Protein Alignment Ac76E and AgaP_AGAP009315

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_001230685.2
• Gene: AgaP_AGAP009315 / 4578014
• VectorBaseID: AGAP009315
• Length: 1157
• Species: Anopheles gambiae
• Alignment Length: 1352
• Identity: 394/1352 - (29%)
• Similarity: 608/1352 - (44%)
• Gaps: 356/1352 - (26%)

  Fly    33 KAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVS 97
            :.::::...|:..::.::........|....|..|:.||..|..:.::..|...|:.|:|..|.:
Mosquito    20 RKISTNQHTMDGTMATTVGINQSGTGGVLLPDAVLDKLYQSYALKQKRVAFACYLIASILFDVWA 84

  Fly    98 IIIGIVYGQHLVQTMLLVLAALISGSILTAL--------QFPAVLSSPAAALAFAI------VTT 148
              |.:..||.:  ..::|.:..::.:|:.|:        :|..|:...|..||:.:      :..
Mosquito    85 --IAVPQGQSV--ESIVVTSVFLTINIVLAIVLRFCGRGRFRGVIWEIAPHLAWLLAIKQLFLQL 145

  Fly   149 FSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPV-----SVVLAL--FMTAIHIVYRIGTSPD 206
            |..|::        .|.......:.::.::.::.||     .::|.|  |.|.::.:..:....:
Mosquito   146 FLKGSV--------TPRDSLGWAVLLNFLVYVTLPVLLKYTGILLGLGSFATYVNAIIGLAKKEN 202

  Fly   207 YAPNLPMLFGE-----IVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQL 266
            |       |.|     |::|.:|::.||....:::|...|.....:.|:|.::.:|.:..:||:|
Mosquito   203 Y-------FWEQQVANILLLIAATLIGLLCYFLAEAKQRRAFLEAKQGLEVKMLIEEQSAEQERL 260

  Fly   267 LLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSS 331
            ||||:|.::|.::::.:              .||::.:|.::::.||.||:||:||||.||.:||
Mosquito   261 LLSVLPEHVAVKMRQDL--------------GSTNSEQFKKIYMSRHENVSILYADIVGFTAISS 311

  Fly   332 SLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAI 396
            :.:|.||||.||:||.|||::|::.|.||||||||||||:||.|:.||.||..||:|||.|:.||
Mosquito   312 TYSAQDLVKILNELFARFDRLAEKYQQLRIKILGDCYYCISGAPVERPDHAVLCVHMGLSMVKAI 376

  Fly   397 RHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDF 461
            ::|::.|...||||:|||||.||.|:||.|:|||||:|.||.|||.|||.|.|||||::::||.|
Mosquito   377 KYVQQKTNSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHLSEKTLGF 441

  Fly   462 LGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKET 526
            |..:||||...|..|:..|....:::|.|                             ||.:|..
Mosquito   442 LNGEFEVEPAFGEKREEALRIAGLKTYFI-----------------------------TKVLKPF 477

  Fly   527 DQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDE--- 588
            ..|......||         |..:|.|...|:.|                     |.|::|:
Mosquito   478 CPSEHKNGSAD---------PKDVVIEPDGPSEI---------------------LREDDDDTKV 512

  Fly   589 ----ADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGD---SAASESVAKSAALSLPADDLLSM 646
                |:.|.|..||    ...|.:||........:.|.|   ....|.|::.....:..|..:.:
Mosquito   513 GMPPANGANAGDEP----STPGTDDKTDPLEDDTQASEDYKMRLRKELVSRDGHSEISKDTTIFL 573

  Fly   647 SGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRS 711
            :.::.  ::..|..:...|.|..|..||                      |.||
Mosquito   574 TFNDK--THETAYNEYREPHSAVPLLAA----------------------LLVQ----------- 603

  Fly   712 SGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIA 776
                                                          |..|..:.||
Mosquito   604 ----------------------------------------------FVAILYALLV--------- 613

  Fly   777 MIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVL-FLSLA 840
                  ||  |...:|....||                              |:..||: |:|:|
Mosquito   614 ------LP--RTAVHFEIVIPP------------------------------LVIIFVMVFISVA 640

  Fly   841 VVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRY-----LRL 900
                       ..|..:|.:|::|                            .|.||     ||.
Mosquito   641 -----------ESLTGILPAFITL----------------------------NSKRYNDSTSLRK 666

  Fly   901 AMFVVVNIL-----ISSCAVFSV---------------INYTVPDGVSKEPSSNQTILESNFSSV 945
            :..:::.:|     :|....|.:               |:...|....|..:|::|.|..|.::|
Mosquito   667 STAIIIVLLLGVSNVSDMGFFFICFWSFRYFLVAIEIKIDTKSPKKSCKLAASHRTPLSLNITNV 731

  Fly   946 -FVNSTLEDVQLWEIDYAIPIAPVFL--YCCAISLAAISAFLRSGFILKLIAMLV--AVIAQVTV 1005
             |.::.:|..       ::.:.|.:.  |...| |.|.|...:...:.|::.|::  |:...|.:
Mosquito   732 SFASTEMEPA-------SVCLFPSYFSNYTVLI-LIATSIITQLSHLSKILLMIIITAIHCYVNI 788

  Fly  1006 LGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVE 1070
            ....:.|. ..|..|.:..||......||:.:.:.|..|.|..:.|.|..|:||.::..::|:..
Mosquito   789 FHLDEAFR-NEDFGIMNVFPLRYTLSALLVAVTIALSFLARHIDKVDRVIFMWKTEVIDQKEKAS 852

  Fly  1071 TMRGINKILLENILPAHVATHFL-HLERS-TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGL 1133
            .||..|:.|:.|:||.|||.||: :.:|| .:||.:||:.|.|:|||:||:.:||.|..||.|||
Mosquito   853 DMRRRNEALVYNVLPMHVAEHFMGNRKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGL 917

  Fly  1134 ECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPG---KEDGATSRSFADEKRTEE 1195
            ||||.|||:|.|||.||..|:|..|.|||||.||||.||||.|.   |.|...|..:|
Mosquito   918 ECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGLNPSRIVKPDDPVSVRWA------- 975

  Fly  1196 HNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMD 1260
             ::.:|||||:.|...|..||.:||..|.|::|:||||:.||||||:||.||||.|||||||||:
Mosquito   976 -HLALLVEFALELKKALQGINEQSFNHFVLKMGVNHGPITAGVIGARKPHYDIWGNTVNVASRME 1039

  Fly  1261 SCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL 1312
            |.|..|.:|.||.|.:||.|.||..|.|||..|||||.|:||:::    ||:
Mosquito  1040 STGKAGAIQVTEETCQILQTFGYTFEQRGLVAVKGKGQLMTYYLQ----GKV 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	51/247 (21%)
		CYCc	259..467	CDD:214485	108/207 (52%)
		Guanylate_cyc	311..469	CDD:278633	98/157 (62%)
		BASP1	510..667	CDD:283191	29/166 (17%)
		CYCc	1079..1283	CDD:214485	113/208 (54%)
		Guanylate_cyc	1101..1305	CDD:278633	116/206 (56%)
AgaP_AGAP009315	XP_001230685.2	AC_N	<49..284	CDD:292831	54/267 (20%)
		CYCc	250..447	CDD:214485	109/210 (52%)
		Guanylate_cyc	288..470	CDD:278633	104/181 (57%)
		CYCc	853..1065	CDD:214485	118/219 (54%)
		Guanylate_cyc	885..1085	CDD:278633	116/211 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820