Protein Alignment Ac76E and adcy2b

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1310
• Identity: 440/1310 - (33%)
• Similarity: 635/1310 - (48%)
• Gaps: 342/1310 - (26%)

  Fly    74 YRQRLRKSLFRSGLLTSLLACVVSIII----GIVYGQHL--VQTMLLVLAALISGSILTALQ--F 130
            ||...:..|....||..:.||:..:.:    |:...:|:  :.|:...||..::..||..::  |
Zfish    85 YRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDMEEHMAFIMTVPTTLAIFLAIFILVCIESVF 149

  Fly   131 PAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFL----CIHSMLPISWPVSVVLALF 191
            ..:|...:..:...:|   ::|.:....|..:.|....:.||    .:::|||.|...:|:.::.
Zfish   150 KKLLRLFSLLIWGCLV---AMGYLFMFFGGIICPWDQVSFFLFIVFVVYTMLPFSMRDAVIASVL 211

  Fly   192 MTAIH-IVYRI---GTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQ 252
            .::.| :|..|   .||......:..:...|::....:|:|.|::.:.|.|..:|...|...|:.
Zfish   212 TSSSHTLVLSICLSNTSDHMEALVWQILANIIIFICGNVAGAYHKHLMDLALKQTYHDTCNCIKS 276

  Fly   253 RVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGG---QASTSATRFHELHVQRHT 314
            .:|||.|:.|||:||||::||:||..:|       |:..||..|   ..:.:...||.|:|||||
Zfish   277 PIKLEFEKHQQERLLLSLLPAHIARVMK-------AEIIQRLKGPNFSQAENTNNFHNLYVQRHT 334

  Fly   315 NVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRP 379
            ||:||:||||.||.|:|..:..:||..||:|||:|||||::|.|:||||||||||||||||....
Zfish   335 NVSILYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLL 399

  Fly   380 QHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHME 444
            .||.|||.|||.|.:||..||||||::::||:|:|:|||||||:||:|||:||||.|||||||||
Zfish   400 DHAKNCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHME 464

  Fly   445 SGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIE 509
            :|||.|||||:..||:.|...::||||.|.:||:||.:|.:.:||::.||.
Zfish   465 AGGVPGRVHISSVTLEHLNGAYKVEQGNGQSRDSYLKEHGIVTYLVINPKA-------------- 515

  Fly   510 QNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASA 574
                                                       ||.||.
Zfish   516 -------------------------------------------EKRSPL---------------- 521

  Fly   575 ASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLP 639
                                                                             
Zfish   522 ----------------------------------------------------------------- 521

  Fly   640 ADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMS 704
               |||                     ::.||
Zfish   522 ---LLS---------------------AIRPT--------------------------------- 529

  Fly   705 FADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKN 769
                       :.|.|:                  |.|.:||:|:|.|||.:||||:.....:.|
Zfish   530 -----------MYGAKM------------------RASVRMTQYLESWGAAKPFANLHHRDSMTN 565

  Fly   770 IGLASIAMIESNLLP--------------PERKCFNFNF----------------FGPPTELKPF 804
                ...||.:..:|              .::|.|....                :....:::..
Zfish   566 ----ENGMINTRDVPLGQYNCQQRSERTKSQKKRFEEELNERIIRTIDGINSQKQWLKSEDIQRI 626

  Fly   805 TMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLY 869
            ::::.|...|..|||.....|::.:.||.::|..:.:||::|:.....|..|...:|:.|||.|.
Zfish   627 SLFFHNKALEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTTVLEVSFGMAFLLLALILC 691

  Fly   870 L------------SNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYT 922
            :            ::.::|.:.:|:       :|:.:..::|||:.:....||...|||::. :.
Zfish   692 ICFAGHILQWGKAASCTMPRLPSSS-------KVITNKPWIRLALTMATTALILVMAVFNMF-FL 748

  Fly   923 VPDGVSKEPSSNQTILESNFSSVF---VNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFL 984
            ..|.:....|.|  |..|:....:   .||:.....|          |.|:|.|.:.|.:.|.||
Zfish   749 GEDRMVASTSLN--ISNSSMDGPYGQITNSSNNKFYL----------PYFIYSCILGLISCSVFL 801

  Fly   985 RSGFILKLIAMLVAVIAQ--VTVLGYSDLFEMYNDANITHGLP--------LEIKGFLLLLVIIL 1039
            |..:.||:|.||.||:|.  :.:..::.:.:.|:.|......|        |:..|.:.|.:..:
Zfish   802 RINYELKMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDRPGVLKDLKTMGSISLFIFFV 866

  Fly  1040 VLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-RSTELYH 1103
            .|..|.||.||..|.||||:.|.|.|.||:|||..:|::||||:||||||.|||... ::.:|||
Zfish   867 TLLVLARQNEYYCRLDFLWRNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLGRNWKNEDLYH 931

  Fly  1104 ESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTY 1168
            :||..|.|||||||::||||.|:||||:||||||||||||.|||:||.||||||:||||||.|||
Zfish   932 QSYDTVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTY 996

  Fly  1169 MCASGLR--PGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNH 1231
            |.|:||.  ||.|       :|.....:..::..:||||.||:..||.||:.||..||:|:|:||
Zfish   997 MAATGLNVTPGLE-------YAQYHDRQYMHIGTMVEFAFALVGKLDVINKHSFNDFRMRVGINH 1054

  Fly  1232 GPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGK 1296
            ||||||||||||||||||.|||||||||:|.||:|::|.||.|..||.|.||.|.|||:..||||
Zfish  1055 GPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETNWILQTLGYMCSCRGIINVKGK 1119

  Fly  1297 GNLVTYFVKT 1306
            |:|.|:||.|
Zfish  1120 GDLRTFFVHT 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	57/230 (25%)
		CYCc	259..467	CDD:214485	124/210 (59%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	7/156 (4%)
		CYCc	1079..1283	CDD:214485	131/206 (64%)
		Guanylate_cyc	1101..1305	CDD:278633	132/205 (64%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	58/231 (25%)
		CYCc	283..486	CDD:214485	124/209 (59%)
		Guanylate_cyc	328..512	CDD:278633	117/183 (64%)
		DUF1053	542..646	CDD:283888	21/107 (20%)
		CYCc	899..1106	CDD:214485	133/213 (62%)
		Guanylate_cyc	929..1128	CDD:278633	132/205 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1816
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75133
Inparanoid	1	1.050	719	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.840