Protein Alignment Ac76E and si:dkey-206f10.1

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_009293230.1
• Gene: si:dkey-206f10.1 / 560719
• ZFINID: ZDB-GENE-041014-154
• Length: 1187
• Species: Danio rerio
• Alignment Length: 1371
• Identity: 386/1371 - (28%)
• Similarity: 577/1371 - (42%)
• Gaps: 418/1371 - (30%)

  Fly    33 KAMT---SSAARMNDALSASLADLSEQENGTTAE----------------DIH------------ 66
            :.||   ||.||::.:.....:..|..:.||:.:                .:|
Zfish    79 RGMTKRRSSVARVHPSFFGERSSSSSTQTGTSVDYISDADFFVHWGNIIHGVHVPTLRHIFKSKD 143

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFP 131
            |..||.|:....|:        |||   ||:.||......||   .||.||.....|.:....|.
Zfish   144 LEKLYQRHSSHTRR--------TSL---VVTNIIDAAAKLHL---FLLYLALAPDRSDILMSWFT 194

  Fly   132 AVLSSPAAALAFAIVT---------------TFSLGTIAAITGDELAPL----PMYALFLCIHSM 177
            ....:.|.||...::|               ...|...|.:.|.....|    ..|.||....:.
Zfish   195 GFFMACAIALCVLVLTCKRSHSPKWLHYAGMASWLSQTAQVLGGLAYGLERDQSWYVLFTLFATY 259

  Fly   178 ----LPISWPVSV-----VLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRI 233
                ||:.|.:..     :|.|....|..:..:|.       ...|..:.::..|.:|:||:...
Zfish   260 TLLPLPLLWAIGAGTLTSILHLTAETIRHISEVGL-------FRKLLAKALLYTSMNVAGLFIHY 317

  Fly   234 MSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQA 298
            ::|.:..:....||..||.|:|||.|.::||:|:||::|.::|.|: .|.|..|.|
Zfish   318 LTDRSQRQAFLETRRCIEGRMKLETENQRQERLVLSILPRFVALEM-ISDMTSMDD--------- 372

  Fly   299 STSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKI 363
            .....:||::::.::.:|:||||||..||.||.:::|.:||:.||:||||||::|:|..||||||
Zfish   373 ELDPQQFHKVYIHQYKDVSILFADIKGFTLLSMNMSAQELVRLLNELFGRFDRLAEEYDCLRIKI 437

  Fly   364 LGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKW 428
            ||||||||||:|..:..||..||.|||.||..:|.:|:....::|||||||||:||||||||:||
Zfish   438 LGDCYYCVSGVPEPQRAHARCCVEMGLAMISTMRSLRKQQNFDMDMRIGIHTGSVLCGVLGLQKW 502

  Fly   429 QFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPP 493
            ||||||.||.:||.:|:||:.||:||::.|||.|...|:.|.|.|..|:.:|..|.::::||
Zfish   503 QFDVWSWDVGIANMLEAGGIPGRIHISRATLDCLDGSFQTEDGRGYERNEFLRKHNIDTFLI--- 564

  Fly   494 KPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPT 558
                         |.:::|          :.|.:..|..|
Zfish   565 -------------CHKEDD----------LNEMEAEHPKT------------------------- 581

  Fly   559 SINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGD 623
              .....|.:..:.::.|                                      ||.:.....
Zfish   582 --RHNNRPWNKEILASFS--------------------------------------NGSYTQLPT 606

  Fly   624 SAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAE 688
            |:|..|::|
Zfish   607 SSACRSMSK-------------------------------------------------------- 615

  Fly   689 APERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWG 753
              |.::|                    || ..:.:.|.|..|..  |:|
Zfish   616 --EINKR--------------------IE-HAIDLRSSERMRQE--HIT---------------- 639

  Fly   754 ADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYR 818
                                                             |.|:.:::...|..:.
Zfish   640 -------------------------------------------------PVTLVFKDAHIEEKFS 655

  Fly   819 AQPDTHFRFDLICAFVLFLSLAVVQLI----------VIELNLALLGSLLASFVSLALFLYLSNM 873
            ...|..|:.:|:|:|::.|.|..||.:          |::..|.|||.||.    |.:.|.....
Zfish   656 QVRDEMFKTNLVCSFIMLLLLMAVQALIPVPRMYLWTVLQFCLFLLGYLLL----LVMVLAEEFK 716

  Fly   874 SVPDV--------HASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKE 930
            ..|.|        |.:.:.||                      |::..|:  .:|:.:
Zfish   717 HSPGVLQQFCCWIHENNSMRN----------------------LLTITAI--AMNFGM------- 750

  Fly   931 PSSNQTILESNFSSVFVNST-LEDVQLWEID---------YAIPIAPVFLYCCAISLAAISAFLR 985
                     :.|..::.||: ::::...|.:         .|.....||:....:|:...:.|||
Zfish   751 ---------ALFDMMWCNSSEMKEISTRETEGYKAGQKPLTACTYPEVFVLSGVVSMVTCAVFLR 806

  Fly   986 SGFILKLIAML--VAVIAQVTVLGYSDLF-EMYNDANITHGLPLEIKGFLLLLVIILVLHTL--D 1045
            ...:|||..:|  |||......:.:..|: ......:::....|..||..:||:.:.::..|  .
Zfish   807 MSSLLKLTILLFVVAVYTYFIEVSFHMLYVHQQEHEHLSRSHFLRRKGVSILLMAMFMIAVLYNG 871

  Fly  1046 RQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERS-TELYHESYSCV 1109
            |:.|...|.||||:.:.:.|.:|:..:|..|:.||.||||||||.|||...|: .|||.:||..|
Zfish   872 RRWEATTRLDFLWRLQAQQEVQEMRDLREHNECLLHNILPAHVARHFLERNRNDQELYSQSYDEV 936

  Fly  1110 AVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGL 1174
            .||||||..:.::|::.::..:|:|||:||||||.|||:||.:..|..|||||||.|.||.||||
Zfish   937 GVMFASIAGFNDYYEQKEIKHEGVECLKLLNEIIADFDELLEESYFLDIEKIKTIGSCYMAASGL 1001

  Fly  1175 RPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVI 1239
            .|.|:....:         :.|::..||.||:|:...|..||:.|...|:||:|:.||||:||||
Zfish  1002 SPDKQSRVVN---------DWHHLSELVLFALAMQETLREINKHSMNNFQLRVGIAHGPVVAGVI 1057

  Fly  1240 GAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKG----KGNLV 1300
            ||.|||||||..|||:||||||.||.||:|..|.|..||...|:..|.||..|:||    ||.:.
Zfish  1058 GATKPQYDIWGMTVNLASRMDSTGVSGRIQVPEATRNILADWGFVLELRGEIYIKGVSERKGRVR 1122

  Fly  1301 TYFVKT 1306
            |||:.|
Zfish  1123 TYFIST 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	157/425 (37%)
		Guanylate_cyc	310..469	CDD:425528	93/158 (59%)
		Guanylate_cyc	1101..1305	CDD:425528	105/207 (51%)
si:dkey-206f10.1	XP_009293230.1	AC_N	<135..380	CDD:318454	65/275 (24%)
		Guanylate_cyc	382..564	CDD:425528	99/181 (55%)
		Adcy_cons_dom	<603..662	CDD:461877	17/204 (8%)
		Guanylate_cyc	928..1126	CDD:425528	104/206 (50%)