DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1280	Identity:	400/1280 - (31%)
Similarity:	593/1280 - (46%)	Gaps:	300/1280 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGL-LTSLLACVVSI---------IIGIVYGQHLVQTMLLVLAALIS 121
            |..|:..|..||.::.....| :.||||..:::         ..|:..|.|.|..:|.:  ||..
Mouse    44 LEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFL--ALFV 106

  Fly   122 GSILTALQFPAVLSSPAAALAFAIV-----TTFSLG-----TIAAITGDELAPLPMYALFLCI-- 174
            .:.:.:||...:......||.|::.     ..|:||     :.....|..:|...::.|.|..
Mouse   107 VTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFV 171

  Fly   175 -HSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFG-EIVMLASASVSGLYYRIMSDA 237
             :::||:...:::...|.:.|.|::......|...|.|....| ..::....::.|::.||:::.
Mouse   172 SYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTER 236

  Fly   238 AHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSA 302
            :..:.....|..||.|::||.|.|:||:||:|::|..:|.|:|.. .||..:..
Mouse   237 SQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED-FLKPPERI----------- 289

  Fly   303 TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDC 367
              ||::::|||.||:|||||||.||.|:|..||.:|||.||:|||:||::|.||.|.||||||||
Mouse   290 --FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDC 352

  Fly   368 YYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDV 432
            |||||||...:..||..||.|||.|||.|..|.|||.::::||:|:|||.||||||||||||:||
Mouse   353 YYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV 417

  Fly   433 WSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAY 497
            ||:||||||.||:.|:.|:|||||.||..|...:|||.|.|..|:.:|..|.:|::.|||
Mouse   418 WSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVP----- 477

  Fly   498 TYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINS 562
                                           ||.                     .|:.|..|.|
Mouse   478 -------------------------------SHR---------------------RKIFPGLILS 490

  Fly   563 QEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAAS 627
            ...|       |..|..|.:          ..:...|||
Mouse   491 DIKP-------AKRMKFKTV----------CYLLVQLMH-------------------------- 512

  Fly   628 ESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPER 692
              ..|.....:|                                        .||.:|..:..:|
Mouse   513 --CRKMFKAEIP----------------------------------------FSNVMTCEDDDKR 535

  Fly   693 SRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRP 757
            ...:.:.:.|     |.||                ||.::..:.|   |.:::.:|:.
Mouse   536 RALRTASEKL-----RNRS----------------SFSTNVVYTT---PGTRVNRYIS------- 569

  Fly   758 FANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPD 822
                              .::|:.....|....||           ||:.|::..||..|....|
Mouse   570 ------------------RLLEARQTELEMADLNF-----------FTLKYKHVEREQKYHQLQD 605

  Fly   823 THFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS---FVSLALFLYLSNMSVPDVHASTTE 884
            .:|...::.|.:|.....::.|:||..::|:|..|:.|   .|:..|:|:::.:..
Mouse   606 EYFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQC--------- 661

  Fly   885 RNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNS 949
              .||.:...   :|.|:.|.:.:||.|.|...|:. .:|...|.:.:|:..:|.:.....
Mouse   662 --FPGCLTIQ---IRTALCVFIVVLIYSVAQGCVVG-CLPWAWSSQSNSSLVVLAAGGRRT---- 716

  Fly   950 TLEDVQLWEIDYAIPIAPV-----FLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVL--- 1006
                        .:|..|.     .|.||.:....::.|||...:.|:|.:.....:.:.||
Mouse   717 ------------VLPALPCESAHHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELS 769

  Fly  1007 GYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVET 1071
            ||:.:     ......|...|....:||....|.||.  ||.:...|.|:||.|:.:.|::::|.
Mouse   770 GYTKV-----GGGALSGRSYEPIMAILLFSCTLALHA--RQVDVRLRLDYLWAAQAEEERDDMER 827

  Fly  1072 MRGINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLEC 1135
            ::..||.:|.|:||||||.|||... |:.:||::|||.|.||||||||:.:||.|.|.|..|:||
Mouse   828 VKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC 892

  Fly  1136 LRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVI 1200
            ||||||||.|||:|:.|..:..:||||||.||||.|.||.|    .|.:|:    |::...::..
Mouse   893 LRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAP----TAGTRA----KKSISSHLCT 949

  Fly  1201 LVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVM 1265
            |.:|||.:..:||.||.:|:..|.||:|:|.|||:||||||::||||||.|||||||||||.||.
Mouse   950 LADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1014

  Fly  1266 GRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            ||:|.||...::|....|:..|||...|||||.::|||::...||
Mouse  1015 GRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDG 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	60/245 (24%)
		CYCc	259..467	CDD:214485	117/207 (57%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	15/156 (10%)
		CYCc	1079..1283	CDD:214485	112/204 (55%)
		Guanylate_cyc	1101..1305	CDD:278633	112/203 (55%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	34/146 (23%)
		CYCc	257..452	CDD:214485	117/208 (56%)
		Guanylate_cyc	293..475	CDD:278633	111/181 (61%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		8/71 (11%)
		CYCc	825..1036	CDD:214485	116/218 (53%)
		Guanylate_cyc	858..1055	CDD:278633	112/204 (55%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710