GRAIDARSIDQLRK--DHV---------- 673

  Fly   747 KYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNT 811
                                                                   |.|.:.::.:
Zfish   674 -------------------------------------------------------KKFLLTFQTS 683

  Fly   812 PREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNM-SV 875
            ..|..|..:.|..|...:.|..::|..::.:|::|....|.:||..::.|:.||..|::..: |.
Zfish   684 SLEKKYAKKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSC 748

  Fly   876 PDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCA-VFSVINYTVPDGVSKEPSSNQTILE 939
            ..:..:..:......|.:.:....:.:|.::.:.||:.. :||.....:.|.|:|         :
Zfish   749 VKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVDCVAK---------Q 804

  Fly   940 SNFSSVFVNSTLEDVQLWEIDYAIPIAP----------VFLYCCAISLAAISAFLRSGFILKLIA 994
            .|:||..|...:.......:...:.|.|          .|.|...::|.|.|.||:...|.||..
Zfish   805 LNWSSEMVTPCIIHNMSRSVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFLQISSIGKLAL 869

  Fly   995 MLVAVIA--------QVTVLGYSDLFE-----MYNDA------NIT--------HGLPLEIKGFL 1032
            ||:..:.        :|.:...:|||.     ::|:.      |.|        ..:.|::...:
Zfish   870 MLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPV 934

  Fly  1033 LLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE- 1096
            :|.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|||..|
Zfish   935 ILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARER 999

  Fly  1097 RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161
            |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.|:..:|||
Zfish  1000 RNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKI 1064

  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLR 1226
            |||.||||.||||.....|          |....| :..|.::|:.|...:..||..||..|:::
Zfish  1065 KTIGSTYMAASGLNDSTYD----------KEGRSH-ITALADYAMHLREQMKYINEHSFNNFQMK 1118

  Fly  1227 IGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLT 1291
            ||||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|.:.||:.||||:.
Zfish  1119 IGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVI 1183

  Fly  1292 YVKGKGNLVTYFVKTPFDG 1310
            .|||||.:.|||:.   ||
Zfish  1184 KVKGKGEMTTYFLN---DG 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	169/412 (41%)
		Guanylate_cyc	310..469	CDD:425528	109/158 (69%)
		Guanylate_cyc	1101..1305	CDD:425528	109/203 (54%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	72/328 (22%)
		Guanylate_cyc	397..559	CDD:425528	110/161 (68%)
		Adcy_cons_dom	609..697	CDD:461877	29/259 (11%)
		Guanylate_cyc	1004..1197	CDD:425528	109/203 (54%)