DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gyc88E

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	173/776 - (22%)
Similarity:	290/776 - (37%)	Gaps:	239/776 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IVYGQHLV-----QTMLLVLAALISGSI---------LTALQFPAVLSSPAAALAFAIVTTFSLG 152
            :|:|..:|     .:::::|..|:...|         |.|.:|..:|:...        ..|.|.
  Fly   216 MVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTN--------NIFELV 272

  Fly   153 TIAAIT------GDELAPLPMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPD----- 206
            |:..:|      .::|                                  :.:..|:.|:
  Fly   273 TVDPVTERFDVQNEDL----------------------------------LQHEDGSEPEKSLRL 303

  Fly   207 -----YAPN--LPMLFGEIVM--LASASVSGLYYRIMS--DAAHNRTVDGTRTGIEQRVKLECER 260
                 |..|  :.|..|..||  |.|...:|||...:|  |.:.:..:.||:..:|  :||..::
  Fly   304 KGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLALDQ 366

  Fly   261 EQQEQLLLSVIPAYIAAEVKRS-------IMLKMADACQRAGGQASTSATRFHELHVQRHTNVTI 318
            |||:...|......:..|::|:       |..::||..:|......|         .:...:|:|
  Fly   367 EQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDT---------CEMFDSVSI 422

  Fly   319 LFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHAT 383
            ||:|||.||.:.|.:|..::|..||.::..||::.:.|...:::.:||.|..|:|.|.....||.
  Fly   423 LFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAE 487

  Fly   384 NCVNMGLQMIDAIRHVRE-ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGG 447
            ...:|.|.|:|||..::: :||.::.:|:|:|:|.|:.|::||:..::.::.|.|..|:.|||..
  Fly   488 RVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTS 552

  Fly   448 VAGRVHITKQTLDFLGDKFE-VEQGE-----GGNRDAYLADHK-------------VESYLIVPP 493
            :|.:|||::.|...:|..:: :|:||     .|....|..:.:             |.....|||
  Fly   553 IAMKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQVHPLSPVPP 617

  Fly   494 KPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPP----PAIVDEK 554
            .|                     |.:||.|. ...|...|.:..|.:.:..:.|    || ||..
  Fly   618 TP---------------------TPKTKAIM-PPVSKPLTPMMPVSVSLAASMPTSNVPA-VDVM 659

  Fly   555 MSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHR 619
            .|.:||:.    |....|:||.||:      ..:|..|.|:|
  Fly   660 ASSSSISG----LALTAAAAAHMSL------HHQAVVAEALT----------------------- 691

  Fly   620 GSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSL 684
            |:....|..|||               ||:....:..||.:...|....:|.......     ..
  Fly   692 GASVEVALPSVA---------------SGATGAAAGGGAPSDDRNSRIYSPVTFKDVA-----RR 736

  Fly   685 TVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYV 749
            :||.:|.||..:..       .:|||                ||..:..|||....||
  Fly   737 SVANSPVRSCAQPD-------QERRR----------------ESRSNSTGHVFMRTPS------- 771

  Fly   750 ECWGA----DRPF---ANIAESKLVKN------IGLASIAMIESNLLPPERKCFNFNFFGP 797
            |.:|:    ...|   ..|:.|.|..|      .|.:..........||:.:..|.:.|.|
  Fly   772 EIFGSLILDTEEFLEDLQISRSSLANNNNNQSPCGFSPTPPFRIGSAPPKPRPSNPDKFTP 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	42/229 (18%)
		CYCc	259..467	CDD:214485	64/215 (30%)
		Guanylate_cyc	311..469	CDD:278633	53/159 (33%)
		BASP1	510..667	CDD:283191	35/160 (22%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	44/231 (19%)
		CYCc	383..571	CDD:214485	60/196 (31%)
		Herpes_ICP4_C	794..>955	CDD:332854	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454055
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740