Protein Alignment Ac76E and Adcy1

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_033752.1
• Gene: Adcy1 / 432530
• MGIID: 99677
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1280
• Identity: 400/1280 - (31%)
• Similarity: 593/1280 - (46%)
• Gaps: 300/1280 - (23%)

  Fly    67 LNDLYTRYRQRLRKSLFRSGL-LTSLLACVVSI---------IIGIVYGQHLVQTMLLVLAALIS 121
            |..|:..|..||.::.....| :.||||..:::         ..|:..|.|.|..:|.:  ||..
Mouse    44 LEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFL--ALFV 106

  Fly   122 GSILTALQFPAVLSSPAAALAFAIV-----TTFSLG-----TIAAITGDELAPLPMYALFLCI-- 174
            .:.:.:||...:......||.|::.     ..|:||     :.....|..:|...::.|.|..
Mouse   107 VTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFV 171

  Fly   175 -HSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFG-EIVMLASASVSGLYYRIMSDA 237
             :::||:...:::...|.:.|.|::......|...|.|....| ..::....::.|::.||:::.
Mouse   172 SYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTER 236

  Fly   238 AHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSA 302
            :..:.....|..||.|::||.|.|:||:||:|::|..:|.|:|.. .||..:..
Mouse   237 SQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED-FLKPPERI----------- 289

  Fly   303 TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDC 367
              ||::::|||.||:|||||||.||.|:|..||.:|||.||:|||:||::|.||.|.||||||||
Mouse   290 --FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDC 352

  Fly   368 YYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDV 432
            |||||||...:..||..||.|||.|||.|..|.|||.::::||:|:|||.||||||||||||:||
Mouse   353 YYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV 417

  Fly   433 WSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAY 497
            ||:||||||.||:.|:.|:|||||.||..|...:|||.|.|..|:.:|..|.:|::.|||
Mouse   418 WSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVP----- 477

  Fly   498 TYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINS 562
                                           ||.                     .|:.|..|.|
Mouse   478 -------------------------------SHR---------------------RKIFPGLILS 490

  Fly   563 QEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAAS 627
            ...|       |..|..|.:          ..:...|||
Mouse   491 DIKP-------AKRMKFKTV----------CYLLVQLMH-------------------------- 512

  Fly   628 ESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPER 692
              ..|.....:|                                        .||.:|..:..:|
Mouse   513 --CRKMFKAEIP----------------------------------------FSNVMTCEDDDKR 535

  Fly   693 SRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRP 757
            ...:.:.:.|     |.||                ||.::..:.|   |.:::.:|:.
Mouse   536 RALRTASEKL-----RNRS----------------SFSTNVVYTT---PGTRVNRYIS------- 569

  Fly   758 FANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPD 822
                              .::|:.....|....||           ||:.|::..||..|....|
Mouse   570 ------------------RLLEARQTELEMADLNF-----------FTLKYKHVEREQKYHQLQD 605

  Fly   823 THFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS---FVSLALFLYLSNMSVPDVHASTTE 884
            .:|...::.|.:|.....::.|:||..::|:|..|:.|   .|:..|:|:::.:..
Mouse   606 EYFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQC--------- 661

  Fly   885 RNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNS 949
              .||.:...   :|.|:.|.:.:||.|.|...|:. .:|...|.:.:|:..:|.:.....
Mouse   662 --FPGCLTIQ---IRTALCVFIVVLIYSVAQGCVVG-CLPWAWSSQSNSSLVVLAAGGRRT---- 716

  Fly   950 TLEDVQLWEIDYAIPIAPV-----FLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVL--- 1006
                        .:|..|.     .|.||.:....::.|||...:.|:|.:.....:.:.||
Mouse   717 ------------VLPALPCESAHHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELS 769

  Fly  1007 GYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVET 1071
            ||:.:     ......|...|....:||....|.||.  ||.:...|.|:||.|:.:.|::::|.
Mouse   770 GYTKV-----GGGALSGRSYEPIMAILLFSCTLALHA--RQVDVRLRLDYLWAAQAEEERDDMER 827

  Fly  1072 MRGINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLEC 1135
            ::..||.:|.|:||||||.|||... |:.:||::|||.|.||||||||:.:||.|.|.|..|:||
Mouse   828 VKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC 892

  Fly  1136 LRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVI 1200
            ||||||||.|||:|:.|..:..:||||||.||||.|.||.|    .|.:|:    |::...::..
Mouse   893 LRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAP----TAGTRA----KKSISSHLCT 949

  Fly  1201 LVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVM 1265
            |.:|||.:..:||.||.:|:..|.||:|:|.|||:||||||::||||||.|||||||||||.||.
Mouse   950 LADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1014

  Fly  1266 GRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            ||:|.||...::|....|:..|||...|||||.::|||::...||
Mouse  1015 GRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDG 1059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	164/421 (39%)
		Guanylate_cyc	310..469	CDD:425528	103/158 (65%)
		Guanylate_cyc	1101..1305	CDD:425528	112/203 (55%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		AcyC	99..455	CDD:441717	152/371 (41%)
		Guanylate_cyc	293..475	CDD:425528	111/181 (61%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		8/71 (11%)
		Guanylate_cyc	858..1055	CDD:425528	112/204 (55%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1079..1118