DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and npr1b

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	248	Identity:	73/248 - (29%)
Similarity:	121/248 - (48%)	Gaps:	44/248 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 IEQRVK--LECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQR 312
            :|:|.:  || |:.:.|.||..::|..:|.::||.                       ..:..:.
Zfish   842 VEERTQAYLE-EKRKAEALLYQILPHSVAEQLKRG-----------------------ETVQAEA 882

  Fly   313 HTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPIS 377
            ..:|||.|:|||.||.||:..|...:|..||||:..||.|.......:::.:||.|..|||||:.
Zfish   883 FDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVR 947

  Fly   378 RPQ-HATNCVNMGLQMIDAIR--HVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
            ..: |......|.|.:::|::  .:|......:.:|||||:|.|..||:||:..::.::.|.|..
Zfish   948 NGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNT 1012

  Fly   440 ANHMESGGVAGRVHITKQT-----------LDFLGDKFEVE-QGEGGNRDAYL 480
            ::.|||.|...::|::..|           |:..||   || :|:|..|..:|
Zfish  1013 SSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGD---VEMKGKGKMRTYWL 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	12/40 (30%)
		CYCc	259..467	CDD:214485	63/221 (29%)
		Guanylate_cyc	311..469	CDD:278633	55/171 (32%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
npr1b	XP_009290669.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900