DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and ADCY10

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	196	Identity:	38/196 - (19%)
Similarity:	78/196 - (39%)	Gaps:	33/196 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 VKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
            ::|.|..:...:|.:| :..|:...:     ||..|..|..|             ::.....|||
Human   249 LRLACTLKPDPELEMS-LQKYVMESI-----LKQIDNKQLQG-------------YLSELRPVTI 294

  Fly   319 LFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQ--ENQCLRIKIL--GDCYYCVSGLPISR- 378
            :|.:::    ......|.::...:.|.:.....:.:  :.|..::.:.  |..:.||.|.|..:
Human   295 VFVNLM----FEDQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKV 355

  Fly   379 PQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLG-LRKWQFDVWSDDVTLANH 442
            |...|:.:...:.:.|....|.:...::    ||:.:|.|.||::| ..:.::.|....|.||..
Human   356 PDELTHALECAMDIFDFCSQVHKIQTVS----IGVASGIVFCGIVGHTVRHEYTVIGQKVNLAAR 416

  Fly   443 M 443
            |
Human   417 M 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	7/34 (21%)
		CYCc	259..467	CDD:214485	36/191 (19%)
		Guanylate_cyc	311..469	CDD:278633	28/139 (20%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	28/134 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900