DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and adcy7

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	1315	Identity:	441/1315 - (33%)
Similarity:	641/1315 - (48%)	Gaps:	289/1315 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EDIHLNDLYTRYR--QRLRKSLFRSGLLTSLLACVV---------------SIIIGIVYGQHLVQ 110
            :::....||.::.  .:.|:.:...||  |::.|..               .|.:|:|.|
Zfish    12 QELKQEALYRKFSGISQYRQFVLLLGL--SIVTCATLLVLFFSFKLKAQNHGIFVGVVGG----- 69

  Fly   111 TMLLVLAALISGSILTALQ-FPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYA-LFLC 173
            .:.|.||..:.....|..| :..:|.....|....:..||...|.:.:.......:|.:. :.:.
Zfish    70 ALCLFLAVFVLVCTETLSQRWRTLLGLGVWATHLTMGFTFIFSTKSDLQIQPWDQVPFFLFIIIT 134

  Fly   174 IHSMLPISWPVSVVLALFMTAIHI----VYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIM 234
            :::|||.....:|:|::..:..||    ||.........|....|....|:.....:.|::::::
Zfish   135 VYTMLPFQMSYAVILSIISSLSHIIVLSVYLTVAQLHSNPITFQLLSNAVVFGCGIMVGIFHKVL 199

  Fly   235 SDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQ---RAGG 296
            .:.|..:|...|...:..|:|||.|:.|||.||.||:|.||:.::|.:||    :.|:   :...
Zfish   200 MEKALKQTFQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIM----ERCKCKDKEEQ 260

  Fly   297 QASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRI 361
            |.......||.|:|:||.||:||:||||.||.|:|..:..:||..||:|||:|||||:||:|:||
Zfish   261 QRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENECMRI 325

  Fly   362 KILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLR 426
            ||||||||||||||:|.|.||.|||.|||.|.:||:.||||||::::||:|:|:|||||||:|||
Zfish   326 KILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLCGVIGLR 390

  Fly   427 KWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIV 491
            ||||||||.||||||||||||:.||||||:.||..|...:|||:|.|..||.||.:..::::|::
Zfish   391 KWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAYEVEEGNGHLRDTYLKELNIKTFLVI 455

  Fly   492 PPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMS 556
            .|:                                  |.:::.:|           |:|...::|
Zfish   456 DPR----------------------------------SKDSSLMA-----------PSITKPRVS 475

  Fly   557 PTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANG-GHRG 620
            .            .|...||:.:....       |:....:|..|.....:.:.:...|| ||
Zfish   476 D------------GLKMRASVRMTRFL-------ESWGAVKPFAHLQSREEFNTDAMVNGKGH-- 519

  Fly   621 SGDSAASESVAKSAAL-SLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSL 684
                      .|...| |:|                      :.||.|...:...|..
Zfish   520 ----------CKDIPLRSVP----------------------THNPDSFDESLEEPFS------- 545

  Fly   685 TVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYV 749
              ..||..|                                           |.||..|:.||:.
Zfish   546 --LPAPPLS-------------------------------------------TYNRNKSQKTKFD 565

  Fly   750 ECWGADRPFANIAESKLVKNIG--LASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTP 812
            |          ....|:...|.  .:|...::|.                  |:...|:|:....
Zfish   566 E----------ELHDKMTTTINDLSSSKQWVKSE------------------EISGLTLWFTKKD 602

  Fly   813 REAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIV----IELNLALLGSLLASFVSLALFLYLSNM 873
            .|..||.....:|::.:.||..:|:.:.::|::|    |||.|..  ::||.|:.|.|.:
Zfish   603 LEMQYRTIEMPNFKYYIGCATFIFICIFIIQMLVTKQRIELGLGF--AVLACFLLLILCI----- 660

  Fly   874 SVPDVHASTTERNGPGQVVASSRYLRLAMFVV----VNILISSCAVFSVINYTVPDGVSKEPSSN 934
                ..|...:|..|.::.:.:..|.|:..||    |.||:::.|...::...:.:...|:..:.
Zfish   661 ----CFADHIQRMFPEKLKSCTWLLALSKAVVKRPFVRILLATVATTVIVVIAMFELFLKKTDNL 721

  Fly   935 QTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAV 999
            ..:|:.|  |.|.:|..:::|         ..|..:|.|.::|.|...|||..|.|||..:|:..
Zfish   722 CDLLQQN--SSFADSARDELQ---------YLPYLVYNCILALIACGVFLRVSFELKLAFLLIVS 775

  Fly  1000 IAQVTVLGYS--DLFEMYNDANITH------------GL---PLEIKGFLLLLVIILVLHTLDRQ 1047
            :...|::.||  :||..||....|:            ||   | :|...:.:.:.:..:..:.||
Zfish   776 LVSYTIILYSQENLFSNYNCLLYTNHSCGDSLMVCKAGLMKHP-KIMSCIYITLFLFTMLLISRQ 839

  Fly  1048 GEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTE------------ 1100
            .||..|.|||.|.|...::||||....:|::||||:||||||..|:...:..|
Zfish   840 NEYCCRQDFLLKNKNLADKEEVELCENLNRLLLENVLPAHVAALFVGENKKNEVGLLSAISLLNR 904

  Fly  1101 ----LYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161
                ||::||.||.|||||:|::||||.|.|:||:||||||||||||.|||:||.||||||:|||
Zfish   905 KYKDLYYKSYDCVCVMFASVPDFKEFYTECDINKEGLECLRLLNEIIADFDELLSKPKFSGVEKI 969

  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLR 1226
            |||.||||.|:||     .|...:|..|.:| :...:..:|||||||:..||.|||.||..||||
Zfish   970 KTIGSTYMAAAGL-----SGPPEQSNQDRER-QNAQIGNMVEFAIALIGKLDGINRHSFNTFRLR 1028

  Fly  1227 IGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLT 1291
            :|:||||||||||||:|||||||.|||||||||:|.|.:|::|.||.|:.:|...||.||||||.
Zfish  1029 VGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETSIVLQNLGYSCECRGLI 1093

  Fly  1292 YVKGKGNLVTYFVKT 1306
            .|||||.|.|:||.|
Zfish  1094 NVKGKGELKTFFVCT 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	56/244 (23%)
		CYCc	259..467	CDD:214485	127/210 (60%)
		Guanylate_cyc	311..469	CDD:278633	108/157 (69%)
		BASP1	510..667	CDD:283191	21/158 (13%)
		CYCc	1079..1283	CDD:214485	127/219 (58%)
		Guanylate_cyc	1101..1305	CDD:278633	131/203 (65%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	32/118 (27%)
		Guanylate_cyc	272..455	CDD:306677	119/182 (65%)
		DUF1053	487..613	CDD:310728	35/246 (14%)
		Guanylate_cyc	909..1106	CDD:306677	130/202 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1816
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	719	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.840