DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and ACXD

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster

Alignment Length:	1434	Identity:	366/1434 - (25%)
Similarity:	560/1434 - (39%)	Gaps:	465/1434 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SAARMNDALSASLADLSEQENGTTAE-------------DIHLNDLYTRYRQRLRKSLFRSGLLT 89
            ||...|.:...|||..|.|......|             ::.|.|.|..|.:||     |.|.|:
  Fly     7 SAIEYNRSNPISLARTSSQAQTVQNEKNWEWSYLVRKCRNLELEDSYDLYMRRL-----RVGYLS 66

  Fly    90 SLLACVVSIIIGIVYGQHLVQTMLL------------VLAALISGSIL---TALQFPAVLSS--- 136
            ..:...|::.:        :.|:||            ::|.:.||.::   ..:.|.:.|.|
  Fly    67 LFIFIHVAVTV--------IHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHG 123

  Fly   137 ----PAAALAFAIVTTFSLGT---IAAITGDELAPL----PMYALFLCIHSMLPISWPVSVVLAL 190
                ..:.||..::....:|.   .|....|.|.|:    .:||:::.:        ||..:|..
  Fly   124 WVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFM--------PVPYLLQP 180

  Fly   191 FM--TAIHIVYRIG-----TSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRT 248
            |:  :|:...|.|.     |:.| ...:..:..|.:.|:..::.|:::|:|.|.|...|....|.
  Fly   181 FVLGSAVTFCYIINYSFVITAKD-DNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQ 244

  Fly   249 GIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHE------ 307
            .:|:.:.|...|:|:..||||::||.||..::..:..::..:.|:...|:.....|..:
  Fly   245 YVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKR 309

  Fly   308 --------LHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKIL 364
                    |.::.|.:||:|:||:||:|.|:::|....||:.|:|||.|||..::|...||||.|
  Fly   310 WRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFL 374

  Fly   365 GDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQ 429
            |||||||:||......||..||::||:||..||.|||...:|:|||||:|:|:||.||:|..|||
  Fly   375 GDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQ 439

  Fly   430 FDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQG-EGGNRDAYLADHKVESYLIVPP 493
            ||:||.||.:||.:|:.|..||||::::||..|..::..|.| |....|..|..|.:.::|
  Fly   440 FDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFL---- 500

  Fly   494 KPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPT 558

  Fly   501 ----------------------------------------------------------------- 500

  Fly   559 SINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGD 623
             |.|..||:|.|........:|:|||..                          |||..|
  Fly   501 -IKSLRAPMHDPRRRMRERQVKKLSEAS--------------------------KANFMH----- 533

  Fly   624 SAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAE 688
                                                                      ||
  Fly   534 ----------------------------------------------------------NS----- 535

  Fly   689 APERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWG 753
                                             ::|.....|:.|             |...|..
  Fly   536 ---------------------------------TLHQYNQVRNQA-------------KLEMCRE 554

  Fly   754 ADR-PFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMY 817
            .|: |...|..:|:.:.    |..:.:..:   |.:.|..|       :....:::|....|..|
  Fly   555 LDKMPIGRIQLTKVFRR----STRLTQDEI---EEETFRRN-------ISSCCLFFRIRNWEFQY 605

  Fly   818 RAQPDTHFRFDLICAFVLFLSLAVVQLI----------VIELNLALLGSLLASFVSLALFLYLSN 872
            ..:||...::.:..|:|:::.|..:||:          :....:.||..||  .||....|::..
  Fly   606 IKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLL--IVSWYKKLWIMY 668

  Fly   873 MSVPDVHASTTERNGPGQVVASSRYLRLAMF-----------VVVNILISSCAVFSVINYTVPDG 926
            ||..||    :..||           ||:.|           ||:.:::....:||.....:...
  Fly   669 MSDADV----SSPNG-----------RLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQV 718

  Fly   927 VSKEPSSNQTILESNFSSVFVNSTLEDVQL---WEIDYAIPIAPVFLYCCAISLAAISAFLRSGF 988
            |......:...|:..:.        |.||.   |          :...|..:.:.....|.|..|
  Fly   719 VGCSSDEDYADLDPTYD--------ERVQCFHPW----------ILTNCMTLVIGMSFLFTRIPF 765

  Fly   989 ILKLIAMLVAVIAQVTVLGYSDL------FEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQ 1047
            |:|      :..:.:.::||:.|      |...|..:.......:....||:::...:.|.::||
  Fly   766 IIK------SCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHILLMIITFGIFHLMERQ 824

  Fly  1048 GEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVM 1112
            .|::|:.|:.||.:|..:||:........|:||.||||.|||..:|..:...|||:|.|..||||
  Fly   825 TEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQNELYYEEYDNVAVM 889

  Fly  1113 FASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFS-GIEKIKTIASTYMCASGL-- 1174
            ||||.|:       |.:|.|   ||:|||||||||.:|.|...| .:||||....|||.|.||
  Fly   890 FASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDV 944

  Fly  1175 ----------------------RPGKEDGATSRSFAD-------------------EKRTEEHNV 1198
                                  |..:.|||.| |.||                   |:...|.||
  Fly   945 SRSEQVNAPQMKFRNVSLMPNGRRSRYDGARS-SNADGVQRVPYGNGSNIALDLDLERGQYEGNV 1008

  Fly  1199 V--------------------ILVEFAIALMSILDSINRESFQR--------FRLRIGLNHGPVI 1235
            :                    ::.|||:.||..:...|.|:.|.        ..||||::||..:
  Fly  1009 ITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAM 1073

  Fly  1236 AGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLV 1300
            |||:|..||.||||.|.||:||||||.||.|::|.|||||..|.....:|..||:|:|||:||:.
  Fly  1074 AGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIP 1138

  Fly  1301 TYFV 1304
            ||.:
  Fly  1139 TYII 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	58/257 (23%)
		CYCc	259..467	CDD:214485	95/221 (43%)
		Guanylate_cyc	311..469	CDD:278633	81/157 (52%)
		BASP1	510..667	CDD:283191	14/156 (9%)
		CYCc	1079..1283	CDD:214485	106/275 (39%)
		Guanylate_cyc	1101..1305	CDD:278633	106/276 (38%)
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	58/263 (22%)
		CYCc	254..476	CDD:214485	95/221 (43%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	89/251 (35%)
		CYCc	856..1117	CDD:214485	105/271 (39%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	106/274 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850