DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	185/985 - (18%)
Similarity:	295/985 - (29%)	Gaps:	340/985 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LIVKADGNATQPKAMTSSAARMNDALSASLADLSEQE---------NGTTAEDIHLNDLYTRYRQ 76
            :|...:||    |.:|....|.|......|:.|...|         ...|.....|.:||..:.:
  Rat   467 IIENLEGN----KHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNK 527

  Fly    77 RLRKSLFR-SGLLTS------LLACVVS--------IIIGIVYG------QHLVQTMLL------ 114
            ....:::. ..||||      ||.|:..        .|:.|.|.      ..::.::.|
  Rat   528 LTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLMVG 592

  Fly   115 -----VLAALISGSILTAL--------QFPAVLSSPAAALAFAIVTTFSLGTI-AAITGDELAPL 165
                 ||.||:....|..|        :.|..|.|.|..|.:...:..||.:: :|..|:|
  Rat   593 HNHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEE---- 653

  Fly   166 PMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFG----EIVMLASASV 226
                             .:||:..|::|...:..:.         :|:|.|    .::.||:..:
  Rat   654 -----------------SLSVLQLLYLTNNLLTDQC---------IPVLVGHPHLRVLHLANNQL 692

  Fly   227 SGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLS-----VIPAYIAAEVKRSIMLK 286
                          :|...::..     ||    ||.|:|.||     .||..||
  Rat   693 --------------QTFPASKLN-----KL----EQLEELNLSGNKLKAIPTTIA---------- 724

  Fly   287 MADACQRAGGQASTSATRFHELHVQRHTNVTILFADI-----VNFTPLSSS-----LTASDLVKT 341
                          :..|.|.|  ..|.|...:|.:|     :.|..||.:     |....|..|
  Rat   725 --------------NCKRLHTL--VAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPETLPAT 773

  Fly   342 LNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPI-SRPQHATNCV------NMGLQMIDAIRHV 399
            |.||    |.....|..|..|.| |.:..::.|.| .:|...|:..      :.||..:...|:.
  Rat   774 LQDL----DLTGNTNLVLEHKTL-DMFSHITTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNK 833

  Fly   400 REATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSD--------------DVTLANHMESGGVAG 450
            ...:.:.:|        |...|| |.....||  .|              ||.|....
  Rat   834 LCVSALAMD--------NFAEGV-GAVYGMFD--GDRNEELPRLLQCTMADVLLEEVQ------- 880

  Fly   451 RVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYL---IVPPKPAYTYSVPRVVECIE--- 509
              |.|..|: |:.:.|.|...:.|.....|....:..|:   ...|..:::.:|..|..|..
  Rat   881 --HSTSDTV-FMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGTCQAVLC 942

  Fly   510 --------------QNDPSPTTEETKEIKETDQSHEATDVADV--------LLPVTVAPPPAIVD 552
                          ::||    ||.:.:|  ||....|:...|        :|..|...|..:..
  Rat   943 RGGKPVPLSKVFSLEHDP----EEAQRVK--DQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPK 1001

  Fly   553 EKMSPTSINSQE---------------------APLHAPLASAASMSIKELSEEEDEADEATAVT 596
            ..:|.|.:..|:                     |..|.....||:..:..|::.....|...|:.
  Rat  1002 PHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMV 1066

  Fly   597 EPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQ 661
            ..|...::....:....|..|..|...:|..:...|....|                |:||..::
  Rat  1067 VYLNIGEEGCTCEMHGLALPGPVGFASTATIKDAPKPTTPS----------------SSSGIASE 1115

  Fly   662 SSNPASVTPTAAAPAGGAASN-----SLTVAEAPERSRR-----------------------KLS 698
            .|:..| |...::..|..||:     .|..:..|...||                       ..|
  Rat  1116 LSSEVS-TSEVSSEVGSTASDEHNTVGLETSLLPRPERRCSLHPVPSAGTFQRQPSCATFSSNQS 1179

  Fly   699 VQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVEC---------WGA 754
            ..||.| .|.:...|....|.::.:.  .......|..:.|.|:........|         :|.
  Rat  1180 DNGLDS-DDDQPVEGVITNGSRVEVE--VDIHCCRGRESENSPTLPKNSSYPCSEEHARGLGFGI 1241

  Fly   755 DR----------------------PFANIAESKLVKNIGLA----SIAMIESNLLPPERKCFNFN 793
            .|                      |..:....|.:.|..:.    |:.:||.....|:||.   .
  Rat  1242 RRQNSVNSGILLPVNKDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKT---G 1303

  Fly   794 FFGPPTELKP 803
            :|..||:|:|
  Rat  1304 YFAAPTQLEP 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	52/271 (19%)
		CYCc	259..467	CDD:214485	54/243 (22%)
		Guanylate_cyc	311..469	CDD:278633	42/188 (22%)
		BASP1	510..667	CDD:283191	33/185 (18%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131
		PLN00113	284..>762	CDD:215061	73/377 (19%)
		leucine-rich repeat	289..309	CDD:275380
		leucine-rich repeat	310..336	CDD:275380
		leucine-rich repeat	337..359	CDD:275380
		leucine-rich repeat	360..382	CDD:275380
		leucine-rich repeat	383..405	CDD:275380
		leucine-rich repeat	406..428	CDD:275380
		leucine-rich repeat	429..452	CDD:275380
		leucine-rich repeat	453..476	CDD:275380	3/12 (25%)
		leucine-rich repeat	477..497	CDD:275380	5/19 (26%)
		leucine-rich repeat	498..517	CDD:275380	2/18 (11%)
		leucine-rich repeat	518..539	CDD:275380	3/20 (15%)
		leucine-rich repeat	540..562	CDD:275380	6/21 (29%)
		leucine-rich repeat	563..584	CDD:275380	3/20 (15%)
		leucine-rich repeat	586..607	CDD:275380	5/20 (25%)
		leucine-rich repeat	608..631	CDD:275380	6/22 (27%)
		leucine-rich repeat	632..681	CDD:275380	13/78 (17%)
		leucine-rich repeat	682..705	CDD:275380	5/45 (11%)
		leucine-rich repeat	706..728	CDD:275380	8/45 (18%)
		leucine-rich repeat	751..772	CDD:275380	5/20 (25%)
		PP2Cc	820..1069	CDD:238083	49/275 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900