DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and adcy2a

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	1317	Identity:	441/1317 - (33%)
Similarity:	636/1317 - (48%)	Gaps:	343/1317 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIII----GIVYGQHL--VQTMLLVLAALISGSIL 125
            |.|.|.|..|:....:|.  ||..:.||:..:.:    |:....|:  |.|:...||..::..:|
Zfish    92 LYDSYHRMSQQHPLIVFL--LLIVMGACLALLAVFFASGLDIEDHVAFVITVPTALAIFLTIFVL 154

  Fly   126 TALQ--FPAVLSSPAAALAFAIV---TTFSLGTIAAITGDELAPLPMYALFL----CIHSMLPIS 181
            ..::  |..:|.      .|::|   ...::|.:....|..:.|....:.||    .:::|||.|
Zfish   155 VCIESVFKKLLR------VFSLVIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIIFVVYTMLPFS 213

  Fly   182 WPVSVVLALFMTAIH-IVYRI---GTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRT 242
            ...:::.::...:.| :|..:   .|.....|.:..:...:::....:|:|.|::.:.:.|..:|
Zfish   214 MRDAIIASVLTASSHTVVLSVCLSSTVSHVEPLVWQILANVIIFICGNVAGAYHKHLMELALKQT 278

  Fly   243 VDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHE 307
            ...|...|:..:|||.|:.|||:||||::||:||..:|..|:.::...   ..||.. :...||.
Zfish   279 YQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGP---KFGQVE-NTNNFHN 339

  Fly   308 LHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVS 372
            |:|||||||:||:||||.||.|:|..:..:||..||:|||:|||||:||:|:|||||||||||||
Zfish   340 LYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVS 404

  Fly   373 GLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDV 437
            |||.|.|.||.|||.|||.|.:||:.||:|||:.:.||:|:|:|||||||:||:|||:||||.||
Zfish   405 GLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDV 469

  Fly   438 TLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVP 502
            |||||||:|||.||||||.:||:.|...::||.|.|..||.||.:|.|.:||::.||
Zfish   470 TLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQERDPYLKEHGVITYLVINPK-------- 526

  Fly   503 RVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPL 567
                 :|:..|                                               .....|.
Zfish   527 -----VERKSP-----------------------------------------------QHYYRPR 539

  Fly   568 HAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAK 632
            |.
Zfish   540 HT--------------------------------------------------------------- 541

  Fly   633 SAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKL 697

Zfish   542 ----------------------------------------------------------------- 541

  Fly   698 SVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIA 762
                              |:|.|:                  |.|.:||:|:|.|||.:||||:.
Zfish   542 ------------------IDGAKM------------------RASVRMTRYLESWGAAKPFANLH 570

  Fly   763 ESKLVKN----IGLASIAMIE------SNLLPPERKCFN--------FNFFG--------PPTEL 801
            ....:.|    |..|.:.:.:      |.....::|.|.        ..|.|        ...::
Zfish   571 HRDSMTNENGKINTADVPIGQYHFQRRSERTKSQKKRFEEELNERMIRTFDGINSQKQWLKSEDI 635

  Fly   802 KPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLG-SLLASFVSLA 865
            :..::::.|...|..|||.....|::.:.||.::|..:.:||::|:. ..|:|| |...||:.|:
Zfish   636 QRISLFFHNKALEKEYRATTLPAFKYYITCACLIFFCIFIVQILVLP-KTAILGVSFGMSFLILS 699

  Fly   866 LFLYLSNMSVPDVHASTTERNGPGQ---------VVASSRYLRLAMFVVVNILISSCAVFSVI-- 919
            :.|.:..:.    |....::.....         ::||..:.|:.:.:....||...|||::.
Zfish   700 VILLVCFIG----HFLQCKKTASASWVWILRSSGIIASKPWPRITLTMATTALILIMAVFNMFFI 760

  Fly   920 --NYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISA 982
              |.|:.:.|..  :||:|:|:.:...:..           :|......|.|:|.|.:.|.:.|.
Zfish   761 EDNLTLMETVYN--TSNETLLQPDGQPIPY-----------LDKNTFYLPYFIYSCILGLISCSV 812

  Fly   983 FLRSGFILKLIAMLVAVIAQVTVL--GYSDLFEMYN------DANITHGLPLEIK--GFLLLLVI 1037
            |||..:.||::.||.||:....::  .::.|.:.|:      :.....|:..::|  |.:.|.:.
Zfish   813 FLRINYELKMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVSLFIF 877

  Fly  1038 ILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-RSTEL 1101
            .:.|..|.||.||..|.|||||.|.|.|.||:|||..:|::||||:||||||.|||... ::.:|
Zfish   878 FITLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWKNEDL 942

  Fly  1102 YHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIAS 1166
            ||:||..|.|||||||::||||.|:||||:||||||||||||.|||:||.||||||:||||||.|
Zfish   943 YHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGS 1007

  Fly  1167 TYMCASGLR--PGKEDGATSRSFADEKRTEEH-----NVVILVEFAIALMSILDSINRESFQRFR 1224
            |||.|:||.  ||.|            .|:||     ::..:||||.||:..||.||:.||..|:
Zfish  1008 TYMAATGLNATPGPE------------YTQEHDRQYMHIGTMVEFAFALVGKLDVINKHSFNDFK 1060

  Fly  1225 LRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRG 1289
            ||:|:|||||.||||||||||||||.|||||||||||.||:|::|.||.|:.||.|.||.|.|||
Zfish  1061 LRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCILQTLGYTCSCRG 1125

  Fly  1290 LTYVKGKGNLVTYFVKT 1306
            :..|||||.|.||||.|
Zfish  1126 IINVKGKGELKTYFVHT 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/240 (24%)
		CYCc	259..467	CDD:214485	126/207 (61%)
		Guanylate_cyc	311..469	CDD:278633	106/157 (68%)
		BASP1	510..667	CDD:283191	3/156 (2%)
		CYCc	1079..1283	CDD:214485	133/211 (63%)
		Guanylate_cyc	1101..1305	CDD:278633	135/210 (64%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	57/234 (24%)
		CYCc	295..498	CDD:214485	126/206 (61%)
		Guanylate_cyc	340..524	CDD:278633	120/183 (66%)
		DUF1053	554..658	CDD:283888	23/103 (22%)
		CYCc	912..1120	CDD:214485	136/219 (62%)
		Guanylate_cyc	942..1141	CDD:278633	135/210 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1816
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75133
Inparanoid	1	1.050	719	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4464
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870