DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gyc89Db

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	304	Identity:	78/304 - (25%)
Similarity:	137/304 - (45%)	Gaps:	67/304 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1016 NDANITHGLPLEI--KGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKI 1078
            ||.| .|||..|:  .|:                 ::.::.:.:::   |.||...|..:.:...
  Fly   413 NDLN-PHGLSRELVMAGW-----------------QHCSKLEIMFE---KEEQRSDELEKSLELA 456

  Fly  1079 ---------LLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQ-GL 1133
                     ||.:::|..:|.   .:.:|.|...:|:..|:|:|..:.|   .||....|.| .:
  Fly   457 DSWKRQGDELLYSMIPRPIAE---RMRKSEEHVCQSFEEVSVIFIEVMN---IYDSGSNNIQDAM 515

  Fly  1134 ECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASG---LRPGKEDGATSRSFADEKRTEE 1195
            :.:..||::....|:.::.|   .:.|::|:...||..||   :.|...:.|...:....|:.:.
  Fly   516 QAVTTLNKVFSALDEEIISP---FVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMKKVKA 577

  Fly  1196 HNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMD 1260
            |          ||..:            .:|:|:|.|||:|||:|.:.|:|.::.:|||.||||:
  Fly   578 H----------ALPGV------------AIRVGINSGPVVAGVVGMKVPRYCLFGDTVNTASRME 620

  Fly  1261 SCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFV 1304
            |......:|.:..||..:...||:.|.||...|||||.:.||::
  Fly   621 SSSDPWMIQLSNYTALKVQKVGYKVEARGFVKVKGKGEMETYWL 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831
		CYCc	259..467	CDD:214485
		Guanylate_cyc	311..469	CDD:278633
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485	54/207 (26%)
		Guanylate_cyc	1101..1305	CDD:278633	60/208 (29%)
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	16/89 (18%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	60/205 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740