DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and si:ch211-132f19.7

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_688903.4	Gene:	si:ch211-132f19.7 / 560410	ZFINID:	ZDB-GENE-130530-619	Length:	1183	Species:	Danio rerio

Alignment Length:	1349	Identity:	403/1349 - (29%)
Similarity:	618/1349 - (45%)	Gaps:	359/1349 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ADGNATQPKAMTSSA------ARMNDALSASLADLSEQEN----GTTAEDIHLNDLYTRYRQRLR 79
            |.|||...|..:|:|      .|.:.....|...:::.:.    |:|...|.|..|:.:::....
Zfish    75 ARGNAGMHKRRSSAARIHPFRERNSTCTRKSTESVTDADFFVSWGSTVRGIFLPALHHKFKSHDL 139

  Fly    80 KSLFR---SG------LLTSLLACVVSIIIGIVY---------GQH-LVQTMLLVLAALISGSIL 125
            :.|::   ||      ::|:::..:..:.|..:|         .|| .:..:|:.|.|:|...:|
Zfish   140 EHLYQQHSSGQRRTSLVVTNVIDILTKLHIIFIYLALAPEMVDSQHGWLAGLLMALGAIICVLVL 204

  Fly   126 TALQFPAVLSSPAAALAFAIVTTFSLGTIAAITG-------DELAPLPMYALF--LCIHSMLPIS 181
            |.    ..|.|| ..|.:|.:.::...|:.|:.|       |:    ..|.||  ..|:::||:.
Zfish   205 TC----KGLMSP-DYLRYAGLASWLSQTVQALGGLVYGLETDQ----SWYVLFTLFAIYTLLPLP 260

  Fly   182 WPVSVVLALFMTAIHIVYRIGTSPDYAPN--LPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVD 244
            ...|:.:.....|:|:.  :.|..:|...  :..|..:.::....:.:||:...:||.|..:...
Zfish   261 LLWSICMGFLTAALHLF--VDTFKNYNDTAIVRKLLAKGLLYMGMNTAGLFIHYLSDRAQRQAFL 323

  Fly   245 GTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELH 309
            .||..||.|||:|.|.::||:|::|::|.:||.|:... |..:.|         .....:||:.:
Zfish   324 ETRRCIEGRVKMERENQRQERLVMSILPRFIAMEMIGD-MTALDD---------ELLPQQFHKTY 378

  Fly   310 VQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGL 374
            ..::.:|:||||||..||.||.::.|.:||:|||:||||||::|:||.|:||||||||||||||:
Zfish   379 FHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGV 443

  Fly   375 PISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
            |..:..||..||.|||.||:.||:||:....::|||||||:|:||||||||:||||||||.||.:
Zfish   444 PEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGLQKWQFDVWSWDVDV 508

  Fly   440 ANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRV 504
            ||.:|:||:.||:||::.|||.|...:|.|:|.|..|:.:|..||::::||
Zfish   509 ANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERNEFLRKHKIDTFLI-------------- 559

  Fly   505 VECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHA 569
                     ..|.::.||                        ||     |:..||
Zfish   560 ---------RHTPQDDKE------------------------PP-----KVRRTS---------- 576

  Fly   570 PLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSA 634
                               .||.|...|
Zfish   577 -------------------KDETTWSAE------------------------------------- 585

  Fly   635 ALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSV 699
               ||.|:::.|:...:..:| |:....  |..:||..|    |:...:..:.:|
Zfish   586 ---LPFDNIIGMNCILATFTN-GSLVHL--PNQITPHCA----GSREINKRIKQA---------- 630

  Fly   700 QGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAES 764
                                 :.:.|.|..|..  |:|
Zfish   631 ---------------------IEVRSSERMRKE--HIT--------------------------- 645

  Fly   765 KLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDL 829
                                                  |||:.:::|..|..:....|..|:.:|
Zfish   646 --------------------------------------PFTLVFKDTHIEGKFSQMRDEMFKSNL 672

  Fly   830 ICAFVLFLSLAVVQLI---------VIELNLALLGSLLASFVSLALFL-----YLSNMSVPDVHA 880
            .|:|:|.|.:...|.:         :|:..:.|...:|...|:||...     ||.::.. .:|.
Zfish   673 ACSFLLLLFIMAAQALIPSPQFFPMIIQFLVFLFVYMLVLLVTLAEEFKRSPPYLQHLCC-WIHE 736

  Fly   881 STTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSV 945
            :.:.||           |.....:.:|..::||.:|               ..|.|..|:..|
Zfish   737 TKSIRN-----------LLTLTAIAINFGVASCNIF---------------WCNGTFEETEKS-- 773

  Fly   946 FVNSTLEDVQLWEIDYAIPIAP-VFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVL--- 1006
              |...|..:.|.::  |...| .|:....:::...:.|||...:||| |:|..|||..|.|
Zfish   774 --NKNSEHGKQWPVN--ICTHPEFFVLSGVVAMVTCAVFLRLSCLLKL-AVLTLVIAVYTYLIEV 833

  Fly  1007 GYSDLF-EMYNDANITHGLPLEIKGFLLLLV---IILVLHTLDRQGEYVARTDFLWKAKLKVEQE 1067
            .:..|| ..:.::.|.....|..||..:||:   :::||:. .||.|..:|.||||:.:.:.|.|
Zfish   834 AFHVLFIRQHQNSQIQRSQYLRRKGISVLLMAMFVVVVLYN-SRQLETTSRLDFLWRLQARQEVE 897

  Fly  1068 EVETMRGINKILLENILPAHVATHFLHLERSTE-LYHESYSCVAVMFASIPNYKEFYDETDVNKQ 1131
            :::.:|..|:.||.||||||||.|||..:|:.| |:.|||..|.|||||||.:.::|::.::..|
Zfish   898 DMKELREHNECLLYNILPAHVARHFLERDRNNEDLFSESYERVGVMFASIPGFSDYYEKKELIHQ 962

  Fly  1132 GLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEH 1196
            .:||||||||||.|||:||.:|.|..|||||||.|.||.||||.|.|:          |...|..
Zfish   963 DVECLRLLNEIIADFDELLDEPYFQDIEKIKTIGSCYMAASGLSPEKQ----------ECEDEWA 1017

  Fly  1197 NVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDS 1261
            ::..||.||:|:...|..||:.:...|.||:|::||||:||||||.|||||||..|||:||||||
Zfish  1018 HLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYDIWGMTVNLASRMDS 1082

  Fly  1262 CGVMGRLQTTENTAKILMTAGYECECRGLTYVKG----KGNLVTYFVKT 1306
            .|:.||:|..|.|:::|...|:..:.||..||||    :|.:.||||.:
Zfish  1083 TGLSGRIQVPEATSRVLAEHGFMLQLRGEIYVKGVSERRGAVRTYFVSS 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	60/251 (24%)
		CYCc	259..467	CDD:214485	107/207 (52%)
		Guanylate_cyc	311..469	CDD:278633	95/157 (61%)
		BASP1	510..667	CDD:283191	19/156 (12%)
		CYCc	1079..1283	CDD:214485	109/204 (53%)
		Guanylate_cyc	1101..1305	CDD:278633	105/207 (51%)
si:ch211-132f19.7	XP_688903.4	AC_N	<133..375	CDD:292831	59/262 (23%)
		CYCc	338..537	CDD:214485	107/208 (51%)
		Guanylate_cyc	381..559	CDD:278633	102/177 (58%)
		DUF1053	579..667	CDD:283888	26/232 (11%)
		CYCc	903..1103	CDD:214485	111/209 (53%)
		Guanylate_cyc	932..1131	CDD:278633	106/208 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.710