DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gucy1a1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001296458.1	Gene:	gucy1a1 / 550420	ZFINID:	ZDB-GENE-050417-230	Length:	679	Species:	Danio rerio

Alignment Length:	366	Identity:	91/366 - (24%)
Similarity:	153/366 - (41%)	Gaps:	92/366 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 GTSPDYAPNLPM-LFGEIVMLASASV-----------------SGLYYRIMSD-AAHNRTVD--- 244
            |.|...:|...| |.|:::.::..|.                 .|||   :|| ..||...|
Zfish   357 GASSADSPGKHMDLKGQMIFMSEMSALLFLGSPCVDKLEELTGRGLY---LSDIPIHNALRDVVL 418

  Fly   245 -GTRT----GIEQRV------------KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQ 292
             |.:|    |:::|:            .||.|:.:..:||.::.|..:|               |
Zfish   419 VGEQTKAQDGLKKRLGKAKAALEQAHQALEEEKRRTVELLFTIFPGNVA---------------Q 468

  Fly   293 RAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQ 357
            |........|.:|        .:||:||:|||.||.:.|..|...:|..|::|:.|||....|..
Zfish   469 RLWQGLPVQAKKF--------DHVTVLFSDIVGFTAICSRCTPMQVVNMLSELYTRFDHHCGELD 525

  Fly   358 CLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGV 422
            ..:::.:||.|....||....|.||.....|.|:|::....|....|..:.||||||:|:||.||
Zfish   526 VYKVETIGDAYCVAGGLHKESPTHAVQIALMALKMMELSDEVTTPMGEVIRMRIGIHSGSVLAGV 590

  Fly   423 LGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVES 487
            :|::..::.::.::|||||..||..:..:::::..|...|.|                    ...
Zfish   591 VGVKMPRYCLFGNNVTLANKFESCSLPRKINVSPTTYRLLKD--------------------CPE 635

  Fly   488 YLIVPP-----KPAYTYSVPRVVECIEQND--PSPTTEETK 521
            :.::|.     .|.:...:|.|...::.:|  .:...|||:
Zfish   636 FTLIPRTREDLPPNFPTDIPGVCYFLQAHDQKTNAAPEETQ 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	26/125 (21%)
		CYCc	259..467	CDD:214485	62/207 (30%)
		Guanylate_cyc	311..469	CDD:278633	53/157 (34%)
		BASP1	510..667	CDD:283191	4/14 (29%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	27/130 (21%)
		CYCc	449..635	CDD:214485	62/228 (27%)
		Guanylate_cyc	476..647	CDD:278633	56/198 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810