Protein Alignment Ac76E and Ac3

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Alignment Length: 1380
• Identity: 421/1380 - (30%)
• Similarity: 615/1380 - (44%)
• Gaps: 374/1380 - (27%)

  Fly     9 AKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIH-LNDLYT 72
            |...||....|:.      :.:..:..|:|..|.||:..|....::  ..|......| ||:||.
  Fly     3 ANLENGQKTIAST------SKSHSQRQTTSRRRQNDSDVAGGVGIT--GGGVVILPQHVLNELYH 59

  Fly    73 RYRQRLRKSLFRSGLLTSLLACVVSII--IGIVYGQ--------------HLVQTMLL------- 114
            .|..:.|    ||||...:.|..:..|  |||.:.|              :|..|.||
  Fly    60 NYSIKQR----RSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSD 120

  Fly   115 ---------VLAALISGS--ILTALQFPAVL-----SSPAAALAFAIVTTFSLGTIAAITGDELA 163
                     :|..::..:  :|:.|.|...:     .||...|.:||:..|    :..:|
  Fly   121 KPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNF----LVYVT----- 176

  Fly   164 PLPMYALFL-----CIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEI----V 219
             ||:..:||     ||...:.:|.||.                     |:....:|..::    |
  Fly   177 -LPLQLIFLGLSIGCITYFICLSLPVG---------------------YSHWDSLLSNQLAANAV 219

  Fly   220 MLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIM 284
            ::|:|::.||.|..|.:|...|.....:..:|.::.:|.:..:||:|||||:|.::|.:::..:
  Fly   220 LIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL- 283

  Fly   285 LKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRF 349
                         .|:|:..|.::::.||.||:||:||||.||.:||:.:|.||||.||:||.||
  Fly   284 -------------GSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARF 335

  Fly   350 DQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIH 414
            |::|::.|.||||||||||||:||.|..||.||..||:|||.|:.||::|::.....||||:|||
  Fly   336 DRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIH 400

  Fly   415 TGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAY 479
            ||.||.|:||.|:|||||:|.||.|||.|||.|.||||||:.:||.||..:||||...|..|:..
  Fly   401 TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL 465

  Fly   480 LADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTV 544
            |....:::|.|                             ||.:|                  ..
  Fly   466 LRIAGLKTYFI-----------------------------TKVVK------------------AF 483

  Fly   545 APPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKND 609
            |.|.|        ..||..:|.:..|..:.::..|  :|:|:|  ::||...|.|:.::.
  Fly   484 ASPCA--------KKINETQAEIAHPNPNGSTTDI--VSDEDD--NDATLDDEELLAQNS----- 531

  Fly   610 KEPKANGGHRGSGDSAASESVAKSAALSLP-ADDLLSMSGSESGISNSGAQAQSSNPASVTPTAA 673
               .:||...|...:|..|...|....... .|:|::..|.|:...::....:..||
  Fly   532 ---VSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNP-------- 585

  Fly   674 APAGGAASNSLTVAEAPERSRRKLS------VQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSH 732
                 .......|...|..|...|:      :..|.|:....||          ::|
  Fly   586 -----QLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRS----------TLH-------- 627

  Fly   733 AGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIE--SNLLPPERKCFNFNFF 795
                                     |.||| :.||....|..|::.|  |.:||        .||
  Fly   628 -------------------------FINIA-APLVPIAMLVVISLAESFSGMLP--------KFF 658

  Fly   796 GPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLAS 860
                                     .|...||:.| .||..|:..::.|.:...|:
  Fly   659 -------------------------VDVSKRFNDI-TFVRELAAIIIALTIGFSNV--------- 688

  Fly   861 FVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPD 925
               :.:|.:::.:        .||     .:|:.|.:         |:   :.::.|.||..|..
  Fly   689 ---IDMFFFVTFV--------RTE-----HIVSESEF---------NV---TASLESDINLVVEG 725

  Fly   926 GVSKE---PSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSG 987
            .|:.|   |:|            ||....:         |:|...| ||         .::|.:.
  Fly   726 MVTAEHLLPAS------------FVEQMRD---------AVPTERV-LY---------PSYLSNF 759

  Fly   988 FILKLIAMLVAVIAQVT-------------------VLGYSDLFEMYNDANITHGLPLEIKGFLL 1033
            .:|.|||  :|||||:|                   :....||:.:.:|......:........|
  Fly   760 GVLILIA--IAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGL 822

  Fly  1034 LLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFL-HLER 1097
            |||..|.|.||.|..::..|..|.||.::..::|....||..|:.|:.|:||.|||.||: :.:|
  Fly   823 LLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKR 887

  Fly  1098 S-TELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKI 1161
            | .:||.:||:.|.|:|||:||:.:||.|..||.|||||||.|||:|.|||.||..|:|..|.||
  Fly   888 SHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKI 952

  Fly  1162 KTIASTYMCASGLRPGKEDGATSRSFADEKRTEE-HNVVILVEFAIALMSILDSINRESFQRFRL 1225
            |||.||||.|||:...:    |.|:  |...||. .::.||||||:.|...|.|||.:||..|.|
  Fly   953 KTIGSTYMAASGINVQR----TVRN--DAPITERWSHLAILVEFALELKHALQSINEQSFNHFVL 1011

  Fly  1226 RIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGL 1290
            ::|:||||:.||||||:||.||||.|||||||||:|.|..|.:|.||.|..||...||....|||
  Fly  1012 KMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGL 1076

  Fly  1291 TYVKGKGNLVTYFVK 1305
            ..|||||.|:|::::
  Fly  1077 VAVKGKGQLMTFYLQ 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	62/269 (23%)
		CYCc	259..467	CDD:214485	108/207 (52%)
		Guanylate_cyc	311..469	CDD:278633	98/157 (62%)
		BASP1	510..667	CDD:283191	30/157 (19%)
		CYCc	1079..1283	CDD:214485	113/206 (55%)
		Guanylate_cyc	1101..1305	CDD:278633	114/204 (56%)
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	42/202 (21%)
		CYCc	256..453	CDD:214485	109/210 (52%)
		Guanylate_cyc	294..476	CDD:278633	104/181 (57%)
		CYCc	860..1071	CDD:214485	118/216 (55%)
		Guanylate_cyc	892..1092	CDD:278633	114/206 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D57794at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	P	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750