DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and AgaP_AGAP000214

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_310920.4	Gene:	AgaP_AGAP000214 / 4576149	VectorBaseID:	AGAP000214	Length:	754	Species:	Anopheles gambiae

Alignment Length:	785	Identity:	157/785 - (20%)
Similarity:	275/785 - (35%)	Gaps:	249/785 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 IVDEKMSPTSINSQEAPLHAPLASAASM----------SIKELSEEEDEADEATAVTE----PLM 600
            |:..|..|....:::|....|:|:.|:.          ||.|:.:.........||.|    .|.
Mosquito   163 IIRRKGDPVEPEAKKATAEPPVANTATAAAAATPKARHSIPEVVKSVPITSLDPAVPELANLGLC 227

  Fly   601 HRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNS----GAQAQ 661
            .|....|.....|:|...:...|::||....|           ||:|.|::| |||    |..::
Mosquito   228 KRILASKTYATSKSNSALKQPTDTSASSHGNK-----------LSISSSQNG-SNSIPLCGEVSK 280

  Fly   662 SSNPASVT--PTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIH 724
            :|...:..  .::::.:||.|.|      .||..::  ..:|..:.|..|.....|:
Mosquito   281 ASKDTNTNCDSSSSSSSGGPARN------GPEWQQK--GPKGPGTTAVERSDHFQFL-------- 329

  Fly   725 SGESFRSHAGHVTRNRPSSKMTKYVEC-WGADRP------FANIAESKLV--KNIGLASIAMIES 780
                ....:|..|..|.|.:..:...| ..|..|      |..|....|:  :|:.:.......|
Mosquito   330 ----ITEISGPKTPTRRSDEKDQQAVCQLVAKEPMISPMTFCKIFPFHLMFDRNMHIVQAGRSVS 390

  Fly   781 NLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRA-QPDTHFRFDLICAFVLFLSLAVVQL 844
            .::|                    .::.:|.|..|::.| :|.....|:.|.|
Mosquito   391 RVIP--------------------RIYEKNCPLLALFEAVRPHLQLSFENILA------------ 423

  Fly   845 IVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHAST--TERNGPGQVVASSRYLRLAMFVVVN 907
                                              |.:|  ..:...|.:..|.|||||.
Mosquito   424 ----------------------------------HINTIYVLKTKAGVMSKSERYLRLK------ 448

  Fly   908 ILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYC 972
                                                             .::.| ||.:.:.|:.
Mosquito   449 -------------------------------------------------GQMMY-IPGSDLILFQ 463

  Fly   973 CAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVI 1037
            |..|:..:....:.|..:..|.:..|  ::..|| .|:.||.  :..:|..|.:
Mosquito   464 CYPSVMNLDDLTKKGLHISDIPLHDA--SRDLVL-LSEKFEA--EYKLTTNLEI----------- 512

  Fly  1038 ILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELY 1102
                           .||.|.:....:|.|:.:|.|     ||.::||..||....|   ...:.
Mosquito   513 ---------------LTDRLQQTYRDLESEKQKTDR-----LLYSVLPKTVANELRH---QRPVA 554

  Fly  1103 HESYSCVAVMFASIPNYKEFYDETDVNKQG-LECLRLLNEIICDFDKLLLKPKFSGIEKIKTIAS 1166
            .:.|..|.:||:.|..:.: |...:.:.:| ::.:::|||:...||:|......|.|.|::|:..
Mosquito   555 PKRYDSVTLMFSGIVGFGQ-YCAANTDPEGAMKIVKMLNELYTIFDELTDSKSNSNIYKVETVGD 618

  Fly  1167 TYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNH 1231
            .||..|||             .||.   |::...:...|:.::.:..::...: :..::.||::.
Mosquito   619 KYMAVSGL-------------PDEC---ENHAKCIARLALDMLDMAKNVMMGT-EAMKITIGIHS 666

  Fly  1232 GPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILM-----TAGYECECRGLT 1291
            |.|:.||||.:.|:|.::.||||:.||.::.||.|.:..:|.|.|:|.     ...:..|.||..
Mosquito   667 GEVVTGVIGNRMPRYCLFGNTVNLTSRTETTGVPGHINISETTYKLLCDPVNHDPSFNLEYRGPV 731

  Fly  1292 YVKGK 1296
            .:|||
Mosquito   732 VMKGK 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191	32/134 (24%)
		CYCc	1079..1283	CDD:214485	56/209 (27%)
		Guanylate_cyc	1101..1305	CDD:278633	55/202 (27%)
AgaP_AGAP000214	XP_310920.4	HNOB	1..163	CDD:285002	157/785 (20%)
		HNOBA	361..547	CDD:285003	52/343 (15%)
		CYCc	527..713	CDD:214485	58/211 (27%)
		Guanylate_cyc	553..745	CDD:278633	55/202 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810