Protein Alignment Ac76E and adcy5

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001165056.1
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1186
• Species: Danio rerio
• Alignment Length: 1370
• Identity: 416/1370 - (30%)
• Similarity: 622/1370 - (45%)
• Gaps: 350/1370 - (25%)

  Fly     3 NHNAETAKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHL 67
            |:|..:.:..:|.....::.:..:...|:.|........:|.::||....:.:.......:...|
Zfish    92 NNNRSSPRYRDGEVRPKSVELGLEDRRTKSKPEEELMPEVNFSMSACCNSVMQIFRSKKFQSEKL 156

  Fly    68 NDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTML-LVLAALISGSILTALQFP 131
            ..||.||..||.:|     .||.|:|.:| ::..::.|.|....|. |....:.:.:|:..|...
Zfish   157 ERLYQRYFFRLNQS-----SLTMLMAVLV-LVCAVMLGFHCAGGMCQLTFVLVFTAAIVLILTLM 215

  Fly   132 AVLSSPA---------------AALAFAIVTTFSLGTIAAITGDELAPLPMYALFL--CIHSMLP 179
            .|.:..:               ..||..:|....:...:|..|      ..:.:|.  .|:::||
Zfish   216 VVCNRNSFHQDHMWIVCYLLILLVLAVQVVGVLFVKPRSASEG------IWWTVFFIHVIYTLLP 274

  Fly   180 ISWPVSVVLALFMTAIHIV--YRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRT 242
            :....:|:..:.::|||::  :|:.....:.  ...|...:::.:.:::.|:.....::.:..:.
Zfish   275 VRMRAAVITGIILSAIHVLISWRLNDMDVFL--WKQLVSNVLIFSCSNIVGVCTHYPAEGSQRQA 337

  Fly   243 VDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHE 307
            ...||..|:.|:..:.|.:|||:|||||:|.::|.|:|..|..|..|             ..||:
Zfish   338 FQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADINAKQED-------------MMFHK 389

  Fly   308 LHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVS 372
            :::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.|||||||||||||||
Zfish   390 IYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVS 454

  Fly   373 GLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDV 437
            |||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:||
Zfish   455 GLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDV 519

  Fly   438 TLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVP 502
            |||||||:||.|||:||||.||::|...::||.|.||.|:.||..|.:|:|||
Zfish   520 TLANHMEAGGKAGRIHITKATLNYLNGDYDVEPGSGGERNVYLKKHNIETYLI------------ 572

  Fly   503 RVVECIEQNDPSPTTEETKEIKETDQ------SHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
              |.|.::.     .||...|.:.::      :|.:|...|
Zfish   573 --VGCSQKR-----KEEKAMIAKMNRQRTNSVTHNSTHWTD------------------------ 606

  Fly   562 SQEAPLHAPL-ASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSA 625
               .|.:..| |::.|..:|.:. .||..|:.|          |:..|.::
Zfish   607 ---RPFYNHLNANSVSKEMKRMG-FEDPKDKNT----------QENLNPED-------------- 643

  Fly   626 ASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAP 690
                         ..|:.|
Zfish   644 -------------EVDEFL---------------------------------------------- 649

  Fly   691 ERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGAD 755
                                       ||.:...|.:..||.  ||
Zfish   650 ---------------------------GRAIDARSIDRLRSE--HV------------------- 666

  Fly   756 RPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQ 820
                                                          |.|.:.:|....|..|..|
Zfish   667 ----------------------------------------------KKFLLTFREPDLEKKYSKQ 685

  Fly   821 PDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNM-------SVPDV 878
            .|:.|...:.||.::||.:..:|:|::..:..::|..:...|.|.:.:::|.:       .:|
Zfish   686 VDSSFGAYVACASLVFLFICFIQIIIVPHSGLMVGFYVLCLVVLMVVMFISAIYSCFGFFPIP-- 748

  Fly   879 HASTTERNGPGQVVASSRY--LRLAMFVVVNILISSCAVFSVINYTVPD---------GVSKEPS 932
             ..|..:.     :..||.  ..:.:|.:|.:.||  |..::...:..|         .:|   .
Zfish   749 -LQTLSKR-----IVQSRLNSTLVGVFTIVLVFIS--AFINIFTCSTDDLKTCLGQEFNIS---P 802

  Fly   933 SNQTILESNFSSVFVNSTLEDVQLWE----IDYAIP---IAPVFLYCCAISLAAISAFLRSGFIL 990
            ||.....::|||  :|.|     ||.    .:.:.|   ....|..|..:||.|.|.||:...|.
Zfish   803 SNVNACHAHFSS--LNYT-----LWSQNRLCNSSSPTCNFPEYFSSCVLLSLLACSVFLQVSSIG 860

  Fly   991 KLIAM--------LVAVIAQVTVLGYSDLFEMYNDANITHG-------LPLEIKGFLLLLVIILV 1040
            ||..|        |:..:.:|::....||..|.|.....:|       :||:|...:::.|.:|.
Zfish   861 KLFLMLFIEILYVLIMEVPEVSLFDNVDLLVMANALAPNNGTCIVDTRVPLKIVTPVVITVFVLA 925

  Fly  1041 LHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-RSTELYHE 1104
            |:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|||..| |:.|||::
Zfish   926 LYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQ 990

  Fly  1105 SYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYM 1169
            |..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:|..:||||||.||||
Zfish   991 SCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYM 1055

  Fly  1170 CASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPV 1234
            .||||.....|.| .||          ::..|.::|:.||..:..||..||..|:::||||.|||
Zfish  1056 AASGLNDSTYDKA-GRS----------HIRALADYAMRLMDQMKYINEHSFNNFKMKIGLNMGPV 1109

  Fly  1235 IAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNL 1299
            :||||||:|||||||.|||||||||||.||..|:|.|.:..::|.:..|..|.||:..|||||.:
Zfish  1110 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPERIQVTTDLYQVLSSYNYTLEYRGVVKVKGKGEM 1174

  Fly  1300 VTYFV 1304
            :|||:
Zfish  1175 MTYFL 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	55/241 (23%)
		CYCc	259..467	CDD:214485	126/207 (61%)
		Guanylate_cyc	311..469	CDD:278633	108/157 (69%)
		BASP1	510..667	CDD:283191	19/163 (12%)
		CYCc	1079..1283	CDD:214485	111/204 (54%)
		Guanylate_cyc	1101..1305	CDD:278633	109/204 (53%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831	64/322 (20%)
		CYCc	354..548	CDD:214485	126/206 (61%)
		Guanylate_cyc	390..574	CDD:278633	121/197 (61%)
		DUF1053	598..687	CDD:283888	29/293 (10%)
		CYCc	961..1155	CDD:214485	112/204 (55%)
		Guanylate_cyc	987..1181	CDD:278633	109/204 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810